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Showing 1 to 3 of 3 for “"aeruginosins"”.
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Synthesis of Novel Chiral Heterocyclic Compounds for Antibacterial Agents and Peptidomimetics
… of heterocycle-containing molecules are the Aeruginosins. They are a family of marine natural products isolated from a blue-green algae, which display inhibitory activity against serine proteases such as thrombin, trypsin, and factor VIIa. Most aeruginosins contain an heterocyclic moiety …
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Synthesis and biological evaluation of aeruginosin based compounds and self-assembly of glucosamine based compounds
<p>Aeruginosins are a family of marine natural products containing mostly non-proteogenic amino acids. These compounds contain a common 2-carboxy-6-hydroxy-octaindole (Choi) rigid bicyclic structure. Many aeruginosins are inhibitors for enzymes involved in the blood coagulation cascade, such as …
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Synthesis of chiral intermediates by deritivization of monosaccharides
… of natural products and peptidomimetics. Aeruginosins contain novel bicyclic amino acid, 2--‐carboxy--‐6--‐hydroxyl octahydrindole (Choi) as the core structure. Aeruginosins are tetra peptide serine protease inhibitors isolated from marine sponges and cyanobacterial water blooms. Rigid …