Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"adjuvanticity"”.
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Exploration of Toll-like Receptor 7 and 8 Agonists as Potential Vaccine Adjuvants
… TLR8-dependent NF-kB activation and strong adjuvanticity without proinflammatory cytokine induction (Chapter 3). Combinatorial libraries using the Groebke-Blackburn-Bienaymé reaction have also yielded TLR7/8-inactive, but antibacterial imidazo[1,2-a]pyridines (Chapter 4). Based on the …
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Formulation and characterisation of an effective particulate delivery vehicle for the novel sub-unit vaccine antigen, Ag85B-ESAT-6
… of the system whilst also adding further adjuvanticity. Indeed, this formulation was effective in stimulating both a cell mediated and humoural immune response. In order to investigate an alternative to the DDA-TDB system, microspheres based on poly(DL-lactide-co-glycolide) (PLGA) …
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Bacterial outer membrane vesicles (OMVs) as a platform for personalized cancer vaccines
… with cancer epitopes together with their unique adjuvanticity and safety make them a particularly interesting vaccine platform. In this study, we have demonstrated that immunization of mice with OMVs activate both innate and adaptive immunity and induce a Th1 immune response, fundamental for an …
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Strategies for the induction of mucosal immunity against hepatitis B virus.
… parenterally-delivered proteins. Herein, the adjuvanticity of CpG ODN relative to or in combination with cholera toxin (CT), Escherichia coli heat-labile enterotoxin (LT), the B subunit of CT (CTB) and a non-toxic derivative of LT (LTK63) was evaluated with intranasal delivery. We also …
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Adjuvant Interactions with Lipid Membranes and Their Effect on Cellular Immune Responses
… how lipid-mediated interactions contribute to adjuvanticity, previous studies suggested aluminum-based adjuvants (ABAs) have high affinity for sphingomyelin and cholesterol, which allowed them to activate dendritic cells exclusively through lipid sorting. This dissertation sought to understand …
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Construction and characterization of proteome-minimized OMVs from E. coli and their exploitation in infectious disease and cancer vaccines
… is essential for OMV adjuvaticity, but such adjuvanticity has to be modulated to avoid reactogenicity. In this study, we have addressed the two issues by creating a strain releasing OMVs with a minimal amount of endogenous proteins and containing a detoxified LPS. In particular, we first …
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A study of the contribution of mast cells to vaccination - Regulatory functions of Fc gamma receptors
… not entirely bystanders in CTA1-DD/IgG-mediated adjuvanticity. We discovered that a balanced expression of Fc gamma RIIB and Fc gamma RIIIA was required for mast cells to resist apoptosis mediated by IgG immune complexes. Therefore, MMCs, which only expressed Fc gamma RIIB, but not Fc gamma …
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ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS
… Nevertheless, the efficacy evaluation of CCL28 adjuvanticity requires further experiments to define immune correlates of mucosal responses to vaccination with VLPs in combination with chemokine adjuvants.
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Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal …