Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"adrenoceptor"”.
-
Characterisation of novel alpha1-adrenoceptor ligands
α1A-adrenoceptor (AR) antagonists used clinically to treat urogenital conditions, such as benign prostatic hyperplasia, have side effects due to a lack of subtype selectivity and the 5-HT1A-R off-target affinity. In this study, computer-aided drug design, structure-activity relationship, and …
-
Effects of beta-2 adrenoceptor agonists on the diaphragm
Contains fulltext : 146605.pdf (Publisher’s version ) (Open Access)
-
Beta-adrenoceptor blockade and stimulation in obstructive lung disease
Contains fulltext : mmubn000001_029174244.pdf (Publisher’s version ) (Open Access)
-
Soft [beta]-adrenoceptor agonists for topical use in psoriasis
… levels. This thesis describes a series of β-adrenoceptor agonists for topical delivery based upon the soft-drug approach. Soft drugs are defined as biologically active, therapeutically useful chemical compounds (drugs) characterised by a predictable and controllable In vivo destruction …
-
Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
β2AR (β2 adrenoceptor) is a prototypical G-protein coupled receptor (GPCR) that plays an important role in cardiovascular and pulmonary physiology through activation of the classic Gs-adenylate cyclase-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway. In the mammalian …
-
Arrhythmogenic potential of alpha-adrenoceptor stimulation in the rat heart
A recent proposal is that the alpha₁-adrenoceptor may mediate the arrhythmogenic effect of catecholamines during acute myocardial ischaernia. The purpose of this thesis was to explore the role of alpha₁ and alpha₂-adrenoceptor stimulation on vulnerability to ventricular fibrillation in the …
-
The electrophysiological and molecular effects of chronic beta-adrenoceptor antagonist therapy on human atrium
The chronic treatment of patients with a β-adrenoceptor antagonist is associated with prolongation of the atrial cell action potential duration (APD), potentially contributing to the ability of these drugs to prevent atrial fibrillation (AF). The mechanisms underlying this APD prolongation are not …
-
Cryo-EM studies of class A GPCRs: the thyroid-stimulating hormone receptor and the β1-adrenoceptor
… hormone receptor (TSHR) and the β1-adrenoceptor (β1AR) were studied. The TSHR is a class A GPCR that belongs to the family of glycoprotein hormone receptors. It carries a large extracellular domain (ECD) that binds to the endogenous ligand, the thyroid stimulating hormone (TSH). In …
-
The Effect of Phosphodiesterase Inhibitors on the Induction of Gene Expression by Long-Acting beta2-Adrenoceptor Agonists and Glucocorticoids
Recently, phosphodiesterases (PDE)4 inhibitors have received approval as a complementary anti-inflammatory treatment for chronic obstructive pulmonary disease (COPD) patients who are already taking long-acting β2-agonists (LABA)/inhaled corticosteroid (ICS) combination therapy. However, this …
-
Fusion Proteins as Selective Inducers of Constitutive Activity and Tools to Discriminate the Biased Signaling Profile of β2 Adrenoceptor Ligands
The β2AR is the prototypical G protein coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best-established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway. …
-
Regulation of cAMP-Dependent Gene Expression in Airway Epithelial Cells: A Transcriptional and Pharmacodynamic Analysis
… by suppressing inflammation. Long-acting β2-adrenoceptor agonists (LABAs) are effective bronchodilators that work by elevating cAMP in airway smooth muscle (ASM). Less appreciated and understood is the ability of cAMP to regulate gene expression. For example, previous studies have shown LABAs …
-
Adrenergic regulation of splenic functions in neonatal pigs
… the splenic nerve. Pretreating the NP with beta-adrenoceptor blocker, propranolol (1 mg/kg), had no significant effect on these responses. In contrast, these responses were abolished with the addition of alpha-adrenoceptor blocker, phentolamine (1 mg/kg). Splenic O₂ metabolism did not change …
-
Regulation of signal transduction by RGS4
… cells following co-expression of Gi1, the 2A-adrenoceptor, or agonist activated 2A-adrenoceptor. This translocation of RGS4 to the plasma membrane was most pronounced with the co-expression of the constitutively active GTPase deficient Gi1 Q204L. High-affinity GTPase experiments indicated that …
-
Dual Mechanism Analgesia-Enhancing Agents
… have shown that both 5-HT3 receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- adrenoceptor ligand. MD-354, …
-
The linking of angiogenesis to contractile performance and substrate metabolism in the hypertrophied and failing heart
… capillarity (e.g. hypertension and beta-adrenoceptor stimulation). In contrast to previous reports, capillary growth within the ventricle was very limited in animals exposed to a chronic increase in energy demand (e.g. cold environments) and those subjected to extended periods of …
-
The mechanisms involved in the responses elicited by intracerebroventricular administration of renin and angiotensin in the conscious cat
… drugs. The evidence indicated that central β-adrenoceptor or dopamine receptor mechanisms were involved. Drinking behaviour in the cat was also elicited by administration of hypertonic saline, polyethylene glycol or β -adrenoceptor agonists. A preliminary study of the contribution of renin and …
-
Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias
… and substrate deprivation. 3 . To explore beta-adrenoceptor mediated ventricular automaticity. 4 . To evaluate possible new anti-arrhythmic drugs, carminomycin and ketanserin.
-
In vivo and in vitro aspects of imidazoline-2(1/2)sites within the central nervous system
… the sympathomimetic d-amphetamine, the α1-adrenoceptor agonist methoxamine, but not the β1 agonist dobutamine or the β2 agonist salbutamol, gave rise to significant levels of substitution for the 2-BFI cue. The administration of the α1-adrenoceptor antagonist WB4101, prior to 2- BFI itself …
Page 1 of 3