Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"adjuvant therapy"”.
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Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
ALDH isoenzymes are known to impact the sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs. Despite its bone marrow toxicity, cyclophos-phamide is still used to treat various recalcitrant forms of cancer. When activated, cyclo-phosphamide forms aldophosphamide that can …
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Pathologic Markers of Prognosis In Ampullary Carcinoma
… resection of localized disease. The benefit of adjuvant therapy, however, remains unknown in these patients partly because of difficulty in stratifying which patients are at high risk for recurrence. To better identify those patients who may benefit from adjuvant therapy, I conducted a …
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Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) at Red Cross War Memorial Children’s Hospital, Cape Town: A 2-year review
… the respiratory tract, with voice preservation. Adjuvant therapy is indicated in severe cases. Objective: A review of children with JoRRP presenting to the ENT Department at Red Cross War Memorial Children’s Hospital (RCWMCH) over 2 years. Evaluation of the pattern of disease and factors that may …
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The Impact of Mood Disorders on Cognitive Function in Post-menopausal Women Undergoing Treatment for Early-stage Breast Cancer
… experiencing cognitive difficulties following adjuvant chemotherapy. However, the generalizability of the results of a number of studies that have attempted to document the association between adjuvant chemotherapy and cognitive dysfunction has been limited due to inconsistencies in the …
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Identification of Novel CYP2E1 Inhibitor to Investigate Cellular and Exosomal CYP2E1-Mediated Toxicity
… replace DAS as a research tool or as potential adjuvant therapy in CYP2E1-mediated pathologies.</p>
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Practice Patterns and Health Outcomes of Adjuvant Oxaliplatin Chemotherapy for Colorectal Cancer
INTRODUCTION: Oxaliplatin-containing adjuvant chemotherapy improves survival for stage III colon cancer. Yet it is not without harms, most commonly dose-dependent peripheral neuropathy. The 2018 International Duration Evaluation of Adjuvant Chemotherapy (IDEA) trial sought to determine the optimal …
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Low grade gliomas treated at the University of Cape Town Academic Hospital complex: 2001-2017
… location and extent of resection affect outcome. Adjuvant therapy has an important role. Rationale: This study evaluated the demographic data of our patient population, the characteristics of LGGs in our setting, the time to presentation, and the role of adjuvant therapy including more targeted, …
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Weight gain in females with a diagnosis of breast cancer
… II. (c) Women with stage II breast cancer on adjuvant chemotherapy gain more weight than women with stage I or II on Tamoxifen alone. (d) Women with breast cancer who gain weight do not lose it after treatment ends; Findings failed to support null hypotheses a and d, but did b and c. A weight …
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Expression of Survivin : Possible Predictor of Local Recurrence after Curative Resection for Rectal Cancer
… advances in surgical technique(TME) as well as adjuvant therapy(preoperative CCRT). There is a need for better prognostic markers due to the varieties of treatment response within same clinicopathologic stage. Survivin, a novel member of IAP protein, is often associated with increasing …
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Effects of a 12-week walking program on cardiovascular fitness and quality of life in breast cancer patients receiving adjuvant chemotherapy.
… and QOL in breast cancer patients undergoing adjuvant therapy. Methods. Twenty women with histologically proven stage I--II breast cancer were randomized into either an experimental or control group. The patients began the program the same week that they began their chemotherapy treatments. …
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Effects of duration of selected music as an intervention on postoperative pain in open-heart surgery patients during chair rest on the first postoperative day
… power to test the usefulness of music as an adjuvant therapy in reducing postoperative pain.</p>
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Effects of inulin supplementation on markers of mineral and bone metabolism and the gut microbiota in hemodialysis patients
… fiber, represents a feasible and low-cost co-adjuvant therapy for the treatment of MBD in HD patients. Therefore, the objective of this dissertation is to examine the effects of the supplementation of inulin on bone and mineral metabolism and the gut microbiota in HD patients.
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Radioresistance in oral squamous cell carcinoma
… can be successfully treated with surgery or radiotherapy. Despite this most small tumours of the oral cavity are now treated with surgery as the primary treatment modality with radiotherapy being reserved for adjuvant therapy, palliation or in patients unfit for surgery. Radiotherapy is also used …
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Implantação de práticas seguras para o uso de medicamentos no Hospital Napoleão Laureano : elaboração de um guia farmacoterapêutico para a utilização dos MPP
… The cancer patients makes use of various drugs, adjuvant therapy, in addition to used in cancer treatment and therefore the focus of your treatment ends up being the chemotherapy, and not classified as anticancer drugs, which are also potentially dangerous is not given to due attention should be …
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Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors
… molecule drugs against GATA-1 may be used as an adjuvant therapy for metabolic targeting of malignant glioma.</p>
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EVALUATING THE EFFECTS OF FASTING CONDITIONS IN COMBINATION WITH TEMOZOLOMIDE FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME
… GBM is maximal surgical resection followed by adjuvant treatment with the chemotherapeutic agent temozolomide (TMZ) and radiotherapy. O-6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein involved in TMZ resistance. Known as the Warburg effect, cancer cells will preferentially …
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Incidence of atrophic rhinitis after endoscopic sinonasal surgery : a retrospective review
… tumour (n=19) and patients who had received adjuvant radiotherapy (n=17) had a statistically significant chance of developing symptoms and signs suggestive of atrophic rhinitis over time. Variables such as age, gender, extent of surgery, bilateral disease, benign or malignant tumour, were not …
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Germline Genetic Modulator of Cancer Metastasis
… clinical decision and the use of appropriate adjuvant therapy, thus having a profound impact on patient survival. A central dogma in cancer is that during tumorigenesis, cancer cells acquire somatic mutations that regulate metastatic likelihood during evolution of the primary tumor. However, …
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Inhibition of the autophagy pathway modulates osteosarcoma chemoresistance
… bone tumour. Although the introduction of chemotherapy has improved the survival rate of osteosarcoma patients, chemoresistance remains a major clinical problem underlying poor survival outcome. Previous studies have shown that deregulation of a cell survival process called autophagy is closely …
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