Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"adrb2"”.
-
Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
… I demonstrate a novel role for the beta2-ADR (ADRB2) in controlling inflammation. NE suppresses pro-inflammatory cytokine secretion from primary macrophages in response to multiple TLR agonists, and ADRB2 signaling enhances early induction of IL-10. In addition to its in vitro affects, I have …
-
Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… primarily through the beta2-adrenergic receptor (ADRB2). Our previous work has demonstrated that various subsets of CD8+ T cells have differential expression of the ADRB2 transcript. The role of ADRB2 signaling on the differentiation and acute effector functions of CD8+ T cells remains poorly …
-
Zusammenhang zwischen Therapieergebnis und genetischen Polymorphismen in der Behandlung adipöser Kinder
… in Genen des beta-adrenergen Systems (ADRB2, ADRB3, BUP),untersucht. Die untersuchten Polymorphismen im ACE, AT1R, ADRB3 und BUP-Gen zeigten keinerlei Zusammenhang zu den Therapieergebnissen. Die Veränderung der körperlichen Leistungsfähigkeit zeigte einen signifikanten Zusammenhang zu …
-
Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… cancer progression and its regulation by ADRB2 signaling remain unknown.</p> <p>Our <strong>hypothesis</strong> is that GRK3 and HDAC2 are critical downstream effectors of β-adrenergic signaling-activated CREB in promoting prostate cancer progression. Here, we show that CREB directly …
-
Genetic dissection of essential hypertension and familial intracranial aneurysm
… QTL including the b2-adrenergic receptor gene, ADRB2, which is known to have a major role in cardiovascular physiology. Three functional loci, Arg16Gly, Gln27Glu and Thr164Ile, were genotyped within the ADRB2 gene using the Silesian sample. Single locus and haplotype analyses using transmission …
-
Genetic determinants of cognitive heterogeneity in Parkinson’s disease
… polymorphisms within beta-2-adrenegic receptor (ADRB2), Arg16Gly and Gln27Glu, to Mini-Mental State Examination performance over a 4-year period (N = 115). For the first time, I report an association between ADRB2 Glu27Glu genotype and cognitive impairment in PD, with affected individuals …
-
AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
… of ENaC channel, ATP12A proton pump, ADRB2 β-adrenergic receptor, and SLC26A4 anion exchanger. The overall result of IL-17A/TNF-α treatment was hyperviscosity of the airway surface, as demonstrated by fluorescence recovery after photobleaching (FRAP) experiments. Importantly, …
-
The effect of genetic variation on asthma severity and treatment in childhood
… Arg16 allele on the ß2 adrenergic receptor gene (ADRB2), on frequent doses of on demand short-acting ß2-agonists are at greater risk of asthma exacerbations.I have shown an increase in the risk of exacerbations per copy of Arg16 allele in children and young adults with asthma on the regular …
-
A Proof-of-Concept Study to evaluate the benefit from add-on therapy with montelukast versus salmeterol in children with asthma carrying the Arg/Arg-16 β2-receptor genotype
… may be affected by β2 adrenoreceptor genotype (ADRB2). The arginine-16 (Arg 16) variant of this gene predisposes to exacerbations in asthmatic children and young adults, particularly in those exposed to regular salmeterol. There follows the presentation of a proof-of-principle randomised …
-
Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… classical lipolytic geness (LIPE, PNPLA2, MGLL, ADRB2, ADFP, ABHD5), genes controlling lipolysis (INSR, AKT1, PDE3A, PDE3B, PRKAA1, PRKAA2, FOXO1, SIRT1), and other proteins (GHR, CAV1, ADIPOQ, TNF1) was also measured. Dry matter intake, blood glucose and NEFA were not significantly different in …
-
Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… P = 0·003; OPRM1- rs1799971, P = 0·031; ADRB2-rs1042713; P < 0·001; UGT2B7-rs7438135, P = 0·037). The 3·7 kb HBA1/HBA2 deletion correlated with increased VOC (P = 0·002). HbF-promoting loci variants correlated with decreased hospitalisation (BCL11A-rs4671393, P = 0·026; …
-
The role of macrophage intracellular lipid partitioning in glucose and lipid homeostasis during obesity
Obesity-associated metabolic disorders are amongst the most prevalent causes of death worldwide. Understanding how obesity leads to the development of the Metabolic Syndrome (MetS) and cardiovascular disease (CVD) will enable the development of novel therapies that dissociate obesity from its …