Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"advanced disease"”.
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Engineered Heart Tissues for Advanced Disease Modeling
… (DMD), a severe, X-linked, neuromuscular disease, the mechanisms underlying the associated dilated cardiomyopathy (DCM) are not completely understood. This is due in part to the lack of suitable animal models of DMD-associated DCM which can accurately reproduce the disease’s progression in …
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The efficacy of intermittent directly observed isoniazid in preventing tuberculosis in HIV-infected adults with advanced disease
… there are insufficient data on patients with advanced HIV disease from high tuberculosis incidence areas. It is important to exclude tuberculosis prior to such preventive therapy, but this can be difficult in patients with symptomatic HIV disease. A tuberculosis screening instrument is thus …
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Understanding the dignity experience and exploring the impact of dignity therapy and guided imagery on patients with advanced disease - a South African perspective
… the dignity experience of patients with advanced disease from diverse socio-economic and cultural backgrounds in a South African context. In addition, the psychotherapeutic interventions, Dignity Therapy and Guided Imagery (focused on intrinsic dignity), were implemented to enhance the …
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Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models
… of cases and better treatments for patients with advanced disease are desperately needed. Understanding the molecular pathways involved in CaP initiation, progression, and resistance to treatment may help identify novel therapeutic targets. However, the molecular complexity of individual CaP …
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Outcome after breast cancer in Singapore and Malaysia
… Elderly Singaporean patients present with more advanced disease and are less likely to receive adequate treatment compared to younger Singaporean patients. Singaporean patients overall still have some way to go before they can achieve survival rates seen for the SEER (USA) patients which can …
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The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer
… four primary end points: tumour response rate, disease free survival, overall survival and health related quality of life. Health related quality of life (HRQoL) is a multidimensional concept, which encompasses a patient’s perceptions of both negative and positive aspects of the four main …
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Regulation of Survivin Gene Expression In The Human Endometrium and Endometrial Cancer
… lower in patients diagnosed with late stage, advanced disease and much higher for patients diagnosed in early stage disease (47). Endometrial cancer (EC) has been associated with several risk factors including obesity, diabetes, hypertension, previously documented occurrence of hereditary …
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Ultrahigh resolution optical coherence tomography for the detection of early stage neoplastic pathologies
… of changes associated with early stage disease remains a critical objective of clinical detection and treatment. Effective screening and detection is important for improving outcome because advanced disease, such as metastatic cancer, can be difficult to impossible to cure. Many existing …
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Clinical-pathological characterisation of children with B-cell non-Hodgkin lymphoma over a ten year period at a tertiary centre in Cape Town
… = 12) had concurrent active tuberculosis. Bulky disease was present in 65.7% (n = 46) and 30.1% (n = 22) were classified as Lymphomes Malins B (LMB) risk group C. The five year survival estimates for HIV-negative and HIV-positive children were similar in our cohort: 81% vs. 79% for eventfree …
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Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis
… worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor lesions and stages of disease progression have not been well characterized for most types of lung cancer. Furthermore, there …
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Aerobic exercise training as a mitigator of nonalcoholic fatty liver disease related fibrosis
… Nonalcoholic steatohepatitis (NASH) is a liver disease that is associated with obesity and is characterized by inflammation and fibrosis (scar tissue) within the liver. This condition is difficult to study in humans, therefore rodent models often are used to better understand factors that cause …
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Vitamin A status of HIV-infected adults in South Africa
… or plasma vitamin A levels in adults with HIV disease. Limited data suggests that HIV-infected adults from developing countries show even lower vitamin A levels. Factors that contribute to a low vitamin A status include a poor intake, malabsorption and repeated episodes of infections resulting …
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Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
… However, bladder cancer is a highly heterogenous disease and our understanding of the mechanisms that drive disease progression remain ill-defined. Additionally, a limited range of therapeutics and the dismal prognosis of patients with advanced disease highlights a need for better understanding of …
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Genetic Alterations in Advanced Head and Neck Cancer
… <br>All 36 patients assessed in this study had advanced disease and histologically confirmed complete resection of their tumors followed by standard radiotherapy of 60 Gy in 30 fractions. Cancer-specific survival and local-regional control were not significantly different for patients with or …
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A Qualitative exploration Of A Support Group Intervention Among Women With Cervical Cancer At Tiyanjane Clinic For Palliative Care, Queen Elizabeth Central Hospital, Blantyre, Malawi.
… of women with cervical cancer present with advanced disease where cure is not possible. These women face many challenges that affect their lives holistically. In particular, the psycho-social impact is common for women living with cervical cancer and psychosocial care does not have …
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Oncofetal Proteins Drive Aggressive Disease in Basal Pancreatic Cancer
… other organs, and the only treatment option for advanced disease is combination chemotherapy. Targeted small molecule inhibitors and immunotherapies have encountered rapid resistance and are not yet clinically approved. Identifying disease subtypes and targeting therapies to these subtypes …
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Cardiorespiratory abnormalities in early and advances stage mouse models of Duchenne muscular dystrophy
… dystrophy (DMD) is an X-linked severe muscle disease caused by dystrophin gene mutations affecting 1 in 3,500 newborn males worldwide every year. DMD is characterized by progressive skeletal muscle degeneration and weakness. In advanced disease, respiratory insufficiency and dilated …
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The dynamics of the serum concentration of CEA, CA15-3 and CA19-9 and survival in patients treated for advanced breast and colorectal cancer. The determination of the prognostic correlates of changes in tumour markers CEA, CA15-3 and CA19-9 during chemotherapy treatment for advanced breast and colorectal cancer.
… and CA19-9 provide valuable information about disease state over time in patients with advanced breast and colorectal cancer but the literature contains differences in methodology so comparing findings is difficult. By modifying criteria developed by Rustin and colleagues [1-5] in ovarian …
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Mitochondrial Uncouplers: Development as Therapeutics for Metabolic Diseases
… result in deteriorated health (cardiovascular disease, diabetes mellitus, hypertension, etc). A comorbidity of specific relevance is non-alcoholic fatty liver disease (NAFLD) and its advanced disease state known as non-alcoholic steatohepatitis (NASH), as it has had a documented rise in …
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Identification and Utility of Dna In Exosomes
… especially when patients initially present with advanced disease. Early detection methods have improved survival rates but remain unavailable for a majority of cancers due to a lack of sensitive biomarkers or numerous limitations associated with current diagnosis strategies. Approaches to develop …
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