Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"adipocyte differentiation"”.
-
MicroRNAs: Tissue Expression and Role in 3T3-L1 Pre-Adipocyte Differentiation
… whether microRNAs regulate 3T3-L1 pre-adipocyte differentiation. The expression of microRNAs during 3T3-L1 pre-adipocyte differentiation was detected by microarrays and confirmed by northern blot and quantitative real time PCR. Several microRNAs, including let-7, were up-regulated at …
-
Interaction between positive- and negative- regulatory elements in the first intron controls transcription of the glutamine synthetase gene during adipocyte differentiation
Expression of a number of genes during cellular differentiation is controlled at the level of transcription. Cell type- and time-specific patterns of gene transcription result from the interaction between cis-acting elements and trans-acting factors. In order to understand the molecular mechanisms …
-
Investigating the Role of the PGF2 Alpha/Calcineurin-Signaling Pathway in the Regulation of Adipogenesis
… is a potent physiological inhibitor of adipocyte differentiation. In previous studies, we demonstrated that PGF2α inhibits adipogenesis via activation of the calcium-regulated protein phosphatase, calcineurin. In this current study, we have now extended these findings to identify …
-
Longitudinal gene networks, canonical pathways and functional analysis of microarray data from Longissimus thoracis et lumborum muscle samples of early-weaned Angus steers
… which showed to have a role on myogenesis and adipocyte differentiation. The outcome of this study was that the administration of starch in the diet of early weaned steers early in life, was expressed in higher scores for intramuscular fat deposition compared with normal weaned steers that …
-
Studies on the mode of action of dermonecrotic toxins: Effects on adipogenic signaling pathways and delivery of c-terminal cargo into the cytosol
… toxin in adipogenesis and the effects on adipocyte differentiation, and (2) PMT-mediated delivery of its cargo. In this work we demonstrate the involvement of dermonecrotic toxins in adipogenesis. We show that treatment with any one of the dermonecrotic toxins blocked adipogenesis and …
-
Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… is converted to triglycerides and stored in adipocytes for further usage. Lipid accumulation within adipocytes is under the control of a cascade of transcription factors that interact with histone acetyltransferases and deacetylases. We show that histone deacetylase inhibitors efficiently …
-
THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… genistein and daidzein were reported to induce adipocyte differentiation through potential interactions with PPARγs, canonical WNT proteins, and estrogen receptors (ER) signaling. The current investigation was conducted to test the effects of synthetic and natural estrogenic compounds (BDDA, …
-
Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
… superfamily. PPARγ regulates genes involved in adipocyte differentiation, insulin homeostasis, neuroprotection and anti-inflammation. As such, PPARγ is under consideration as therapy for ischemic stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis and traumatic brain injury. …
-
Role of appetite-regulating peptides in adipose physiology in broiler chicks
… was thus to evaluate effects of NPY on chick preadipocyte proliferation and differentiation. Preadipocytes were treated with NPY and gene expression and cellular proliferation were evaluated. Cells were also treated with NPY during differentiation and harvested during the later stages. With …
-
METABOLIC ADVERSE EFFECTS INDUCED BY SECOND GENERATION ANTIPSYCHOTIC DRUGS IN PEDIATRIC PATIENTS: PHARMACOGENETIC PROFILING AND MECHANISTIC ANALYSIS OF GENETIC VARIANTS EFFECT IN VITRO MODELS
… the cell culture condition for the adipogenic differentiation process. Then, to clarify the mechanisms by which SGAs induce weight gain we studied the risperidone effect on the adipogenesis of SW872. We observed that risperidone directly promoted adipocyte differentiation and lipid …
-
STUDY ON HISTONE DEACETYLASE 3 AND ITS PHARMACOLOGICAL REGULATION IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE
… (HDACs) are epigenome modifiers regulating adipocyte metabolism. Our previous studies with chemical inhibitors or genetic alterations of HDAC3 have shown metabolic rewiring of white adipocytes towards browning via the activation of a futile cycle of lipolysis and lipogenesis. Obesity is …
-
Effects of weaning age and maternal nutrition on gene expression of longissimus muscle of beef steers
… b) miR-143 that inhibits DLK1 that inhibits adipocyte differentiation through ERK1/2 activation, c) miR-21 that impaired TGFBR2-induced inhibition of adipocyte differentiation and seems to be related to serum adiponectin concentration. Furthermore, from the selected antiadipogenic miRNAs, cow …
-
ADIPOSE TISSUE GROWTH AND MAINTENANCE
… is currently attributed to two mechanisms: adipocyte hypertrophy, the process by which preexisting fat cells increase in size due to an accumulation of lipids, and adipocyte differentiation from fat precursor cells. Stem cells are defined by the ability to self-renew and differentiate into a …
-
Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
… and the adipogenic transcription program during adipocyte differentiation. Nuclear NAD+ is depleted by the induction of cytoplasmic NMNAT-2, whose levels rapidly increase concomitantly with glucose metabolism during differentiation. Competition between nuclear NMNAT-1 and cytoplasmic NMNAT-2 for …
-
Regulation of PPARgamma Activity by mTOR in Adipogenesis
… I show that mTOR plays a critical role in adipocyte differentiation and the maintenance of mature adipocytes, and that its kinase activity is required. Rapamycin specifically disrupted the positive transcriptional feedback loop between C/EBPalpha and PPARgamma. The PPARgamma activity toward …
-
Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
My work focused on understanding adipocyte function and regulation because of the importance to diabetes. In addition to being a fat storage depot, adipose tissue is an endocrine tissue. Adiponectin and leptin are two adipokines that control insulin sensitivity and energy balance. In spite of their …
-
NOVEL ROLES FOR GRK2 IN METABOLIC HOMEOSTASIS AND SKELETAL MUSCLE PHYSIOLOGY
… neonatal rat ventricular myocytes enhances adipocyte differentiation in vitro. These results suggest that the heart produces a secreted factor to control whole body metabolism, and that GRK2 is a regulator of this mechanism.
-
The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… and animal model. Effects of osteoblastic differentiation were measured by alkaline phosphatase (ALP) activity, osteopontin (OPN) protein expression and mineral nodule formation in dexamethasone (DEX)-treated MC3T3-E1 cells and primary bone marrow mesenchymal stem cells (BMSCs). Five …
-
FoxO1 in the regulation of adipocyte autophagy and biology
… from increased adipogenesis (hyperplasia) and adipocyte size (hypertrophy) . Emerging evidence underscores autophagy as an important mediator of adipogenesis and adiposity. We are interested in the upstream regulator of adipocyte autophagy and how it impacts adipocyte biology. Given that …
Page 1 of 2