Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 137 for “"adjuvants"”.
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Behavioural adjuvants to vaccination
This thesis investigated the effects of acute eccentric exercise on the immune response to vaccination in young humans. Study one investigated whether the efficacy of the eccentric exercise intervention was affected by manipulating the timings of exercise prior to influenza vaccination. Three …
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Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… have designed Pfs25 protein-based vaccines with adjuvants, these vaccines do not efficiently elicit transmission-blocking antibodies. We hypothesized Ad5 would serve as a vaccine delivery platform and adjuvant for Pfs25 to generate a robust and prolonged Pfs25-specific antibody response. We found …
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The effect of spray adjuvants on the phytotoxicity of herbicides
Greenhouse and field experiments were conducted on the tolerance of wheat (Tritiaum aestivum L.), barley (Hordeum sativum Jess.), rapeseed (Brassiaa napus L.) and flax (Linum usitatissimum L.) to selected nonionic surfactants (Triton XA, Wex and Renex 36) when applied with herbicides. In the …
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Role of dendritic cells in response to cytokine gene adjuvants
… to improve DNA vaccines is to use cytokine gene adjuvants to recruit DC, such as GMCSF and IL-3. The aim of the work carried out in this thesis was to investigate the effects of GM-CSF and IL-3 after gene-gun vaccination. Initial studies focused on the histological effects of GM-CSF and IL-3 in …
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Enhancement of HIV vaccine efficacy via lipid nanoparticle-based adjuvants
Adjuvants are immunomodulators and/or formulations/delivery vehicles which enhance immune responses to vaccines. The lack of progress in the development of an HIV humoral vaccine is due, in part, to the absence of available adjuvants which can be sufficiently potent with minimal adverse side …
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Enterotoxin B Subunit Lectins as Adjuvants for Improvement of Mucosal Vaccine
… bacterial and plant enterotoxin B subunit adjuvants containing a variety of receptor-binding properties were used to enhance the immunogenicity of rotavirus subunit vaccines. Enterotoxin B subunit adjuvants were employed to enhance protection against virus infection. Pentameric cholera …
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Streptavidin-cytokine fusion proteins for use as adjuvants in cancer vaccines
… streptavidin-cytokine fusion proteins. Immunoadjuvants can augment the weak or non-existent antitumour response of a patient with cancer to immunotherapy. The response of breast cancer patients to cancer vaccines directed against tumour associated antigens, such as HER2/neu, is often weak and …
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Antimicrobial Polymers as Adjuvants/Synergists of Antibiotics to Combat Multidrug-Resistant Bacteria
… were also investigated as potential adjuvants or synergists to potentiate the antimicrobial activity of antibiotics against Mycobacterium smegmatis via a two-component system. Among the different families of antibiotics screened, it was found that these polymers only act as adjuvants …
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Modulation of Allergic Disease through the use of Th1-associated Vaccine Adjuvants
… The first study compared a variety of vaccine adjuvants to identify a potent adjuvant with strong Th1-associated activity. This study verified that the Toll-like receptor (TLR) ligand CpG could induce potent Th1-associated immune responses. The second study tested the ability of environmental …
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Membrane-Bound Immunomodulators As Adjuvants In A Cell Culture-Based Avian Influenza Vaccine
… often generate suboptimal immune responses. Adjuvants are incorporated into vaccines to increase their immunogenicity, however currently available adjuvants have shortcomings which have limited their use in human and veterinary medicine. This necessitates the development of new adjuvants and …
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Impact of Adjuvants on the Antibody Responses to Pre-pandemic H5N1 Influenza Vaccines
… Therefore, the WHO has recommended the use of adjuvants especially the oil‑in‑water emulsions (such as MF59) in combination with H5N1 split or subunit vaccines. While the ability of these adjuvants to generally boost the vaccine-specific antibody titers has been well documented, the question of …
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Exploration of Toll-like Receptor 7 and 8 Agonists as Potential Vaccine Adjuvants
… agonists hold promise as potential vaccine adjuvants, since they directly activate antigen-presenting cells and enhance T helper 1-driven immune responses. A general introduction to TLRs, with an emphasis on the role of TLR7/8 activation in innate and adaptive immune responses is presented …
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Development of a Nanoparticle Vaccine Delivery System with Polymeric Oral Adjuvants for Poultry
… technology has been hindered by a lack of new adjuvants to enable development of protective immunity using different vaccine delivery methods. A vaccine delivery system using oral adjuvants would be applicable across species for both individual and mass vaccination in both the medical and …
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SYNTHESIS AND STRUCTURAL DESIGN OF CARBOHYDRATE-BASED ARCHITECTURES: FROM VACCINE ADJUVANTS TO GLYCAN FOLDAMERS
… synthesis of glycomimetics structures3, vaccine adjuvants4. Polyglycan structures have been used both for biology and for material chemistry purpose5. The first chapter of this PhD thesis focus the attention on vaccine adjuvant semi-synthesis. Vaccines are one of the oldest treatments in medicine …
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
Multiple sclerosis (MS) is an inflammatory disease of the CNS. Infections can trigger or exacerbate the course of MS, and many agents, both bacterial and viral, have been implicated. These agents are recognized by the innate immune system via pathogen-associated molecular patterns (PAMPs) …
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Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy
… innate or adaptive immune responses, immunoadjuvants have become promising tools for cancer immunotherapy. Different types of immunoadjuvants such as toll-like receptor (TLR) agonists, exosomes, and metallic immunoadjuvants have been studied for their immunological effects. However, the …
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Effect of fertilizers and adjuvants on quizalofop, sethoxydim, and thiameturon foliar uptake and weed control
Combinations of urea ammonium nitrate (UAN), ammonium polyphosphate (APP), ammonium sulfate (AS), petroleum oil concentrate (POC), and non-ionic surfactant (SURF) were evaluated as postemergence spray additives to improve giant foxtail (Setaria faberi Herrm.) and volunteer corn (Zea mays L.) …
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