Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"adrenal insufficiency"”.
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Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency
Context: Individuals with primary adrenal insufficiency (PAI) or congenital adrenal hyperplasia (CAH) receive life-long glucocorticoid (GC) replacement therapy. GC doses used for replacement therapy in these diseases are much lower than GC doses used for immunosuppressive therapy. However, current …
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Die funktionelle Nebennierenrindeninsuffizienz nach schwerem Verbrennungstrauma : Physiologie und therapeutische Optionen
… study investigated the hypothalamus-pituitary-adrenal(hpa)-axis of 20 patients with severe burn trauma. A CRH-test was performed on day one after hospitalisation. The study hypothesized that functional adrenal insufficiency is common in this certain entity of a systemic inflammatory response …
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The Role of Dax-1 in Regulating Pluripotency in mouse Embryonic Stem Cells
… early embryonic development and, when mutated, adrenal insufficiency and disruption of normal tissue architecture results. In our study, we silenced Dax-1 expression in mouse ES cells using RNAi followed by PCR array methodology to identify genes that were alternately regulated upon targeted …
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Glucocorticoid Receptor Density and Binding Affinity in Horses with Systemic Inflammatory Response Syndrome
… to glucocorticoids, and potentially relative adrenal insufficiency as well. These results suggest that there are horses with SIRS that might benefit from "physiologic" doses of synthetic glucocorticoids to complement their relative adrenal insufficiency in addition to their poor tissue …
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Hypoglycemia In Mitochondrial Disorders
… criteria included diagnosis of diabetes or adrenal insufficiency or past or present use of hydrocortisone or prednisone. Patient charts were reviewed retrospectively for blood glucose values. Individuals with at least two values were recorded. Patients were classified as neonatal (≤28 days …
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Transcriptional Regulation by DAX-1 in Pluripotent and Differentiated Cells
… known to play a role in sexual development and adrenal insufficiency, expression in certain types of cancer suggests additional functions and interactions. Knock in of DAX-1 into a low-DAX-1 expressing cancer cell line has been previously observed to increase apoptosis, while, inversely, down in …
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IL SURRENE NELLA CIRROSI EPATICA: LA SINDROME EPATO-SURRENALICA
L'Insufficienza surrenalica (IS), definita da deficit di sintesi o di azione dei glucocorticoidi, dovuto ad un danno strutturale del surrene (IS primitiva) oppure ad un alterazione dell'asse ipotalamo-ipofisario (IS secondaria), è stata riscontrata con frequenza sempre maggiore in pazienti con …
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Uncovering molecular mechanisms of the notch signaling pathway in the regulation of pituitary gland development
… health conditions including growth deficiencies, adrenal insufficiency, infertility, and hypothyroidism. To understand the etiology of pituitary disorders we must elucidate the factors and molecular pathways that regulate pituitary cell fate choice and lineage specification. Previous studies from …
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Cortisol perturbation in the pathophysiology of septicaemia, complicated pregnancy and weight loss/obesity.
… the principal glucocorticoid secreted from the adrenal glands, is essential for life. Healthy cortisol levels are maintained through negative feedback on the central nervous system (CNS) – pituitary stimulatory apparatus which regulates production of adrenocorticotropin (ACTH) and contains a …