Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"aerobic glycolysis"”.
-
The Role of Aerobic Glycolysis in the Resting Human Brain
… water, though some fraction of glucose undergoes aerobic glycolysis without concomitant oxidative phosphorylation. Elevation in neuronal activity increases aerobic glycolysis due to the disproportionate increase in blood flow and glucose utilization greater than oxygen consumption. Since aerobic …
-
Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
… gastric cancer to 5-FU might be related to the aerobic glycolysis pathway which depends on the hypoxia-inducible factor 1α (HIF 1α). I investigated HIF1α expression and responsiveness to 5-FU in two different types of gastric cancer cells (MKN45, SNU216). In addition, we …
-
Coordinated regulation of glycolysis and the folate one-carbon cycle
… and other proliferating cell types exhibit "aerobic glycolysis" characterized by elevated glucose uptake and conversion of glucose to lactate even in the presence of oxygen. Aerobic glycolysis is associated with anabolic reactions to generate new cellular material, but how aerobic glycolysis …
-
The Regulation of Glucose Metabolism during Osteoblast Differentiation
… lactate as the major end product even in aerobic conditions, a phenomenon known as aerobic glycolysis. However, the significance of increased aerobic glycolysis for bone formation was not known. Based on the link between metabolic abnormalities and the genetic mutations in WNT pathway …
-
Regulation of mitochondrial respiration by LDHB suppression in hepatoma cell lines
Increase in aerobic glycolysis and mitochondrial dysfunction are important metabolic features in human cancers. However, it still remains unclear how these phenomena are developed during tumorigenesis. To maintain aerobic glycolysis, continuous generation of NAD+ by lactate dehydrogenase (LDH) with …
-
DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
… from mitochondrial oxidative phosphorylation to aerobic glycolysis, a phenomenon described by Otto Warburg nearly a century ago. This seems to be necessary to meet bioenergetic and biosynthetic demands of rapidly dividing tumor cells. However, the mechanism underlying the switch from aerobic …
-
Bioenergetic Evaluation of Site-specific Keloid and FKN Fibroblasts
… significant metabolic switch towards aerobic glycolysis in the fibroblasts from the disease conditions. During functional measurement of mitochondrial parameters, an increase in oxidative phosphorylation was exhibited in the disease conditions indicating their mitochondria were still …
-
Regulation of Akt ignal transduction by glucose metabolism
Aerobic glycolysis is carried out at an inordinately high rate in cancer cells, a phenomenon known as the Warburg effect. While the relevance of this effect is unclear, it is partly driven by upregulation of the glycolytic enzyme 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3 (PFKFB3). …
-
Manometric Studies of Earle's Strain L Sarcoma Cells
… of 1) low oxygen uptake rates, 2) high aerobic glycolysis, and 3) high anaerobic glycolysis reported by Warburg have been found by later workers (5,6,7,8) to be descriptive of all malignant tumor tissue enabling a classification of what is or is not cancer tissue by metabolic …
-
Investigating the Role of Complex I Loss in Thyroid Tumorigenesis
… after observing that tumor cells often perform aerobic glycolysis in culture. Since then, multiple studies have demonstrated that most tumors actually require intact cellular respiration for proliferation. However, cancers of the colon, kidney, and thyroid are enriched in loss-of-function …
-
Fluxomic Evaluation of Bovine Embryo Nutrient Utilization
… demonstrated that the bovine embryo utilizes the aerobic glycolysis pathway for some energy generation. This pathway was shown to be used to a greater extent when glucose was the only simple sugar provided to the embryo compared to fructose.
-
Studies on mammalian pre-mRNA splicing : connections to transcription and cancer
… to lactate. This phenomenon is known as aerobic glycolysis, and is critical for cancer cell growth. The pyruvate kinase isoform expressed by the cell is a key determinant of glucose usage. Pyruvate kinase in most tissues is produced from the PKM gene, which is alternatively spliced to …
-
Regulation of Reparative Macrophage Transition by the B-cell Adapter for PI3K (BCAP)
… state. BCAP deficiency also results in defective aerobic glycolysis and reduced lactate production. This translates into reduced histone lactylation and decreased expression of reparative macrophage genes. Thus, our results reveal BCAP to be critical cell intrinsic switch that regulates transition …
-
The host response to cancer and cancer-associated cachexia
… neutrophils in tumour-bearing animals utilize aerobic glycolysis, similar to cancer cells. Although pharmacological inhibition of aerobic glycolysis slows down tumour growth in tumour-bearing mice, it precipitates cachexia. This negative effect may be explained by the observation that acute …
-
ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… of hyperactive de novo lipogenesis and aerobic glycolysis, two hallmarks of cancer cells. We demonstrated that LPA induced proteolytic activation of sterol regulatory element binding proteins (SREBPs) in a cancer specific manner, leading to activation of the SREBP-FAS (fatty acid …
-
Regulation of alternative splicing and its connections to cancer
… to lactate. This phenomenon is known as aerobic glycolysis, and is critical for cancer cell growth. The pyruvate kinase isoform expressed by the cell is a key determinant of glucose usage. Pyruvate kinase in most tissues is produced from the PKM gene, which is alternatively spliced to …
-
Toxoplasma gondii-mediated Host Cell Transcriptional Changes Lead to Metabolic Alterations Akin to the Warburg Effect
… feature of cancer metabolism – that of aerobic glycolysis (the Warburg effect) – in order to satisfy its own energetic and metabolic needs.
-
Bioenergetics and metabolism of eukaryotic cell proliferation
… growth of plant cells is associated with aerobic glycolysis in a mechanism that may be suppressed by light. Collectively, these studies contribute to a more holistic understanding of the bioenergetics and metabolic pathways employed by eukaryotic cells to accumulate biomass and lay the …
-
Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors
… acid independent of oxygen concentration ("aerobic glycolysis"). This altered phenotype is facilitated by expression of primarily fetal enzyme isoforms in these malignant tumors. The end-product lactic acid is rapidly expelled from the cytosol by selective monocarboxylate transporters …
-
Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… were evaluated. Cancer cells are dependent upon aerobic glycolysis (the Warburg effect) and glutamine uptake. Using clinically approved tyrosine kinase inhibitors and Bortezomib, significant enhancement of chemosensitivity was observed when used in combination with inhibitors of lactate …
Page 1 of 2