Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 461 for “"adipose tissue"”.
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ADIPOSE TISSUE GROWTH AND MAINTENANCE
… new importance. Characterized by an increase in adipose tissue to the point where it is associated with adverse health effects, the prevalence of obesity has nearly tripled over the past fifty years. Though for many years adipose tissue was considered to be merely a storage depot for fatty acids, …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… response in burns is the role of the adipose tissue. Humans harbour two distinct adipose depots, white adipose tissue (WAT) and brown adipose tissue (BAT) that carry out essentially opposite functions. WAT is primarily involved in storing excess energy, whereas BAT burns excess energy …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… the cellular composition and phenotype of white adipose tissue (WAT). Nonetheless, the identity of progenitors that contribute to this cellular plasticity in vivo remains poorly understood. Utilizing genetic lineage tracing techniques in combination with in situ imunohistochemical analysis, we …
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White Adipose Tissue Remodeling by Intermittent Fasting
… regulator of energy balance, understanding white adipose tissue (WAT) homeostasis and its response to dietary challenges is crucial to reveal the mechanisms of IF-mediated metabolic benefits. Particularly, recent studies highlighted the role of dysfunctional adipocyte progenitors (APs) in …
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Enhancement of Hiv Persistence By Adipose Tissue
… T cells and macrophages, traffic into various tissues where most viral replication occurs, or in the case of virally-suppressed antiretroviral-treated patients, the virus becomes dormant and protected from drugs and immune responses. The major tissue reservoirs for HIV include lymphoid tissues …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… and chronic activation of immune cells into adipose tissue as well as many other tissues such as liver, skeletal muscle and pancreas. Therefore, targeting immune cells to reduce inflammation is an important weapon to treat obesity related syndrome. Interestingly, deficiency of fatty acid …
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Characterization of porcine adipose tissue-derived stem cells
… not been identified in stem cells from porcine adipose tissue, an easily attainable tissue resource. The phenotypic profile of cell surface proteins and chromosomal stability of porcine adipose tissue-derived stem cells (pASCs) through in vitro culture have not been described. Also, research has …
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Obesity, visceral adipose tissue, and cognition in childhood
… In addition to weight status, central adipose tissue is particularly dangerous, with visceral adipose tissue being linked to higher risks of metabolic diseases and cardiovascular complications. However, the relationship between central adiposity and brain health and cognition during …
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The role of the mitofusins in adipose tissue
Monogenic mitochondrial disease is known to cause tissue-selective manifestations, typically affecting the nervous system, liver, and muscle. However, until recently, there was relatively little human genetic evidence for a role of mitochondria in disorders of energy balance (i.e. weight) or …
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THE ASSOCIATION OF VISCERAL ADIPOSE TISSUE WITH PULSE PRESSURE
Background: Obesity and aortic stiffness (AS) contribute to cardiovascular disease (CVD). Central obesity as measured by VAT is thought to be a more specific measure of deleterious adiposity independent of body mass index (BMI). However, the nature of the relationship between VAT and AS in …
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The Aging-Induced Decline in Beige Adipose Tissue Development
… and obesity are associated with dysfunctional adipose tissue leading to the pathogenesis of numerous comorbidities including heart disease, type 2 diabetes, and numerous cancers. Unlike energy-storing white adipose tissue, beige adipose tissue burns energy in the form of heat and thus has …
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Hormone-Sensitive Lipase - New roles in adipose tissue biology
… the HSL gene in mice, with a focus on the white adipose tissue (WAT). The initial study demonstrated a mild insulin resistance in multiple tissues of the HSL null mice, which was almost fully compensated for by increased insulin secretion by the pancreatic beta-cells. The HSL null mice were …
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Interventions against obesity through increased lipolysis in adipose tissue
… intervention against obesity in which adipose tissue lipolysis will be combined with increased energy expenditure: the approach is also designed to consider agents that will benefit glycaemic control in coexistent obesity and diabetes by improving insulin sensitivity. Rodent and human …
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Mechanisms of growth hormone inhibition of adipose tissue growth
… body and muscle growth but also inhibits adipose tissue growth. The overall objective of this study was to determine the mechanisms by which GH inhibits adipose tissue growth. Three studies were conducted to achieve this objective. The first study was conducted to determine if GH inhibits …
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Role of adipose tissue as an endocrineorgan in systemic inflammation
… has spurred multidisciplinary research into adipose tissue and importantly, the molecular biology of the adipocyte. The concept of adipose tissue as an endocrine organ, in addition to an energy storage compartment, is now pivotal in linking excess adiposity to disease states. Recent studies …
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Regulation of Visceral Adipose Tissue Development and Remodeling in Obesity
Page xiiii is misnumbered as page xiv.
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A Network Approach to Understanding miRNA Regulation in Adipose Tissue
<p>Adipose tissue is a complex organ that is essential for lipid storage and energy homeostasis in mammals. While transcription factors that govern adipogenesis, inflammation, non-shivering thermogenesis, and endocrine function in fat tissue have been well-described, comparatively less attention …
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Characterization of human adipose tissue-derived adult multipotent precursor cells
… a putative subpopulations of stem cells in the adipose tissue stroma. These adipose derived stem cells (ADSCs) under certain conditions express characteristics of various mesenchymal lineages. This thesis showed that 1,25a??dihydroxyvitamin D3 worked synergistically with I?-glycerophosphate and …
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