Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"adrenergic receptors"”.
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Hypothalamic alpha adrenergic receptors and the regulation of LHRH release
… is primarily under the control of the $\alpha$ adrenergic system. The $\alpha$ adrenergic receptor subtype mediating LHRH release has not been established however. Also, most investigators have used changes in plasma luteinizing hormone to infer changes in hypothalamic LHRH release, rather than …
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A Study of the Adrenergic Receptors in Mammalian Tracheal Smooth Muscle
Adrenergic receptors of mammalian tracheal smooth muscle have been characterized. After beta-adrenergic blockade with propranolol, the responses to epinephrine in both human and guinea-pig tracheal smooth muscle were contractile. These dose-dependent contractions were blocked with the …
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THE IMPORTANCE OF SEROTONERGIC AND ADRENERGIC RECEPTORS FOR THE INDUCTION AND EXPRESSION OF ONE-TRIAL COCAINE-INDUCED BEHAVIORAL SENSITIZATION
… the induction process. For example, the α1b-adrenergic and 5-HT<sub>2A </sub>receptor systems are known to modulate the sensitized responding of adult rats, but the roles that these receptor systems play in the induction and expression of behavioral sensitization during the preweanling period …
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
… vasodilation through stimulation of CGRP 2 receptors. NE contracted BIAA rings with low potency (EC50 =11+2.0 pM), which was not due to metabolism of NE or stimulation of 0.2- or [3-adrenergic receptors (ARs). The cp-AR selective antagonist BE 2254 antagonized NE-induced contraction with …
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AUTORADIOGRAPHIC STUDIES OF THE REGULATION OF THE SUBTYPES OF THE ß ADRENERGIC RECEPTOR
The regulation of the subtypes of the ß adrenergic receptor following a number of treatment regimens was examined. Following a generalized catecholaminergic intraventricular innervation administration to of the lesion rat of CNS the by the compound 6-hydroxydopamine (6-0HDA) to adult rats, both …
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The role of beta3-adrenergic receptors in control of brown and white adipose tissues and of energy balance: Reversal of obesity by CL 316,243, a new beta3-adrenergic agonist.
… treatment of obesity with drugs is the $\beta$3-adrenergic receptor in brown and white adipose tissues. Selective $\beta$3-adrenergic receptor agonists have been developed that will stimulate both the mobilization of fat from white adipose tissue, the site of triacylglycerol storage in the body, …
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Comparison of Receptor Efficacies on Vascular Smooth Muscle Contraction
… the effects of phenylephrine (alpha<sub>1</sub>-adrenergic agonist, angiotensin II (AT<sub>1 </sub>agonist), clonidine (alpha<sub>2</sub>-adrenergic agonist) and moxondine (alpha<sub>2</sub>- adrenergic /I<sub>1</sub>-imidazoline agonist) on contraction in the rat-tail artery. Functionally, all …
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INFLUENCE OF BIOGENIC AMINES ON BOVINE LUTEAL STEROIDOGENESIS
… by both $\beta\sb{1}$- and $\beta\sb{2}$- adrenergic receptors. The alternative pathway catecholamines octopamine, synephrine and deoxyepinephrine enhanced basal progesterone production, and this response was mediated by $\beta$-adrenergic receptors. Analysis of luteal tissue using high …
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The novel role of epidermal growth factor (EGF) in the regulation of ion channels in the calu-3 submucosal cell line
… back to untreated levels. Stimulation of the β2 adrenergic receptors with salbutamol were not reduced using metalloproteinase inhibitor, GM-6001 and EGFR inhibitor, AG1478. This suggested that stimulation of β2 adrenergic receptors does not lead to transactivation of EGFR via activation of …
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Modulation of mitogenic signaling and growth by sympathetic adrenergic regulation
… of heart disease and diabetes are the adrenergic receptors (ARs) and insulin receptors (IR), respectively. Classically considered to elicit separate, and even opposing, cellular processes, increasing evidence suggests that ARs are capable of signaling cross-talk with other G-protein …
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ΣΥΓΚΡΙΤΙΚΗ ΟΝΤΟΓΕΝΕΤΙΚΗ ΚΑΙ ΤΟΠΟΓΡΑΦΙΚΗ ΜΕΛΕΤΗ ΤΩΝ Α1, Α2 ΚΑΙ Β ΑΔΡΕΝΕΡΓΙΚΩΝ ΥΠΟΔΟΧΕΩΝ ΣΤΙΣ ΠΕΡΙΟΧΕΣ ΤΟΥ Κ.Ν.Σ. ΚΑΙ ΣΤΗΝ ΚΑΡΔΙΑ ΠΤΗΝΟΥ (GALLUS DOMESTICUS)
… ONTOGENY AND LOCALIZATION OF A1, A2- AND B-ADRENERGIC RECEPTORS,RESPECTIVELY, IN CHICK BRAIN AND HEART. KINETIC STUDIES PERFORMED AT DIFFERENTEMBRYONIC AND POST- HATCHING AGES HAVE SHOWN ONE HIGH AFFINITY BINDING COMPONENT FOR 3H-CLONIDINE AND 3H-DHA AND A HIGH AND LOW AFFINITY STATE FOR 3H …
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Investigating intrathecal adeno-associated virus vectors for the study of analgesic interactions at the spinal level
… the most basic level. Several G protein-coupled receptors, including opioid and adrenergic receptors, are known to be potent regulators of pain signaling at the spinal level. Co-activation of different subtypes of these receptors can lead to synergistic inhibition of pain signaling. Understanding …
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Stress hormones epinephrine and corticosterone modulate herpes simplex virus 1 and 2 productive infection and reactivation primarily in sympathetic, not sensory, neurons
… cervical ganglia (SCG) neurons expressed adrenergic receptors and glucocorticoid receptor. In productively infected neuronal cultures, epinephrine treatment significantly increased HSV-1 DNA replication and production of viral progeny in SCG neurons, but no significant differences were …
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Site and Mechanism of Leptin's Antisteatotic and Insulin Sensitizing Actions in Lipodystrophic Liver
… Using mice with a knockout of all three p-adrenergic receptors, we showed that sympathetic nervous system, specifically p-adrenergic receptors are in part responsible for mediating leptin's peripheral effects. Using microarray analysis in livers of lipodystrophic animals treated with either …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… properties to primary cardiomyocytes. Adenosine receptors are well known mediators of cardioprotection and trigger effectors such as the mitochondrial KATP channel – however, the role of the mitochondrial BKCa channel in adenosine receptor-mediated cardioprotection has not been investigated. GPCR …
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Novel Characteristics of Murine Bone Marrow-Derived Macrophages and Human Macrophage-Like Cells
… and fusaric acid) or the β2 adrenergic receptor antagonist ICI 118,551 demonstrated that BMM produce catecholamines. The catecholamines modulated macrophage cytokine production through autocrine actions on adrenergic receptors. In study II, undifferentiated human bone marrow …
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Reciprocal Relationships Between the Neuroendocrine System and Lymphoid Cells
… and cathecholamines. Lymphoid cells possess receptors for both of these stress-related hormones, and activation of these receptors affects functional activities of lymphoid cells. In the present experiments, it is demonstrated that activation of porcine splenocytes with concanavalin A results …
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Effect of Long-Term Hypoxia on Myocardial Alpha1- Receptors
… changes in myocardial α<sub>1</sub>-adrenergic receptor system, we employed [<sup>3</sup>H-Prazosin] binding technique to characterize α<sub>1</sub>-adrenergic receptors in both fetal and adult sheep myocardial ventricular membrane preparations. Myocardial α<sub>1</sub>-adrenergic …
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Autocrine Effects of Catecholamines on Macrophage Release of Interleukin-6 (IL-6)
… complex because the cells have both α2 and β2 adrenergic receptors, which mediate opposing actions. Furthermore, β2-adrenergic agonists are reported to have both stimulatory and inhibitory effects on interleukin-6 (IL-6). This study was designed to clarify the autocrine role of …
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