Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"adrenal medulla"”.
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Identifying the mechanism critical for proliferation, apoptosis, and cell-cell interaction in the development of mouse adrenals and gonads
Adrenal, testis, and ovary are steroidogenic organs derived from a common primordium that consists of Steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs, but also controls their differentiation. In this thesis project, I used …
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Normal cell signals in human cancer transcriptomes
… a single-cell normal reference of the fetal adrenal gland, and explore the development of the fetal adrenal medulla, from which the childhood cancer, neuroblastoma, arises. I then compare that reference to neuroblastoma single-cell and bulk transcriptomes in chapter 3. This comparison reveals …
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Mechanisms of neuronal integration in adrenomedullary sympathetic preganglionic neurons.
Sympathetic preganglionic neurons innervating the adrenal medulla (AD-SPN) regulate the release of adrenal catecholamines into the bloodstream. This research was undertaken to investigate the intrinsic properties and synaptic pathways characteristic of AD-SPN in neonatal rat spinal cord slice …
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COMBINATORIAL DEVELOPMENT OF NANOSTRUCTURED MATERIAL LIBRARIES FOR THE STUDY OF CELL SUBSTRATE INTERACTION
… cells derived from a Pheochromocytoma of the rat adrenal medulla were cultured on five different morphologies in presence of nerve growth factor (NGF) and the results suggest that the increasing roughness not only diminishes cellular attachment but also reduces the probability of differentiation …
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An in vitro cell lineage model to identify alterations in the differentiation program of neuroblastoma
… migrating cells that differentiate into sympathoadrenal precursors (SAPs) and Schwann cell precursors (SCPs). The SAPs are the direct progenitors of sympathetic ganglia neurons (SGNs), and of chromaffin cells (ChCs), the major cell population of the adrenal medulla (AM). The SCPs are known to be …
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Modulation of the sensitivity of nociceptive neurones by cannabinoids and SNSR
… see if the application of their agonist, bovine adrenal medulla peptide (BAM (8-22)), modulated the response of nociceptors in vitro. A sub-population of neurones was seen to sensitise in their response to capsaicin after exposure to BAM (8-22). A selection of kinase inhibitors was then employed …
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Effects of MPTP, MPP(+) and Adreno-Medullin on Dopamine Metabolism in the Rat Corpus Striatum
… model of Parkinson's disease induced by MPTP, adrenal medulla fragments were inserted directly into the striatum of the MPTP-lesioned animals. Therefore, it was of interest to examine the effects of MPTP and MPP$\sp+$ and of adrenal extract on dopamine metabolism in the corpus striatum. This …
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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers
… differentiate to form the sympathetic ganglia, adrenal medulla and other paraspinal sites where sympathetic nervous system tissue is present. Even with an extensive treatment regimen that typically includes surgery, chemotherapy, total body irradiation and autologous stem cell transplantation, …
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The development and evolution of vertebrate oxygen-sensing cells
… unknown. The chromaffin cells of the mammalian adrenal medulla are hypoxia-sensitive transiently during neonatal life. Both carotid body glomus cells and adrenal chromaffin cells arise from the neural crest and require the transcription factors Phox2b and Ascl1 for their development. Given these …