Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 109 for “"adult brain"”.
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Identifying the role of microglia in mediating ASD-relevant phenotypes in the adult brain
… maintenance and survival of microglia, the brain’s resident immune cells, requires signalling via the colony stimulating factor 1 receptor (CSF1R). The Fms intronic regulatory element (FIRE), a highly conserved super enhancer found in the second intron of Csf1r, is also required for the …
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Regulation of survival and synaptic connectivity in the adult brain by cell-intrinsic excitability
… the olfactory bulb and dentate gyms of mammalian brains is by now an accepted fact, the function of adult-generated neurons still largely remains a mystery. The ability of new neurons to form synapses with preexisting neurons without disrupting circuit function is central to the hypothesized role …
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Profiling the dynamics of the active transcriptome in the juvenile and adult brain using spatial transcriptomics
The human brain is made up of a collection of distinct cell types that play specialized roles in maintaining proper brain function. The process of maturation of this complex organ can be assessed by examining the dynamics of gene expression within the various cell types. Previous studies have used …
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Impact on Endogenous Neural Stem Cells and Neurogenesis by Drugs of Abuse: From Fetal Neurodevelopment to the Adult Brain
… of cells, found within the fetal and adult brain, that are integral to brain development, maintenance, and repair. Neurogenesis is the process through which NSCs proliferate and differentiate to create new neural cells within the central nervous system. These cells are vulnerable to …
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The Brain Invaders: Widespread Neuronal Dispersion in Developing and Adult Mammalian Brain
… is the principal determinant of the final brain cytoarchitecture. However, we have only limited knowledge about the migratory pathways and mechanisms utilized during brain development. In my thesis I present new and unexpected findings about neuronal migration in the developing forebrain. I …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… are generated from progenitor cells. In the adult mammalian brain two sites of high density cell division have been identified that contain neural progenitor cells retaining the ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the subventricular zone (SVZ) …
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Applications of Hybrid Diffuse Optics for Clinical Management of Adults After Brain injury
… for clinical management of patients after severe brain injury. Unfortunately, current modalities for monitoring brain are often limited by hurdles that include high cost, low throughput, exposure to ionizing radiation, probe invasiveness, and increased risk to critically ill patients when …
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Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling
Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well …
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Epidemiological and pathological correlates of early neonatal mortality
… understanding and identification of antenatal brain injury is poor and individual vulnerability may be important. Specific genotypes such as Apolipoprotein E are disadvantageous to outcome in the context of adult brain injury and may also be important in early development.
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
Neurogenesis in the adult mouse brain occurs within the subventricular zone (SVZ) of the lateral ventricle. In the SVZ, neural stem cells (NSC) reside in a specialized microenvironment, or vascular niche, consisting of blood vessels and their basement membranes. Most NSCs in the SVZ differentiate …
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Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo
… only during development, but is prevalent in the adult brain and likely represents the physical correlate of learning and memory. Removal or addition of excitatory and inhibitory synaptic inputs onto a neuron can affect their relative influence on excitation in specific dendritic segments, and …
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Effects of Transcranial Direct-Current Stimulation on Motor Learning in the Developing Brain
… stimulation (tDCS) is a form of non-invasive brain stimulation applied in both healthy and clinical populations. Application of weak current induces electric fields at the neuronal level, and may lead to behavioral effects such as enhanced motor learning when paired with training. Nearly all …
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RNA helicase MOV10 is essential for gastrulation and normal CNS development
… helicase Moloney Leukemia Virus 10 (Mov10) in brain and modulates its translational activity through the microRNA (miRNA) pathway. FMRP is critical for normal cognition and our findings hypothesize a role for Mov10 in brain function. Additionally, Mov10 has a well- documented role of protecting …
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Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
Neurogenesis in the adult brain is a complex and lifelong process that is regulated by multiple pathways and is sensitive to many external stimuli. Two critical regulatory factors in this process are NRSF/REST and NeuroD1. NRSF/REST, a transcriptional repressor that binds a specific NRSE site and …
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The Role of Cdk5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior
… and spatial control of Cdk5 expression in the adult brain. Loss of Cdk5 in the adult brain increased the psychomotor-activating properties of cocaine and enhanced incentive motivation for food. Behavioral changes were accompanied by increased excitability of medium spiny neurons in the nucleus …
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Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
The discovery of adult neural stem cells (NSCs) has revealed the potential of endogenous neurogenesis as a therapeutic mechanism for brain repair. Among the neurogenic niches of the adult brain, the subventricular zone (SVZ) responds to cortical injury by generating neuroblasts that attempt to …
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Function and evolution of the atypical Notch ligands Dlk1 and Dlk2 during vertebrate development
… and dlk2 during embryonic development and in the adult brain, determining similarities and differences between mouse and zebrafish. In particular, dlk1 and dlk2 in the fish exhibit a pattern that is more reminiscent of Dlk2 in the mouse. This developmental expression pattern is essential for the …
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Oligodendrocytes of the adult median eminence
… have shown that new OLs are generated in the adult brain from oligodendrocyte progenitor cells (OPCs) in response to physiologically relevant stimuli such as motor skill learning. Emerging evidence suggests that OL genesis is influenced by nutritional stimuli in the healthy and diseased brain, …
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Identification of Novel Genes Involved in Female Mating Choice
… and CG7423- are actually expressed in female adult brain.
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Primitive Neural Stem Cells in the Mouse Brain
… the tissue lining the lateral ventricles of the adult mouse brain. At the top of the hierarchy are primitive (p)NSCs that arise in advance of definitive (d)NSCs embryonically. After the discovery that pNSCs persist in the adult mouse brain, I sought out to characterize pNSCs and determine whether …
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