Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"adhesion and invasion"”.
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A study of p120-catenin and its tyrosine phopshorylation in cancer cell adhesion and invasion
Abstract available p i.
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Intramuscular immunization of mice with KatA (catalase) generates functional antibodies against Campylobacter jejuni invasion of gut epithelial cells in vitro
… of drug resistance in clinical isolates, and the recent association of C. jejuni infections and Guillain-Barré syndrome has heightened the need to develop effective anti-Campylobacter vaccines. Due to the risk of auto-immunity, vaccination using inactivated whole-cells or attenuated cells …
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Characterization of subtilisin-like serine proteases in trichomonas vaginalis
… confirm the importance of subtilases for adhesion and invasion. Serine protease inhibitor assays show that 3,4 DIC and TPCK inhibited cell growth from 79.6 to 98.4% respectively. To examine subtilases in more detail, a number of putative subtilases were cloned from <em>T vaginalis</em>. …
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Fatty Acid-Mediated Inhibition of Host Cell Invasion by Cryptosporidium Parvum
… that inhibits Cryptosporidium parvum sporozoite invasion of host cells in vitro. A panel of similar lipids with varying chain lengths and degrees of saturation were tested for evidence of inhibitory activity in order to determine the range of specificity. We identified a subset of inhibitory …
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Genome sequence of the hyperinvasive Campylobacter jejuni strains
… in humans. Although motility, toxin production, adhesion and invasion are some of the key factors associated with C. jejuni pathogenesis, their mechanism in the disease process remains unclear. The key aim of this project is to study the genetic basis of hyperinvasiveness in a group of six C. …
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Phenotypic, Physiological and Growth Interactions among Salmonella Serovars
… to humans <strong>(chapter 1)</strong>. Understanding the growth of <em>Salmonella</em> serovars and strains is an important basis for more in depth research. In this case we studied <strong>a)</strong> the aerobic and anaerobic growth responses of multiple strains from six different serovars, …
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Protein glycosylation in the gram-negative gamma proteobacterium photorhabdus luminescens
… Photorhabdus luminescens produces glycoproteins and thus contains a protein glycosylation system. P. luminescens is a pathogen of insects and a symbiont of soil nematodes. Adhesion and invasion are very important in the life cycle of the organism and it is speculated that the bacteria may produce …
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Investigating the potential of Sodium Butyrate to Control Salmonella Enteritidis in Poultry
… in humans. Despite using various pre-harvest and post-harvest intervention strategies to reduce Salmonellosis, SE infection is still an extensive problem in the poultry industry with increased incidences since SE has developed multiple strategies to adapt in the chicken intestinal tract …
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The invasin IbeA and its role in Adherent-Invasive Escherichia coli (AIEC) pathogenesis
… coli (AIEC) ∆ibeA mutant was constructed and characterized, and its effect on AIEC adhesion and invasion of intestinal epithelial cells evaluated. The role that this outer membrane protein, IbeA, plays in intra-macrophage survival was also assessed. Compared to the wild-type, AIEC ∆ibeA …
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Cryptosporidium Parvum Microbial Adhesion: Interactions Between Sporozoites and Host Cells
… a significant protozoal pathogen of both humans and animals worldwide. Since little is known about the mechanisms of attachment and invasion of C. parvum sporozoites to host cells, our goal was to elucidate the mechanism of sporozoite recognition of receptors on the host cell membrane. Knowledge …
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Directed Evolution of Glycan-Binding Proteins
… making them widely used tools for basic research and clinical applications. Existing glycan recognition reagents,antibodies and lectins, are limited, and discovery or creation of reagents with novel specificities is time consuming and difficult. This thesis details the generation of novel GBPs …
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Development of exosome-based anti-cancer therapeutics
… responsible for cancer progression, metastasis, and angiogenesis via cellular communications. However, studying cancer derived exosomes in vitro is limited, due to the way cell lines are grown in medium supplemented with foetal bovine serum (FBS) that contains naturally occurring exosomes. …
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Biomechanical regulation of cancer metastasis
… deaths. As such, it is critical to understand the processes that control the spread of cancer through the body. To metastasize, cancer cells must leave the primary tumor, access the circulatory system, adhere to the endothelium of the metastatic site, and migrate out into the surrounding …
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Phenotypic, Genotypic, and Pathogenic Evaluation of E. coli ST131 Clinical Isolates
… isolates have become a major cause of cystitis and pyelonephritis. However, these strains are not known to encode different, or increased numbers of virulence factors compared to other sequence types of pathogenic E. coli. To date, no data in the literature can entirely explain the global …
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Contributions of type 2 IP3 receptors to intercellular adhesions and invasion of glioblastoma cells
Glioblastoma multiforme (GBM) is the most common and invasive brain tumour in adults. Treatment options are limited with a median survival of 15 months and only 12% of patients survive for more than 5 years. A challenge in GBM treatment is that cells infiltrate brain tissue, making complete …
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The role of poi as a naturally fermented Hawaiian food in the modulation of gut health
… diet, is traditionally made from cooked taro and can undergo natural fermentation by lactic acid bacteria (LAB). Previous studies have suggested potential health benefits of poi, such as its prebiotic, probiotic, and anti-cancer properties. However, the specific health advantages and the …
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Analyse des Transkriptionsprofils von Neisseria meningitidis während der Infektion von Epithel- und Endothelzellen unter Verwendung der Mikroarraytechnologie
… zu einer signifikanten Erhöhung der Adhärenz und Invasion nach Infektion von Epithelzellen. Untersuchungen des Infektionspotential für HBMEC Zellen ergaben keine signifikant veränderte Adhärenz und Invasion. Bei zusätzlicher Deletion von rfaF in einem opc negativen Stamm konnte eine Abnahme der …
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Early pathogenesis of Yersinia ruckeri infections in rainbow trout (Oncorhynchus mykiss, Walbaum)
… of yersiniosis or enteric redmouth disease (ERM) and causes significant losses in salmonid aquaculture worldwide. Although infection with this agent has been reported in other fish species, salmonids and especially rainbow trout are most susceptible to ERM. Vaccination of fish with a commercial Y. …
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Role of Staphylococcus aureus GapC and GapB in immunity and pathogenesis of bovine mastitis
Mastitis is the most prevalent and major cause of economic losses in dairy farms. Bovine mastitis caused by strains of S. aureus is a major economically important disease affecting the dairy industry worldwide. S. aureus is one of the most common udder pathogens that cause either clinical or …