Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"adverse drug effects"”.
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The role of mitochondrial transporters in human physiology and adverse drug effects
… the role of human mitochondrial transporters in adverse drug effects, to overcome the technical challenges in their functional characterisation and to identify compounds that can inhibit substrate transport. So far, most drug interactions have been reported for the mitochondrial ADP/ATP carrier …
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Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data
Adverse drug effects are unintended and undesirable effects of medicines, causing attrition of molecules in drug development and harm to patients. To anticipate potential adverse effects early, drug candidates are commonly screened for pharmacological activity against a panel of protein targets. …
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Drug prescribing and administration changes in hospitalized geriatric patients : analysis of three drug utilization review programs
… patients or 0.5% of the population. The use of drugs in this population comprises approximately 25% of the prescription drug market in the United States which is directly related to the greater occurrence of pathological problems associated with the aging process. While it is evident that the …
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The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… becomes critical to offset the vasoconstrictive effects of norephinephrine, angiotensin II, and vasopressin. Nonsteroidal anti-inflammatory drugs (NSAIDs) produce both their beneficial and detrimental effects through inhibition of the cyclooxygenase enzyme and subsequent interference with …
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Rates of Switching First-Line Antiretroviral Regimen Tenofovir-Emtricitabine-Efavirenz combination in a Primary Care Service in South Africa
… More evidence has emerged to show long term adverse effects of Efavirenz(EFV). This study assesses the adverse effect profile of TEE by determining the event rate of switching from co-formulation and the reason for such switch. Method: This retrospective cohort study involved the review of …
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Human Factors Contributing to Preventable Adverse Drug Events in Healthcare: A Grounded Theory Approach Pilot Study
… methodology (GT) pilot study of preventable adverse drug events (pADEs) in healthcare. This research used the methodological approach to develop a categorical theory for the chief workplace contributors to intra-hospital intensive care unit (ICU) preventable adverse drug events. While this …
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Adverse Effects of Asparaginase in Pediatric Patients with Acute Lymphoblastic Leukemia
… for ALL. However, its use is complicated by adverse effects, such as hypersensitivity, osteonecrosis and pancreatitis.</p> <p>Hypersensitivity to asparaginase typically requires discontinuation of current formulation and substitution with other formulations, but the differential diagnosis can …
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Multivariate analysis of metabonomic data
… of diseases and the evaluation of beneficial adverse drug effects, by studying the metabolic profiles of living organisms. This is achievable by studying samples of various types such as tissues and biofluids. The findings of a metabonomics study for a specific disease, disorder or drug …
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Evaluation of rationality and risks of pharmacotherapyin older patients in long-term care facilities
Záměr Hlavními cíli této disertační práce bylo zhodnotit dostupné informace týkající se farmakologických vlastností benzodiazepinů a jejich změn vlivem stárnutí organismu; zhodnotit prevalenci použití benzodiazepinů u geriatrických pacientů v léčebnách pro dlouhodobě nemocné; analyzovat vztah mezi …