Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"adverse outcome pathway"”.
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Application of Adverse Outcome Pathway framework in assessing nanogold exposure to Daphnia magna
… (OECD) protocols for toxicity testing. The adverse outcome pathway (AOP) consists of a molecular initiating event (MIE), collective key events (KEs) that can be measured which lead to an adverse outcome (AO), that needs to have a regulatory consequence. The AOP framework will be utilized in …
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Airway Epithelium Organotypic Culture Models as a Platform for Adverse Outcome Pathway Assessment of Engineered Nanomaterials
… and targeted gene expression, canonical pathway enrichment, and upstream transcriptional regulation to understand GÃ P effects on transcriptional response to AgNP toxicity. We pursued a targeted analysis to characterize dose, genotype, and phenotype effects on expression patterns of genes …
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Towards an understanding of synthetic glucocorticoid hazards in aquatic systems.
… and define mechanisms associated with apical outcomes following exposure in aquatic matrices. First, I performed a critical review of existing literature to characterize the global occurrence of synthetic glucocorticoids in freshwater matrices detected by either analytical chemistry methods or …
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In Silico Classification of Industrial Chemicals Associated with Acute Aquatic Toxic Action Utilising Molecular Initiating Events
… Initiating Events (MIEs) of the relevant Adverse Outcome Pathway(s). Utilising the MIE allowed direct linkage between structural chemistry responsible for toxicity and the adverse outcome. Other considerations included information on the MIE target structure, i.e. the interaction, …
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Towards an understanding of the developmental zebrafish (Danio rerio) proteome and impacts of age-specific sensitivities with a model toxicant.
… for modern toxicology approaches to employ the adverse outcome pathway (AOP) framework and new approach methodologies to increase throughput, reduce cost, and link molecular interactions to organismal and population scale consequences through the use of omic tools and alternative models. …
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Investigation of in Silico Modelling to Predict the Human Health Effects of Cosmetics Ingredients
… approaches have been developed. Within the Adverse Outcome Pathway (AOP) paradigm, the molecular initiating event(s) MIE can be induced by several chemical key features which can be captured by structural alerts. When structural alerts for a MIE are compiled and supported by mechanistic and …
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Development of in silico models to support repeat dose safety assessment of cosmetic ingredients to humans
… and their ingredients, do not cause any adverse human health effects under normal usage; to ensure this, risk assessment must be performed. Traditionally, risk assessments are performed in vivo, i.e. conducting tests on animals using the chemical(s) of interest. However, over the past …
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Structure-based Predictions for Molecular Initiating Events
Toxicity testing of chemicals is currently undergoing its largest ever paradigm shift, moving towards faster, cheaper and more human-relevant methods which focus on mechanistic understanding. An AOP provides a framework for organising biological knowledge and data. The gateway to an AOP is the MIE, …
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Accurate Uncertainty Quantification and Explainable Artificial Intelligence in Machine Learning Models for Toxicological Risk Assessment
Consumer and environmental safety decisions can be supported by Quantitative Structure-Activity Relationship (QSAR) models – a key part of the Next Generation Risk Assessment strategy for animal-free safety. Machine learning methods are often employed to build QSAR models, but these “black box” …