Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"adhesins"”.
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Ester bond formation in bacterial adhesins
In the last decade, two new intramolecular covalent bonds were discovered in elongated, single molecule wide surface proteins that markedly changed our view of protein stability. Intramolecular isopeptide bonds were first discovered in 2007 in a surface adhesin from the Gram-positive bacterium …
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Haemophilus influenzae adhesins and the innate immune response
… several outer membrane proteins of which the adhesins play an important role in the initial interactions with the airway epithelium. In this thesis, we have studied two Haemophilus influenzae adhesins and their interactions with innate defense mechanisms. Vitronectin is a glycoprotein that …
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Computational Discovery of Bacterial Fibrillar Adhesins and Adhesive Domains
Fibrillar adhesins are filamentous bacterial surface proteins, which can play a key role in host-pathogen interactions. They have a characteristic protein architecture with repeating domains, called stalk domains, folding into a rod-like stalk structure. An adhesive domain is positioned at the tip …
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Investigating the Role of Trimeric Autotransporter Adhesins in Fusobacterium nucleatum Pathogenesis
… nucleatum virulence have uncovered two surface adhesins, Fap2 and FadA, that interact with the surface of human cells; however, the study of new virulence factors was previously limited as there was no gene deletion system available to functionally analyze F. nucleatum proteins. Interestingly, …
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The Role of Force-Sensitive Interactions in Amyloid Assembly by Fungal Adhesins
… using surface-localized adhesin proteins. Some adhesins also help maintain biofilm integrity by forming fibrous protein aggregates that are linked together by non-covalent bonds between a hydrophobic segment of their sequence, termed the amyloid-forming region (AFR). At the core of these adhesin …
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APPROACHES TO IDENTIFY SURFACE PROTEINS OF ANAPLASMA PHAGOCYTOPHILUM DENSE-CORED ORGANISMS AS ADHESINS TO HUMAN P-SELECTIN GLYCOPROTEIN LIGAND-1
… and thus its survival. However, the bacterial adhesins mediating this process have yet to be identified. In this study, we sought to identify surface proteins of A. phagocytophilum as putative adhesins. A. phagocytophilum undergoes a biphasic developmental cycle, transitioning between a smaller …
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STRUCTURAL AND FUNCTIONAL CHARACTERISATION OF MUCUS ADHESION PROTEINS OF LACTOBACILLUS REUTERI
… between the gut microbiota and the host. Mucus adhesins are thought to be key mediators in the mucus adhesion of commensal Lactobacillus species. However, knowledge on the structural or functional basis of adhesin interaction with mucin glycoproteins, the main component of mucus, is limited. …
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The Staphylococcus Pseudintermedius Adhesin Spsd Contains A Central Fibronectin-Binding Domain
… however, very little is known about its surface adhesins. Surface adhesins in <em>S. aureus</em> are significant contributors to pathogenesis. <em>S. pseudintermedius</em> encodes the surface protein SpsD, which contains characteristics of the microbial surface components recognizing adhesive …
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Investigating bacterial adhesion proteins as tools for controlling bacteria-surface interactions
Adhesins are cell-surface proteins that initiate target binding and surface colonization by bacteria on the path to infection and biofilm formation. A deeper understanding of the interactions between adhesins and their ligands may lead to the development of strategies for controlling infection and …
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Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix
… was to specifically identify the collagen type I adhesins and proteases in the common research strain, B. fragilis 638R, as well as in 23 clinical isolates from Groote Schuur Hospital (GSH), Cape Town.
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Recombinant Mucins with Tailored Glycosylation as Bacterial Toxin Inhibitors
… carbohydrate-binding bacterial toxins, microbial adhesins, viral surface proteins, and antibodies. In paper I and IV, genetically engineered CHO cells were used to produce PSGL-1/mIgG2b carrying the functional carbohydrate receptors of Shiga toxin 1 and 2 (Stx1 and Stx2) and C. difficile toxin A, …
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Regulation of Toxoplasma Motility by Calcium-Dependent Protein Kinases
… relies on the directional translocation of adhesins via an actomyosin motor complex anchored in a vesicular network underlying the plasma membrane of the parasite. A variety of stimuli can trigger calcium increases in the parasite cytoplasm initiating motion, in part by regulating the …
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Comparative and Functional Genomic Studies of Histophilus somni (Haemophilus somnus)
… glycosyltransferases, kinases, helicases, and adhesins have been identified in H. somni. Most of the H. somni strain-specific genes were found to be associated with prophage-like sequences, plasmids, and/or transposons. Therefore, it is likely that these mobile genetic elements played a …
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The streptococcal collagen-like protein-1 (Scl1) is a multifunctional adhesin in extracellular matrix interactions, biofilm formation, and host colonization by group A Streptococcus
… biofilm is often mediated by bacterial surface adhesins and has been shown to interfere with wound healing by blocking critical host cellular interactions. However, the underlying molecular mechanisms supporting this impediment of wound healing are not completely understood. Here, we …
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Long-Chain Fatty Acids Promote Candida albicans Gut Colonization by Restructuring the Fungal Cell Surface
… acid induced the expression of a variety of adhesins and cell surface components. Finally, I identified <em>SOK1</em> as an oleic acid-induced kinase that dictates cell wall mannan exposure and binding to intestinal mucin under anaerobic conditions. Taken together, these findings indicate …
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SPECIFIC RESIDUES WITHIN PSEUDOMONAS AERUGINOSA AmrZ ARE REQUIRED FOR TRANSCRIPTIONAL REGULATION OF VIRULENCE FACTORS CONTRIBUTING TO INFECTION
… aeruginosa’s virulence factors include motility, adhesins, exotoxins, quorum sensing, biofilm and alginate production. Arguably, its ability to regulate expression of virulence factors and being able to switch to different infectious modes provides a strong advantage for survival. AmrZ is a …
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Characterization of adherence, cytotoxicity and biofilm formation by Gardnerella vaginalis
… searched for sequence homology to known biofilm adhesins using the tBLASTn program. This revealed an open-reading frame encoding a hypothetical protein with significant homology to the staphylococcal Bap protein. Antibody towards a portion of the identified gene product was produced in rabbits by …
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Investigation of Novel Virulence Mechanisms In Candida Albicans
… a broader role of coordinating other surface adhesins based on the data presented. Taken together, this work describes new contributors to pathways known to affect the interactions of <em>C. albicans </em>with the host, which may inform future guided efforts to therapeutically target the …
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ST-1 VISA/DAP-R CA-MRSA INTEGRATED OMICS: A FIRST REPORT OF HYPER-VIRULENCE AND MULTI-DRUG RESISTANT SUPERBUG
… While the Virulome underlined the presence of adhesins, capsular polysaccharides, clumping factors, endotoxins, haemolysins, and leukotoxins including genes encoding the Panton-Valentine leucocidin. The Transcriptome analysis evidenced 147 over-expressed and 53 under-expressed genes in the …
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