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Showing 1 to 8 of 8 for “"adenylyl cyclases"”.
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Calcium-Stimulated Adenylyl Cyclases are Critical Modulators of Fear Learning and Experience-Dependent Plasticity
… a role of the Ca<super>2+</super>-stimulated adenylyl cyclases: AC), AC1 and AC8, in modulating fear memory. Ca<super>2+</super>-stimulated AC activity couples neuronal activity and intracellular Ca<super>2+</super> increases to the production of cAMP, and therefore, can very tightly regulate …
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THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES
Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes. Adenylyl cyclases are diverse in their structure and biochemistry, and have been …
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Allosteric Determinants of Guanine Nucleotide Binding Proteins and Methods to Crystallize the Cytosolic Domains of Adenylyl Cyclase
The cytosolic domains of mammalian adenylyl cyclases, termed C1 and C2, are responsible for catalytic activity and most regulatory properties. Crystal structures of the soluble catalytic core of adenylyl cyclase bound to activators Gsa and forskolin were previously determined. However, structural …
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HAMP Domain and Signaling Mechanism of the Aer Protein
… chemoreceptors, histidine kinases, adenylyl cyclases, and other sensory proteins in all three domains of life. The linker region is re-designated as a “HAMP” domain that might mediate sensing, propagation of transmembrane signals, or protein-protein interactions.</p> <p>The Aer HAMP …
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Structural Characterisation of the Catalytic Core of the Class III Adenylyl Cyclase Rv0386 from Mycobacterium tuberculosis
… Interesse an mycobakteriellen Adenylat-Zyklasen (Adenylyl Cyclases, ACs), die den universellen second messenger cAMP herstellen, ist groß, insbesondere weil regulatorische Prozesse, an denen cAMP beteiligt ist, lebenswichtig für dieses Pathogen zu sein scheinen. Man findet erhöhte cAMP …
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The effect of guanine nucleotides on glucagon-sensitive adenylate cyclase in the rat heart
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… machinery (i.e. Orai1/STIM1), a Ca2+-activated adenylyl cyclase (ADCY8), PKA and the A-kinase anchoring protein (AKAP79). Based on our findings, we suggest that inhibiting the actions of PDE1C may represent a valid novel therapeutic approach to decrease the burden associated with unregulated …
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
… were observed suggesting that both the adenylyl cyclase and phosphodiesterase activities remained unchanged in the PDE inhibitor-resistant strain. In support of this, the sequencing of TbrPDEB1 and TbrPDEB2 in both strains, while uncovering the loss of heterozygosity in the R0.8 line, …