Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"adherens junctions"”.
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Force-mediated adhesion strengthening in endothelial cells at adherens junctions
… to probe adhesion strengthening at cadherin adherens junctions, using cadherin-coated magnetic beads to simulate neighboring cells and apply force at adherens junctions. 43% of beads exposed to a high force (2.1 nN) detached, compared to 31% of those exposed to a low-to-high force ramp …
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Adherens Junctions and The Actomyosin Network Regulate Organ Growth By Modulating Hippo Pathway Activity In Drosophila
<p>Adherens junctions (AJs) and basolateral modules are important for the establishment and maintenance of apico-basal polarity. Loss of AJs and basolateral module members lead to tumor formation, as well as poor prognosis for metastasis. Recently, in mammalian studies it has been shown that loss …
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Examining the Role and Regulation of Cell-Cell Adhesion in Aggressive Prostate Cancer
… cancer to a metastatic state. While both adherens junctions and desmosomes are involved in establishing and maintaining this adhesion, previous studies of cell-cell adhesion in prostate cancer have focused solely on the role of adherens junctions, leaving the role of desmosomal adhesion …
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The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells
… However, the procedure by which cells establish adherens junctions remains largely unclear. We investigated the dynamics of cell-cell junction formation and the corresponding architecture of the underlying cytoskeleton in cultured human umbilical vein endothelial cells (HUVECs). We show that the …
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The voltage gated calcium channel β2 protein is required in the heart for control of cell proliferation and heart tube integrity
… role of MAGUK proteins is to scaffold cellular junctions and multi-protein complexes. To investigate developmental functions for β2.1, we depleted it in zebrafish using morpholinos. β2.1-depleted embryos developed cardiac edema and lethal cardiac defects. Ventricular cardiomyocytes proliferated …
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The localisation and role of Sidekick at apical vertices in Drosophila epithelial morphogenesis
… localises to vertices at the level of adherens junctions. Using super-resolution microscopy, I investigated the localisation of Sidekick-YFP during germband extension in the early embryo and found that Sidekick-YFP forms string-like structures at cell vertices at the level of adherens …
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Flow-induced mechanotransduction in cell-cell junctions of endothelial cells
… led us to study early shear effects on cell-cell adherens junctions. We found a 30±6% increase in the number of VE-cadherin molecules in the junctions. The strength of interactions of endothelial cells with surfaces coated with recombinant VE-cadherin protein also increased after laminar flow. …
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The dissemination of oncogenic RasV12-transformed cells in the adult Drosophila intestine
… Drosophila E-cad/beta-catenin disassembles at adherens junctions and assembles at invasive protrusions during cell dissemination. Loss of E-cad attenuates dissemination of RasV12-transformed cells by impairing their ability to compromise the ECM. Furthermore, we show that the remodeling of …
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Mechanisms of increased microvascular permeability during acute Rickettsiosis
… by modulating the function of interendothelial adherens junctions. The permeability-inducing effects of these cytokines appear to occur independently of nitric oxide production since inhibition of iNOS does not prevent cytokine-mediated increases in permeability. Additionally we have shown that …
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The spatial organization of the microtubule cytoskeleton and cell divisions promotes tissue morphogenesis
… of actomyosin networks in each cell to adherens junctions, allowing contractile forces to be integrated across the epithelium. However, how actomyosin connections to junctions are maintained during morphogenesis is poorly understood.
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Characterisation of the EDD gene and its role in cancer.
… altered beta-catenin (an integral component of adherens junctions) at cell-cell contacts, which was also observed in the developing blood vessels of Edd null mice. Interestingly, total cellular beta-catenin levels were not affected. Furthermore, EDD depletion resulted in a decrease in expression …
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
… and transwell assays. We also show that EC adherens junctions are disrupted during infection which may provide insight into the role of the endothelium in the pathogenesis of AHF and possibly other viral hemorrhagic fevers (VHFs).
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EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development
… pathway is activated by the ligand Delta at adherens junctions between tip and stalk cells. Despite the centrality of Delta/Notch signaling to angiogenesis, relatively little is known about the mechanism of this signaling event. It has been proposed that the force generated by the Notch bound …
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Contribution of specific amino acids to calcium-dependent dimerization of epithelial cadherin
… Epithelial (E-) cadherin is present at adherens junctions, structures that are important for maintaining tissue integrity. At adherens junctions, cell–cell adhesion complexes are formed as clusters of cadherin dimers through strand-swapped dimerization between two interacting protomers …
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EFFECTS OF RESTRICTIVE DISULFIDE BONDS IN THE VINCULIN TAIL DOMAIN
The C-terminal domain of vinculin, a protein of adherens junctions, is thought to undergo conformational changes upon binding actin or acidic phospholipid. For the present study, cysteine residues were inserted to form disulfide bonds to prevent motion in the arm (residues 1048-1066), strap …
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PROBING CELLULAR MECHANO-SENSITIVITY USING BIOMEMBRANE-MIMICKING CELL SUBSTRATES OF ADJUSTABLE STIFFNESS
… N-cadherin linkers underneath cellular adherens junctions. In addition, properties of individual and clustered N-cadherins are examined in the polymer-tethered bilayer system in the absence of plated cells.
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The Impact of pH on the Structure and Function of Neural Cadherin
… (N-) cadherin is a transmembrane protein within adherens junctions that mediates cell-cell adhesion. It has 5 modular extracellular domains (EC1-EC5) that bind 3 calcium ions between each of the modules. Calcium binding is required for dimerization. N-cadherin is involved in diverse processes …
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Nickel Reduces Calcium Dependent Dimerization In Neural Cadherin
… are the primary transmembrane component in adherens junctions, structures that link the actin cytoskeleton in adjacent cells within solid tissues including neurological synapses, epithelium and endothelium. Cell-cell adhesion by cadherins requires the binding of calcium ions to specific …
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Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation
… on Pins recruitment, through disrupting adherens junctions, actomyosin contractility, laser-induced tissue isolation, and, finally, by disrupting mesoderm invagination. Overall, the results show how mechanical forces are integrated across an embryo to control cell division via a novel …
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
… between different cells, through cadherin-based adherens junctions (AJs). Importantly, both types of cell adhesions act as sensitive force sensors, which change their size and shape in response to external mechanical signals. Traditionally, the correlation between adhesion linker assembly and …
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