Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"adenosine signaling"”.
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The Role of Adenosine Signaling In Mature Erythrocytes and Erythroid Progenitors
<p>Adenosine is a ubiquitous nucleoside in almost all the cells throughout our bodies. It is highly induced particularly under hypoxia or energy depletion conditions. Adenosine functions as a critical ligand, after binding to membrane-associated adenosine receptors, adenosine initiates a downstream …
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Structural and Functional Studies of Nucleoside Transporters
… route for nucleoside-like drugs and regulates adenosine signaling. The eukaryotic cell possesses two evolutionarily unrelated protein families of nucleoside transporters, the concentrative nucleoside transporters and the equilibrative nucleoside transporters. We aimed to elucidate their …
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Design of Biomaterials toward Endogenous Skeletal Tissue Repair
… to promote skeletal tissue health. </p><p>Adenosine, a nucleoside ubiquitously present in the human body, is a potent pro-healing small molecule. A surge in adenosine secretion ensuing from injury is integral to the natural repair mechanisms. There is growing evidence that harnessing …
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Molecular Mechanisms Involved in Escherichia coli K1 and Haemophilus influenzae Type a Blood-Brain Barrier Impairment
… study demonstrated the correlation between the adenosine signaling pathway and BBB breakdown, highlighting the modulatory role of A2A and A2B adenosine receptors. In conclusion, association of an antibiotic therapy with a drug able to block the VEGFR-1 on pericytes could represent a novel …
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Inhibition of adenosinergic signaling in the tumor immune environment: the effect of combination CD73 blockade and oHSV therapy on solid tumors
… advantage of immunosuppressive extracellular adenosine (eADO) signaling as a means of escaping host anti-tumor immune responses. Transcriptomic analysis of patient tumors pre- and post-virotherapy with CAN-3110 revealed increased expression of the adenosine receptor gene <em>ADORA2B </em>after …
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Elevated Cochlear Adenosine Causes Hearing Loss Via Adora2B Signaling
… metabolic energy currency. Patients who lack adenosine deaminase (ADA), the enzyme that irreversibly metabolizes adenosine, have high levels of adenosine that yield severe health problems, including HL; however, the pathogenic mechanisms behind HL and adenosine remain elusive. Our lab has …
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Role and Regulation of Sphingosine 1-Phosphate In Erythrocyte
<p>Sphingosine 1-phosphate (S1P) is a bioactive signaling sphingolipid produced in every mammalian cell. It plays a variety of important roles both in and outside of cells. S1P is highly enriched in mature erythrocytes because of the high enzymatic activity of the S1P-generating enzyme Sphingosine …