Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"adjuvant treatment"”.
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Analysis of markers of cell division cycle, apoptosis and autophagy flux in glioblastoma
… despite advances in surgical and oncological treatments. Currently available treatments include surgical resection, fractionated external beam radiotherapy and chemotherapy. This study aimed to investigate markers of cell division cycle, apoptosis and autophagy flux in an attempt to identify …
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A Theoretical Model Of Breast Tumor Metastases In The Context Of Tumor Dormancy
… a size that does not normally warrant a systemic treatment. Current breast cancer models developed as part of the Cancer Intervention and Surveillance Modeling Network (CISNET) consortium assume that metastasis is a late event when estimating the benefits of cancer control strategies in the U.S. I …
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Clinical Characteristics of Struma Ovarii
… finding was normalized after operative treatment. CA-125 level was elevated in 6 cases. As the findings of Image study, 8 cases were dermoid cyst and only 3 cases were struma ovarii. 4 cases were malignant struma ovarii. There were no recurrent disease. CONCLUSION: Struma ovarii is rare …
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The role of epigenetic changes in chemoresistant breast cancer cells
Cytotoxic chemotherapy is extremely important in adjuvant treatment of breast cancer. Yet, tumours frequently acquire chemoresistance that correlates with increased aggressiveness and poor prognosis. Three theories exist describing how the resistance develops: genetic, epigenetic and karyotypic …
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Working models of attachment and health threats: Distress, appraisal, coping and health-related behaviours in colorectal cancer.
… and female colorectal cancer patients undergoing adjuvant treatment. Health-related behaviours were chosen as behavioural outcomes. Although measurement and design issues did not permit a complete test of the model, the results suggested that working models of attachment are related to distress …
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EVALUATING THE EFFECTS OF FASTING CONDITIONS IN COMBINATION WITH TEMOZOLOMIDE FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME
… GBM is maximal surgical resection followed by adjuvant treatment with the chemotherapeutic agent temozolomide (TMZ) and radiotherapy. O-6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein involved in TMZ resistance. Known as the Warburg effect, cancer cells will preferentially …
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Risk Factors of Tumour Recurrence and Reduced Survival in Rectal Cancer
… is important for optimal, personalised neoadjuvant/adjuvant treatment and follow-up strategies. This thesis identifies potential risk factors of tumour recurrence and reduced survival – i.e., surgery-related and tumour biology-related prognostic factors – in a cohort of patients registered …
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The Impact of Mood Disorders on Cognitive Function in Post-menopausal Women Undergoing Treatment for Early-stage Breast Cancer
… experiencing cognitive difficulties following adjuvant chemotherapy. However, the generalizability of the results of a number of studies that have attempted to document the association between adjuvant chemotherapy and cognitive dysfunction has been limited due to inconsistencies in the …
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Exploring Metallic Flavor Perception: Analysis of Human Salivary Proteins and the Use of the Iron-Binding Protein Lactoferrin in Reducing Metallic Off-Flavors
… and its remediation using pre- and post-rinse treatments of water (control) or metal chelators, were studied. Metal chelators included lactoferrin (1 ?M), a natural metal-binding protein in milk and saliva, and EDTA (36 ?M), a synthetic chelator. Time-intensity (TI) evaluation (n=6, 4 female; …
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Influence of missing explanatory variables and longitudinal assessments in breast cancer clinical trials
Clinical trials in breast cancer assess treatment regimens based on a balance of efficacy and adverse effects. To achieve high-quality evidence for these assessments, it is important to minimise potential sources of bias. Therefore, potential bias in the parameter estimates resulting from missing …
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Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme
… for up to 50% of all gliomas. For decades, treatment of this tumour has been limited to surgery with concurrent radiation and chemotherapy with temozolomide (TMZ). However, recurrence is inevitable and resistance develops rapidly despite aggressive treatment regimens leading to a high …
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Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer
… susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. The main goal of this thesis was to …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
… Recombinant human EPO (rhEPO) is also used in treatment of cancer patients with anemia but some studies have reported negative effects on patient survival. Here we demonstrate a correlation between increased Hb levels and tumor response in patients with metastatic breast cancer and anemia, …
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INTEGRATION OF REDOX-REGULATED SIGNALING AND METABOLISM IN HEAD AND NECK CANCER
… with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Resistance to radiation therapy significantly impacts the ability to achieve local and regional remission to ultimately cure cancer. The disease heterogeneity, …
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The Relationship Between Cancer-Related Fatigue and Upper Extremity Function in Breast Cancer Survivors
… cancer survivors (BCS) following surgery and adjuvant treatment, but these multifaceted entities have traditionally been researched as if they were separately occurring events in the survivor’s recovery. <strong>Objective:</strong> This study examined the relationship between breast cancer …
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Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
… breast cancer patients who would benefit from adjuvant tamoxifen therapy. However, resistance to tamoxifen is often observed and possible mechanisms may be loss or reduction of ER, dysfunctional ER- signaling and ligand independent activation of the receptor. Hypoxia and hypoxia inducible …
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Tamoxifen metabolites can target both aromatase and estrogen receptors
… dependent on estrogen signaling. Drugs for the treatment of ER-positive breast cancer can be divided into three classes: selective estrogen receptor modulators (SERMs), selective estrogen receptor down-regulators (SERDs) and aromatase inhibitors (AIs). However, the efficacy and safety of SERMs, …
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The Lived Experience of Recovery Following Transoral Robotic Surgery (TORS) for Head and Neck Cancer
… patients with head and neck cancer to receive treatment that results in less disfigurement and dysfunction compared with traditional approaches. While TORS research has focused mainly on functional surgical outcomes, a need exists to understand recovery following TORS from the patient …
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Development and Characterization of an Autologous Whole Cell Breast Cancer Vaccine
… progression of non-metastatic disease. Current adjuvant treatments, such as chemotherapy and radiation, have severe side effects and may result in overtreatment and drug resistance. </p> <p>Since greater than 90% of patients are diagnosed between stages I-III and have minimal residual disease …
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Effects of Advanced Radiotherapy techniques on Normal Tissue Toxicity in Breast Cancer
… after breast conserving surgery is an effective adjuvant treatment, but is associated with some long-term side effects and breast tissue toxicities including breast shrinkage, breast fibrosis, skin changes and poor overall cosmesis. These breast-specific complications can have a detrimental …
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