Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"adverse remodeling"”.
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Estrogen Modulation of Cardiac Immune Cells Is Cardioprotective.
… failure. A hallmark of heart failure is the remodeling of the hearts' structures, particularly the ventricles. In males with aortocaval (AV) fistula chronic volume overload model of heart failure, ventricular hypertrophy and dilatation are compensatory responses to this increase in volume. …
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UNVEILING NOVEL CARDIOPROTECTIVE EFFECTS OF GYY4137, A SLOW-RELEASING HYDROGEN SULFIDE DONOR, AND THEIR RELATIONSHIP TO NEUROHORMONAL MODULATION AND MICRORNA PROFILES DURING MYOCARDIAL ISCHEMIC INJURY.
… GYY preserves cardiac function, attenuates adverse remodeling and may exert post-ischemic cardioprotective (pro-angiogenic, anti-fibrotic) effects in part through enhanced early post-ischemic endogenous natriuretic peptide activation and possibly through microRNA modulation.
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. METHODS: Sprague-Dawley rats implanted with allograft infra renal abdominal aortic conduits were divided into 2 groups according to whether they were treated with G-CSF (+G-CSF group; n = 6) or without …
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Role of the Endocannabinoid System in Cardiac Remodeling
… receptors have been implicated in cardiac remodeling with CB1 inhibition and CB2 activation reported to be beneficial. However, the role of these receptors in cardiac remodeling secondary to hypertension is not known. Moreover, the functions of the CB1 and CB2 cannabinoid receptors in …
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Device-Enabled Biomechanical Modulation of the Infarcted Heart
… impedes cardiac function, prompts tissue remodeling, and ultimately can induce heart failure (HF)—a prominent cause of long-term morbidity and mortality. Current clinical practice focuses on preventing or managing HF in these patients through medication and lifestyle changes, and if HF is …
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Cardiomyocyte-Specific Deficiency of Ketone Body Metabolism Promotes Accelerated Pathological Remodeling
<p>During evolution of adverse ventricular remodeling that culminates in cardiomyopathy and congestive heart failure, myocardial fuel utilization becomes inefficient and inflexible, and mechanistic studies in pre-clinical models indicate that altered substrate and energy metabolism can cause …
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Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function
… was that deletion of A<sub>2B</sub>R reduces adverse remodeling in post-MI, and selective activation of A<sub>2B</sub>R increases WT murine CF collagen and pro-inflammatory cytokines production. </p> <p>In our in vivo studies, MI was induced by permanent coronary artery occlusion in male WT …
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Elucidating the role of LARP6 in cardiovascular remodeling
… treatments and therapeutics. Of note, structural remodeling of the heart precedes the onset of overt symptoms that diminish a patient's quality of life. Many factors contribute to the adverse remodeling and dysfunction observed in heart failure. Of note, obesity, excess sympathetic drive, elevated …
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The role of pulmonary arterial stiffness in right ventricular remodelling in COPD
… therapeutic target before end stage arterial remodeling occurs. Traditionally the assessment of the arterial stiffness required right heart catheterization, however recent advance in MRI are yielding new opportunities to undertake this assessment noninvasively. Pulse wave velocity is one of …