Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"adora2b"”.
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Elevated Cochlear Adenosine Causes Hearing Loss Via Adora2B Signaling
… of all four adenosine receptors, adenosine a2b (ADORA2B) was found to have the highest mRNA expression in untreated <em>Ada</em><sup>-/-</sup> cochlea. We observed that genetically and pharmacologically ablating ADORA2B in the <em>Ada</em><sup>-/-</sup> mice attenuated hearing deficiencies and …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
… and subsequent activation of the adenosine 2B (ADORA2B) receptor promotes immune cell invasion, airspace destruction, and fibrosis in chronic lung disease. Additionally, alternatively activated alveolar macrophages (AAMs) expressing ADORA2B, have been implicated in mediating adenosine’s …
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The Role of Adenosine Signaling In Mature Erythrocytes and Erythroid Progenitors
… adenosine signaling via erythrocyte specific ADORA2B coupled with AMP-activated protein kinase is a key mechanism for hypoxia adaptation via induction of 2,3-BPG production with O<sub>2</sub> release to counteract severe hypoxia. 2) Adenosine signaling via erythroid ADORA2B is a previously …
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Role and Regulation of Sphingosine 1-Phosphate In Erythrocyte
… by activating the A2B adenosine receptor (ADORA2B) which then leads to activation of protein kinase A (PKA) and Extracellular Signal Regulated Kinase 1/2 (ERK1/2) signaling pathways. Activated erythrocyte Sphk1 and elevated S1P are beneficial to hypoxia adaptation by promoting erythrocyte …
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Inhibition of adenosinergic signaling in the tumor immune environment: the effect of combination CD73 blockade and oHSV therapy on solid tumors
… expression of the adenosine receptor gene <em>ADORA2B </em>after treatment. The accumulation of eADO in the TME is predominantly the responsibility of ectoenzyme CD73 (<em>NT5E</em>) which catalyzes the hydrolysis of AMP to eADO. High <em>NT5E </em>gene expression, as well as gene signatures …
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Pharmacological targets for treatment of retinal neurodegenerations: new perspectives [Nuove prospettive sui target farmacologici per il trattamento della neurodegenerazione retinica]
… HTR5A, HTR1D, HTR2C e l’adenosinico ADORA2B, hanno mostrato un elevato potenziale di novità come target per il trattamento del glaucoma. Inoltre, i recettori purinergici ionotropici P2X3 e P2X4, insieme agli enzimi codificati da CYP2C8, LDHA e MAOB potrebbero essere degni di …