Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"adenoviral gene transfer"”.
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Multivariate analysis of transcriptional changes following restoration of SERCA2a levels in failing rat hearts
We have identified the genes responsible for SERCA2a-induced reversal of heart failure, the leading cause of morbidity and mortality in the United States and developed countries. We have previously shown that restoration of a key enzyme that controls intracellular Ca2+ handling, the Sarcoplasmic …
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Molecular imaging of gene transduction in cardiac transplantation
… of experiments aimed at designing a model of gene transfer to the transplanted heart. The use of viral vector-based gene therapy to target pathological processes following cardiac transplantation faces many challenges including the potential effects of the virus on the host as well as the need …
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Regulation of acid-stimulated H+ secretion by Pyk2 and MAPK signaling pathways in the outer medullary collecting duct
… ERK1/2 phosphorylation. Furthermore, we used adenoviral-gene transfer of AdCRNK, a dominant-interfering truncated Pyk2 construct, to block Pyk2 phosphorylation at Tyr402 as well as the p38-specific inhibitor, SB203580. The pH-sensitive fluorescent probe BCECF-AM was used to assay H+ …
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Cytokine gene transfer by adenoviral vectors as a novel therapeutic option for hepatitis B virus infection
… of my thesis was to establish a liver directed gene transfer and to characterize the effect of local expression of interferon on HBV replication. Two sets of adenoviral vectors were established: the first using the CMV promoter (PCMV) (AdmIFNg and AdmIFNb) and the second using a bidirectional …
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X-Box Binding Protein-1 is Important in Maintenance of Endothelial Integrity and Migration
… Similarly to HDACS, overexpression of XBPlu by adenoviral gene transfer increased Akt phosphorylation at serine 473 and haem oxygenase 1 gene transcription, which showed a protective role in hydrogen peroxide-induced apoptosis of endothelial cells. Co-immunoprecipitation assays demonstrated that …
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Morphological characterization of liver fibrogenesis in animal models with genetically modulated TGF-beta signal transduction
… is impaired. In a healthy liver, synthesis (fibrogenesis) and degradation (fibrolysis) of matrix tissue are in balance. Fibrosis occurs when scar tissue is generated in excess and faster than it is degraded and removed from the liver. TGF-beta is known to play a central role in regulation of the …
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Adenovirus-mediated gene transfer of FK506-binding proteins FKBP12.6 and FKBP12 in failing and non-failing rabbit ventricular myocytes
… des RyR2 durch FKBP12.6 könnte an der Pathogenese von Herzinsuffizienz beteiligt sein. Deshalb soll in dieser Arbeit auch die Interaktion von RyR2 mit FKBP12.6 an einem Kaninchenherzinsuffizienz-Model untersucht werden. Ziel ist es zu prüfen, ob FKBP12.6 als neues Target-Molekül" zur …