Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"adherent invasive escherichia coli"”.
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A Larval Zebrafish (Danio Rerio) Model of Adherent-Invasive Escherichia Coli Infections
… (IBD), including Crohn’s disease and ulcerative colitis, is a broad term for chronic intestinal disorders that severely impact patient morbidity and quality of life. The global prevalence of IBD is rising, with over one million patients affected in the US alone. Adherent-invasive <em>E. coli …
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The invasin IbeA and its role in Adherent-Invasive Escherichia coli (AIEC) pathogenesis
In this study, an Adherent-Invasive Escherichia coli (AIEC) ∆ibeA mutant was constructed and characterized, and its effect on AIEC adhesion and invasion of intestinal epithelial cells evaluated. The role that this outer membrane protein, IbeA, plays in intra-macrophage survival was also assessed. …
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The role of metabolism in the pathogenesis of adherent invasive Escherichia coli (AIEC)
… Recent studies have shown that a new group of Escherichia coli, called Adherent Invasive Escherichia coli (AIEC) are present in the guts of CD patients at a higher frequency than in healthy subjects, suggesting that they may play a role in the initiation and/or maintenance of the inflammation …
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The effects of low-shear modeled microgravity on Streptococcus pneumoniae and adherent-invasive Escherichia coli
… pneumoniae global gene expression and on adherent-invasive Escherichia coli (AIEC) physiology and colonization properties. Habitation in space exposes both humans and microbes to microgravity conditions which are characterized by reductions in fluid shear forces. Areas of low-shear stress …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… selective and significant enrichment of adherent-invasive E. coli (AIEC) pathotype. Notably, in a recent yet unpublished work, we described a new subset of pathogenic Th17 cells (pTh17), selectively enriched in the gut of CD patients that are specifically activated by AIEC strain. …
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Phenotypic characterisation of wild type and mutant strains of adherent invasive Escherichia coli and Shigella, in vitro, ex vivo and in vivo models
… in genetically susceptible individuals.;Adherent-invasive Escherichia coli (AIEC) has been implicated in CD, as has Shigella sonnei due to the shared inflammatory characteristics and susceptible genetic background of Shigellosis and Crohn's disease patients, with both microorganisms …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
… Especially, intestinal enrichment of the adherent-invasive Escherichia coli strain (AIEC), together with a dysregulated activation of the IL-23/pTh17 axis, is a distinctive feature of CD. In this context, current therapies primarily suppress the exaggerated inflammation without directly …
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Evaluation of Intestinal Microbial Diversity and a New Antibiotic Regimen in Crohn's Disease Patients
… (MAP). Other microorganisms such as adherent-invasive Escherichia coli (AIEC) have also been proposed in CD association. To date, only one study investigated both MAP and AIEC simultaneously using peripheral blood but not in affected intestinal tissues. A standardized and effective …
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Identification of bacteria-regulated mechanisms for the pathogenesis of inflammatory bowel diseases (IBD) and development of upconverting nanoparticle (UCNP) luminescence imaging for the monitoring of gut bacteria
… conditions Crohn’s disease (CD) and ulcerative colitis (UC). The environment, the gut microbiota, the genetic make-up and the immune response are believed to contribute to the aetiology of the disease. Non-steroidal anti-inflammatory drugs (NSAIDs) are believed to exacerbate inflammation in …