Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"adjuvant chemotherapy"”.
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Does the Timing of Adjuvant Chemotherapy for Gastric Cancer Influence Patient Outcome?
PURPOSE: Although adjuvant chemotherapy is currently established as standard treatment in stage II/III gastric cancer, there is no report about the optimal timing of the initiation of chemotherapy. We investigated the effect of the interval between surgery and the start of chemotherapy on patient …
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
Background:Neoadjuvant chemotherapy is a standard treatment for locally advanced breast cancer however chemoresistance can be a major obstacle in ER+ cancers. Using comparative proteomic approaches (antibody microarray/AbMA and 2D-PAGE with MALDI-TOF/TOF MS) to investigate a pilot series of breast …
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The lived experiences of six women during adjuvant chemotherapy for Stage I or II breast cancer
There is no abstract available for this dissertation.
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Pathological response of breast cancer to neo-adjuvant chemotherapy at a single tertiary centre with no access to Trastuzumab
Introduction: Neoadjuvant chemotherapy (NACT) has firmly solidified its status as the gold standard in the treatment of breast cancer for eligible patients. While prevailing guidelines advocate for a combined approach involving chemotherapy and Trastuzumab for individuals with HER2-positive breast …
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Effects of a 12-week walking program on cardiovascular fitness and quality of life in breast cancer patients receiving adjuvant chemotherapy.
… and QOL in breast cancer patients undergoing adjuvant therapy. Methods. Twenty women with histologically proven stage I--II breast cancer were randomized into either an experimental or control group. The patients began the program the same week that they began their chemotherapy treatments. …
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The economic and clinical outcomes and policy implications of gene expression profiling in breast cancer care
… recommended by clinical guidelines to receive adjuvant chemotherapy to prevent disease progression and increase survival. However, low-risk patients may be experiencing the side effects of chemotherapy, with no corresponding benefit, which may also lead to spending on unnecessary treatment by …
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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
… surgery is the mainstay treatment for HNPCC. Adjuvant chemotherapy and radiotherapy are often used to reduce systemic and locoregional recurrence, respectively, after curative surgical resection. The main chemotherapeutic agent is 5-Fluoroucacil (5-FU). Studies have attempted to elucidate …
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The Impact of Mood Disorders on Cognitive Function in Post-menopausal Women Undergoing Treatment for Early-stage Breast Cancer
… experiencing cognitive difficulties following adjuvant chemotherapy. However, the generalizability of the results of a number of studies that have attempted to document the association between adjuvant chemotherapy and cognitive dysfunction has been limited due to inconsistencies in the …
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Molecular Determinants of Residual Disease In Ovarian Cancer
… is primary cytoreductive surgery followed by adjuvant chemotherapy. Residual disease followed by surgery is associated with adverse overall and progression-free survival as well as poor response to adjuvant chemotherapy. Accurate identification of patients at high risk of residual disease will …
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Ανάπτυξη και κλινικές εφαρμογές μεθόδων μοριακής διαγνωστικής για την ανίχνευση κυκλοφορούντων καρκινικών κυττάρων στον καρκίνο του μαστού μέσω της έκφρασης της μαστοσφαιρίνης α
… breast cancer before the administration of adjuvant chemotherapy and 39 patients with metastatic breast cancer. The method is highly specific since the developed assay is free from genomic DNA interferences. Mammaglobin A-mRNA positive cells were detected in 14/101 (13.9%) of early breast …
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Practice Patterns and Health Outcomes of Adjuvant Oxaliplatin Chemotherapy for Colorectal Cancer
INTRODUCTION: Oxaliplatin-containing adjuvant chemotherapy improves survival for stage III colon cancer. Yet it is not without harms, most commonly dose-dependent peripheral neuropathy. The 2018 International Duration Evaluation of Adjuvant Chemotherapy (IDEA) trial sought to determine the optimal …
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Kasos adenokarcinomos diagnostinių ir prognostinių biožymenų paieška /
… cancer patients after radical treatment and adjuvant chemotherapy. Increased CEA and CA19-9 concentrations showed no significant dependencies with survival. Thus, CEACAM6 is a promising new biomarker with significant prognostic value and prediction of chemoresistance properties, enabling the …
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Immune Landscape of early liver metastatic lesions in a Novel Immunocompetent Murine Colorectal Cancer Metastasis Model
… patients, with failure rates of surgery and adjuvant chemotherapy between 5% to 40% depending on stage of disease. In our study, we simulated MRD using genetically engineered organoids with precise somatic editing of APC and TP53, creating a murine model that mimics human liver metastatic …
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Weight gain in females with a diagnosis of breast cancer
… II. (c) Women with stage II breast cancer on adjuvant chemotherapy gain more weight than women with stage I or II on Tamoxifen alone. (d) Women with breast cancer who gain weight do not lose it after treatment ends; Findings failed to support null hypotheses a and d, but did b and c. A weight …
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Profiling mucinous ovarian cancer and comparisons with tumours of the gastro-intestinal tract: identification of markers for diagnosis, prognosis, and treatment targets.
… Stage I MOC are at risk of relapse and require adjuvant chemotherapy; 2) accurately diagnosing primary MOC from a cancer that has started elsewhere and spread to the ovary, most commonly from a gastrointestinal (GI) site; and 3) finding better treatment options for patients with advanced stage …
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer
… respond to treatment with debulking surgery and adjuvant chemotherapy, most will have residual disease and relapse. Depending on the extent of metastatic spread and the size of nodal lesions, complete surgical removal of solid tumor may be impossible. Adjuvant chemotherapy is often associated …
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Wilms' tumour outcomes at Red Cross Children's Hospital 1979-2003
… surgery, in the form of nephrectomy, followed by chemotherapy. A small number of these tumours are bilateral and here surgery has evolved from simple nephrectomy into the use of nephron-sparing techniques. METHODS: A retrospective analysis was performed on all patients diagnosed with Wilms' tumour …
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A Theoretical Model Of Breast Tumor Metastases In The Context Of Tumor Dormancy
… model structure allows for the quantification of adjuvant treatment benefits based on the heterogeneity of metastasis process. To solve the problem of modeling two interdependent processes that evolve at different time scales, theoretical distributions of time to key clinical events are derived …
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Modular prosthetic reconstruction for primary bone tumours of the distal tibia in ten patients
… The patients with osteosarcoma had neo-adjuvant chemotherapy before surgery. Function was assessed by the Musculoskeletal Tumor Society (MSTS) score. Results: There were six females and four males, with a mean age of 31 (12-75) years. Two patients had local recurrence treated with a BKA …
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Ependymal tumours in childhood: outcomes and prognostic factors
… patients (43,1%). Thirtyeight patients received adjuvant radiotherapy (76,5%) and 10 (19,6%) received adjuvant chemotherapy. RESULTS: The 5-year overall survival (OS) was 63,3 % (median follow up of 46 months). The 5 year progression free survival (PFS) was 50,70%. Seventeen (33,3%) patients …
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