Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"adipocyte metabolism"”.
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Effects of Neuropeptide Y on Adipocyte Metabolism
… obesity. However, the role of NPY in regulating adipocyte metabolism is poorly understood. The present study examined the effects of NPY on adipocyte metabolism using 3T3-L1 adipocytes. We found that NPY potentiated isoproterenol (P-adrenergic agonist) stimulated lipolysis. This potentiation …
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Protein kinases in hormonal regulation of adipocyte metabolism.
… whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. Adipocytes also take up fatty acids from the …
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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation
… Mitochondria, central to ATP production, lipid metabolism, and thermogenesis, play a crucial role in modulating white adipose tissue metabolism. This thesis explores an innovative strategy for addressing mitochondrial dysfunction in obesity which is a critical aspect of this multifactorial …
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The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… In normal adipose tissue, FOXC2 regulates adipocyte metabolism by promoting the expression of genes associated with energy turnover, insulin sensitivity, differentiation, and mitochondrial biogenesis. I hypothesized that similar to its regulatory role of adipocyte metabolism, FOXC2 dictates …
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Investigation of S1P and S1P Signaling in Adipocytes and Adipocyte-Breast Cancer Cell Interaction
… risk and progression, and high accumulation of adipocytes is increasingly recognized as an active facilitator in the interaction between the tumor and the adipose tissue in the breast. Adipocytes may act as a therapeutic obstacle and can be viewed as a target in breast cancer, as they affect …
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The Functional Cellular Identity and Interconversion of Human White, Beige, and Brown Adipocytes
… brown adipose tissue activity in human adults, adipocyte thermogenesis has received significant interest due to its therapeutic potential for reversing obesity, or in assisting orthogonal treatment approaches. However, while metabolic changes in the form of increased energy expenditure in …
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The effects of culture conditions on cell metabolism and function
… cultured cells. Here, we demonstrate that 3T3-L1 adipocytes accumulate large amounts of odd-chain fatty acids *in vitro*. Since vitamins B7 and B12-dependent enzymes regulate the activity of several pathways that converge at the point of lipid metabolism, we further show that the addition of both …
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DIETARY BIOACTIVES IN THE MODULATION OF METABOLIC, FUNCTIONAL AND AGING BIOMARKERS
… with a focus on the mechanisms involving lipid metabolism, oxidative stress and inflammation, intestinal permeability, and telomere integrity. The research was structured into three main chapters, combining both in vitro and in vivo approaches. In Chapter 1, the mechanisms of action of selected …
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STUDY ON HISTONE DEACETYLASE 3 AND ITS PHARMACOLOGICAL REGULATION IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE
… as a strategy to tackle obesity. Epigenetics and metabolism are closely intertwined in both physiological and pathological conditions. Histone deacetylases (HDACs) are epigenome modifiers regulating adipocyte metabolism. Our previous studies with chemical inhibitors or genetic alterations of HDAC3 …
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Hormone Induced Magnesium Transfer in Fat Cell Plasma Membranes: A Mechanism for Effecting Changes in Cellular Metabolism
… concentration could account for changes in metabolism seen during lipolytic hormone stimulation of adipocytes.</p>
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1,25-Dihydroxyvitamin D Regulation of Triacylglycerol Accumulation in Differentiated Adipocytes
… whether vitamin D impacts lipid storage and metabolism in terminally differentiated adipocytes is not yet known. The purpose of this work was to determine the impact of 1,25-dihydroxyvitamin D (1,25(OH)2D), the bioactive vitamin D metabolite, on triacylglycerol accumulation and lipid and …
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Regulation of Akt ignal transduction by glucose metabolism
… Intriguingly, the expression of PFKFB3 in adipocytes is extremely high compared to most other tissues. I observed an insulin-dependent induction of aerobic glycolysis in adipocytes through lactate production and hypothesised that this phenomenon is critical for adipocytes to enter the …
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Dynamic subcellular proteomics identifies novel regulators of adipocyte insulin action
Insulin acts on adipocytes to control whole-body lipid and glucose metabolism. Following binding to its receptor on adipocytes, insulin activates a signalling cascade that promotes glucose uptake and inhibits lipolysis. These processes rely on changes in protein localisation. For example, insulin …