Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 102 for “"adrenergic receptor"”.
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AKAP12 Signalosome Regulates Cardiac β2-Adrenergic Receptor Signaling
… downregulation, and recycling of β Adrenergic Receptors (βAR). Several AKAPs have been associated with cardiac function. AKAPs cardiac expression levels and intracellular distribution are altered under pathological conditions; however, AKAP12 cardiac roles are unclear. In this study, …
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Characterization of α₂-adrenergic receptor localization and functional responses
The three α₂-adrenergic receptors (α₂-ARs) were studied in both recombinant and endogenous systems. It was my general hypothesis that the three α₂-adrenergic receptor (AR) subtypes exhibit differential tissue and subcellular localization and couple to physiological pathways to directly elicit …
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Investigating the molecular signatures of β1-adrenergic receptor activation
… I have investigated the molecular signatures of receptor activation, using the β1-adrenergic receptor (β1AR) as a prototypical class A G-protein coupled receptor (GPCR). I have used a minimally thermostabilised turkey β1AR and expressed it functionally in insect cells using a baculovirus system. …
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Sex differences in the cardiac beta-adrenergic receptor contractile response
… is not present following menopause. &beta-adrenergic receptors are pharmaceutical targets in the treatment of cardiovascular disease, and sex differences in &beta-adrenergic responsiveness have been demonstrated. However, limited studies have addressed the mechanism(s) underlying these …
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Investigating the role of ICL3 in β1-adrenergic receptor activation
G protein-coupled receptors (GPCRs) are 7-transmembrane (7-TM) alpha helical membrane proteins involved in a myriad of physiological functions and have implications in many diseases. GPCRs are important targets for ~35% of commercial drugs. Activation of GPCRs by external signals and through …
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… sympathetic nerve endings. The nerve termini are adrenergic and secrete norepinephrine upon stimulation, which can modulate immune cell function primarily through the beta2-adrenergic receptor (ADRB2). Our previous work has demonstrated that various subsets of CD8+ T cells have differential …
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Role Of The α1A-Adrenergic Receptor In Synaptic Plasticity, Cognition & Neurogenesis
… involved in learning and memory. NE activates adrenergic receptors (ARs) and stimulating the α1A-AR subtype has been known to increase adult neurogenesis (ANG). We hypothesized that α1A-AR-induced ANG would enhance learning and memory. Constitutively active mutant (CAM) α1A-AR, α1A-AR knock-out …
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AUTORADIOGRAPHIC STUDIES OF THE REGULATION OF THE SUBTYPES OF THE ß ADRENERGIC RECEPTOR
The regulation of the subtypes of the ß adrenergic receptor following a number of treatment regimens was examined. Following a generalized catecholaminergic intraventricular innervation administration to of the lesion rat of CNS the by the compound 6-hydroxydopamine (6-0HDA) to adult rats, both …
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Investigation of the beta 2 adrenergic receptor (B2-AR) pathway in canine hemangiosarcoma
… vascular endothelial cells. Propranolol blocks adrenergic receptors, which would otherwise bind to catecholamines responsible for the “stress signal” leading to many physiologic changes. Stress has been implicated in many models of carcinogenesis and tumor progression. Given the relationship …
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Characterising the conformational dynamics of β₁-adrenergic receptor activation and G protein coupling
The G protein-coupled receptor (GPCR) family of seven-transmembrane signalling proteins facilitates cellular responses to environmental stimuli. GPCRs are integral to numerous physiological signalling pathways and thus many therapeutics have been developed to modulate receptor activity. Stimulation …
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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist in the Treatment of Diabetic Retinopathy
… have previously shown that a non-specific beta-adrenergic receptor agonist, isoproterenol, was effective in preventing functional and morphological changes associated with diabetic retinopathy in the rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the systemic …
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The Functional Characterization of QSEC a Bacterial Adrenergic Receptor and the LuxR Homologue SDIA in EHEC
… sensor kinase QseC is an inner membrane adrenergic receptor which responds to the bacterial signal autoinducer-3 (AI-3) and the host signals epinephrine and norepinephrine. EHEC senses these signals in the gut in order to coordinate expression of multiple virulence factors. These factors …
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Adrenergic Receptor Gene Expression in Bovine Leukocytes and Effects of Adrenergic Agonists on Neutrophil and Eosinophil Function
… (E) and norepinephrine (NE). The α- and β-adrenergic receptors (ARs) are encoded by 6 α- and 3 β-AR genes and these ARs mediate interactions between the stress hormones E and NE and immune cells. However, AR gene expression and function have been studied to a limited extent in bovine immune …
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Calcium Remodeling through Different Signaling Pathways in Heart Failure: Arrhythmogenesis Studies of Pyk2, Dystrophin, and β-adrenergic Receptor Signaling
… signaling, cytoskeletal signaling and β adrenergic receptor signaling pathway.</p><p>Proline-rich tyrosine kinase 2: Pyk2) is a non-receptor protein kinase regulated by intracellular Ca. It mediates a typical stress activated signaling pathways along with c-Src, P38 MAPK and regulates a …
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Myocardial Contractility in Fetal Sheep Exposed to Long-term Hypoxia at High Altitude : Activator Calcium and Beta-adrenergic Receptor Function
… dihydropyridine (DHPR), ryanodine (RyR), and β-adrenergic receptor densities, and measured basal and stimulated intracellular cAMP levels. In hypoxic fetuses, left ventricular wet weight was unchanged, but right ventricular weight was ~20% lower than controls. Curves describing the …
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Characterization of the Beta-2 Adrenergic Receptor Mechanism in Bovine Neutrophils, and Some Effects of Inflammatory Stimuli on its Function
… system. In particular, activation of the beta2-adrenergic receptor on these cells decreases several aspects of inflammatory activity, including reactive oxygen species production, chemotaxis, degranulation, and inflammatory mediator production. Dysfunction of beta-adrenergic receptors is known …
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Intimations on the Development of Effective Treatment for the Prevention of Preterm Birth: β3 Adrenergic Receptor Signaling in the Human Myometrium
… ineffective and none are FDA approved. The β3 adrenergic receptor (β3AR) has been shown to be present in various tissues, including the human myometrium. Using contractile studies, stimulation of the β3AR has been shown to mediate relaxation. Although some pathways have been described, the …
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