Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"adherens junction"”.
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
… and transwell assays. We also show that EC adherens junctions are disrupted during infection which may provide insight into the role of the endothelium in the pathogenesis of AHF and possibly other viral hemorrhagic fevers (VHFs).
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
An insufficiency in omega-3 fatty acids has been linked to a wide variety of health concerns including Alzheimer’s disease, CHD, sub-optimal fetal development and male infertility. The long chain omega-3 docosahexaenoic acid (DHA) and omega-6 arachidonic acid (ARA) are highly unsaturated fatty …
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
… of F-actin. Induced F-actin colocalized with the adherens junction proteins α-catenin, β-catenin and p120catenin in HaCaT-Ras cells, suggesting that stable adherens junctions were mediating the increase in cell-cell adhesion. Additionally, Dasatinib treatment significantly inhibited cell migration …
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Systemic Leptin Modulates the Expression of E-cadherin, β-catenin in the Ovary of Dietary-Induced Obese Infertile Rats
… complex, which is a structural constituent of adherens junction, is expressed in the rat ovary during folliculogenesis. We hypothesized that systemic leptin modulates the expression of E-cadherin and β-catenin in dietary-induced obese infertile rats to reverse infertility. Female Sprague-Dawley …
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Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight junction complexes
Intercellular adherens junction (AJ) and tight junction (TJ) proteins (e.g. VE-Cadherin, occludin, ZO-1, claudin-5) jointly consolidate the apical surface of adjacent brain microvascular endothelial cells (BBMvEC’s) creating the blood-brain barrier (BBB), a critical regulator of CNS homeostasis. …
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NS1 of H5N1 Interacts with SAP-97 in a PDZ-dependent Manner to Disrupt Epithelial Barrier Integrity
… binds synapse-associated protein-97 (SAP-97), an adherens junction protein, in a PDZ motif-dependent manner. In H5N1 infected tissues, the SAP-97 distribution is reorganized. Functionally, the interaction of NS1 and SAP-97 results in the loss of epithelial barrier function. This mechanism helps to …
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Identification of echinus and characterization of its role in Drosophila eye development
… of DE-cadherin and Enabled accumulation in adherens junctions of retinal epithelial cells. Genetic interactions were observed between echinus and the genes wingless, enabled and expanded. An immunofluorescence assay in Drosophila S2 cell cultured demonstrated that Echinus localizes to …
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A study of keratinocyte differentiation and adhesion in vitro
… kinases at calcium-induced cadherin-mediated adherens junctions. The ubiquitously expressed members of this family, c-Src, Fyn and c-Yes were localised to the cadherin-mediated adhesions formed in response to high extracellular calcium. Treating adherent keratinocytes maintained in low …
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IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling
… promoted an enrichment of actin cytoskeletal and adherens junction-related proteins including the molecular scaffold IQGAP1 and the small GTPase Rac1. Subsequent investigation revealed that the association between Rac1 and IQGAP1 increased with GnRH receptor stimulation and that GnRH increased …
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Mechanisms of increased microvascular permeability during acute Rickettsiosis
… by modulating the function of interendothelial adherens junctions. The permeability-inducing effects of these cytokines appear to occur independently of nitric oxide production since inhibition of iNOS does not prevent cytokine-mediated increases in permeability. Additionally we have shown that …
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Dissecting the Functions of Classical Cadherins in Skin
… of cadherin dependent and independent roles of adherens junction components in the epidermis. The ability to clearly dissociate cadherin and catenin functions and to identify regulatory processes governing their interaction should prove useful in the context of both development and disease.</p>
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The role of PTPRF and PTPRK in regulating cell adhesion
… by selectively dephosphorylating several junction regulators, including Afadin, which is recruited via its D2 domain. Using biochemical approaches, I investigated the specificity of this interaction and found that the same region of Afadin had previously been shown to interact with …
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Effect of the Insulin-like Growth Factor (IGF) Axis on the Transport Properties of Endothelial and Epithelial Cells In Vitro
… autocrine production of IGF-I modulates tight junction permeability and (2) demonstrate the ability of IGFBPs to regulate IGF-I delivery across cell layers. To meet the first objective, parental and IGF-I secreting bovine mammary epithelial cells were tested for cell layer permeability, tight …
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Regulation of Cell Adhesion By The Ferm Proteins, Ptpn14 and Merlin
… been shown to localize and possibly regulate adherens junction (AJ) functions. This work sought to determine if PTPN14 is required for the establishment of epithelial adhesion and polarity. Using mammalian epithelial cells as a model to test these hypotheses, we down-regulated the tyrosine …
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Rapid Functional Dissection of Genetic Networks Via RNAi In Mouse Embryos
… of mutant clones in a mosaic tissue. Taking the adherens junction protein α-catenin as a paradigm, this approach was used to uncover new insights into its role as a widely expressed tumor suppressor and regulator of epithelial integrity. Using simultaneous gene depletion I uncovered physiological …
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Role of Sodium Arsenite in Atherogenesis
… barrier is maintained by proteins of the adherens junction (AJ) such as vascular endothelial cadherin (VE-cadherin) and β-catenin, and their association with the actin cytoskeleton. Treatment of HAECs with As(III) resulted in reorganization of actin filaments into stress fibers and …
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Role of Sodium Arsenite in Atherogenesis
… barrier is maintained by proteins of the adherens junction (AJ) such as vascular endothelial cadherin (VE-cadherin) and β-catenin, and their association with the actin cytoskeleton. Treatment of HAECs with As(III) resulted in reorganization of actin filaments into stress fibers and …
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Germ lineage specification from a pluripotent primitive ectoderm-like substrate: a role for cell-cell contacts.
… a number of protein targets including the adherens junction component E-cadherin. Addition of DAPT to differentiating EPL cells has the opposite effect to SSP, with an increase in ectodermal differentiation at the expense of medoderm. It is proposed that DAPT is acting by preventing …
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Genetic Approaches to Study Tissue Morphogenesis in Drosophila
… Sqh1P predominantly localizes in the adherens junction in imaginal disc cells, whereas Sqh2P locates to the apical domain. Sqh1P and Sqh2P also show distinct patterns of expression in embryos. Sqh1P is expressed nearly ubiquitously and outlines cells consistent with a junctional …
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Etablierung und Charakterisierung eines Csrp2-defizienten Mäusestammes
… disk with increased expression of the adherens junction proteins (beta-catenin and N-RAP) were found. Furthermore, enlarged heart fibers, slightly dilated thinner left ventricle and a diminished heart activity were detected. Together these changes in the heart demonstrate that the …
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