Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"adenylate cyclase"”.
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Pituitary adenylate cyclase-activating polypeptide regulates excessive alcohol consumption
… of a peptide antagonist for the pituitary adenylate cyclase-activating polypeptide receptor 1 (PAC1), the cognate receptor for the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP), blocks excessive alcohol drinking as well as motivation to drink. On the other hand, …
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Pituitary Adenylate Cyclase -Activating Peptide Signaling in the Mouse Circadian Clock
… a variety of sources suggest a role of pituitary adenylate cyclase-activating peptide (PACAP) in light/glutamate-induced phase resetting of the circadian clock, yet the particulars of this role remain controversial. Mice generated by Lee Eiden and colleagues that do not express PACAP were examined …
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Characterization and localization of adenylate cyclase during development of Dictyostelium discoideum
… differentiation. Biochemical characterization of adenylate cyclase, the cyclic AMP synthetic enzyme, was accomplished using a sensitive radioimmunoassay. The enzyme was found to be pellet-bound. The non-ionic detergents, Triton X-100 and Lubrol PX, were not effective for solubilizing this …
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Studies on the Interaction of Adenylate Cyclase With Animal Cell Plasma Membranes
Made available in DSpace on 2014-12-14T04:27:41Z (GMT). No. of bitstreams: 1 7803983.pdf: 8352676 bytes, checksum: 3cd3a1a81163c7c8339507925fcfe2a3 (MD5) Previous issue date: 1977
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Partial Purification and Characterization of the Calmodulin Sensitive Bovine Brain Adenylate Cyclase
The calmodulin (CaM) sensitive bovine brain adenylate cyclase was resolved, in a solubilized form, from calmodulin and a CaM-insensitive form of the enzyme. Affi-Gel Blue chromatography, incorporating EGTA-containing buffer washes and elution with 8 mM ATP/l M KCl, produced partially purified …
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EFFECT OF ALCOHOL ON THE REGULATION OF ADENYLATE CYCLASE ACTIVITY IN MOUSE BRAIN.
EFFECT OF ALCOHOL ON THE REGULATION OF ADENYLATE CYCLASE ACTIVITY IN MOUSE BRAIN.
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The Solubilization and Partial Purification of Adenylate Cyclase From Rat Liver Plasma Membranes
Made available in DSpace on 2014-12-14T04:27:43Z (GMT). No. of bitstreams: 1 7804138.pdf: 5451091 bytes, checksum: 7f0ae2a06a3c2cd130512e70d3f5ef4b (MD5) Previous issue date: 1977
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The effect of guanine nucleotides on glucagon-sensitive adenylate cyclase in the rat heart
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Studies on Adenylate Cyclase in Normal and Rous Sarcoma Virus Transformed Chicken Embryo Fibroblasts
Made available in DSpace on 2014-12-14T04:27:47Z (GMT). No. of bitstreams: 1 7915352.pdf: 8063286 bytes, checksum: 7ce27a88929613339fbfd3db64581ec7 (MD5) Previous issue date: 1979
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Structural Characterization of the Switch domain regions of Schistosoma mansoni druggable Adenylate cyclase-stimulating Gα-protein
Among the neglected tropical diseases (NTDs), schistosomiasis, a common human parasitic disease; continues to rank high as one of the major causes of morbidity and mortality among the labour forces in known endemic regions. Recently, the socio-economic impact of Schistosoma infections have been …
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Micro-analysis of adenylate cyclase and cyclic AMP-dependent protein kinase activities in human mammary tumors
… was used to elucidate the enzyme profiles of adenylate cyclase and cAMP-dependent protein kinase within a series of malignant and benign human mammary tumors. The methods allow for determination of enzyme activity in histologically-confirmed neoplastic areas within individual tumors which …
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Adrenergic-cholinergic interactions in the heart
… agonist, forskolin, a direct activator of adenylate cyclase, IBMX, a phosphodiesterase inhibitor, and phenylephrine, an a-adrenoceptor agonist. While the inhibitory effect of carbacholon the isoproterenol-stimulated cAMP generation is believed to contribute to the negative inotropic effect …
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Regulation of duodenal mucosal bicarbonate secretion
… on the duodenal enterocytes, activating adenylate cyclase and protein kinase A in sequence to initiate bicarbonate secretion. In addition, there is good evidence that the inositol phospholipid and protein kinase C cascade is also involved, possibly to a lesser extent, since …
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Modeling and Mapping Addiction in the Zebrafish, Danio rerio
… DRD1 stimulate the neuron by upregulating adenylate cyclase activity, while DRD2 inhibits neurons by blocking or down-regulating adenylate cyclase. Though greatly conserved, the reward system can be hijacked by chemicals that trigger the release of dopamine. Drugs of abuse, like …
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Defining Topologically Oriented Transmembrane Helix Contacts in Integral Membrane Protein EmrE by a Modified Two-Hybrid Approach
… is presented an application of the Bacterial Adenylate Cyclase Two-Hybrid (BACTH) method to study oligomerization in membrane proteins applied to model integral membrane multidrug transporter EmrE. The system was unable to observe dimerization between full length monomers of EmrE, likely due …
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INFLUENCE OF BIOGENIC AMINES ON BOVINE LUTEAL STEROIDOGENESIS
… receptor, which may not be associated with adenylate cyclase. Analysis of bovine luteal tissue using high performance liquid chromatography demonstrated the presence of serotonin, and showed that the concentration of serotonin varied with the stage of luteal development. Administration of …
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Phosphorylation sites on specific neuronal proteins can control the mode of synaptic vesicle exocytosis and thereby regulate synaptic transmission
… in regulating the modes was investigated. Adenylate cyclase activation by forksolin inhibits the release of the RP but switches all the RRP vesicles to KR when evoked by 4AP5C. Adenylate cyclase inhibition by 9-Cyclopentyl-Adenine (9-Cp-Ade) has no effect on GLU release or exocytotic mode. …
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