Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"adenosine monophosphate (AMP)"”.
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Studies on the mechanism of action of thyroid hormones
Inosine monophosphate (IMP) is a precursor of the two purine nucleotides, adenosine monophosphate (AMP) and guanosine monophosphate (GMP)e through DEAE-Scphacex, and the reaction IMP~ XMP is catalyzed by: IMP dehydrogenase which was purified in a manner similar to adenylosuccinate synthetase. …
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Direct Measurements of the Effects of Cyclic Adenosine Monophosphate, and Related Compounds, on Membrane Conductances, Intracellular Calcium and Ph in Gastropod Neurons (cyclic-Amp)
… effects of intracellular injections of cyclic adenosine monophosphate (AMP) and related compounds were examined in identifiable gastropod neurons. Injecting cyclic AMP (or cyclic GMP) in amounts which should have elevated the internal concentration from 0.1-7.6 mM (mean = 3.3 mM) resulted in …
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In Pursuit of a Molecular Fountain of Youth: The Identification and Characterization of Lifespan Regulators in Drosophila
… to humans. Next, we identified the two key adenosine monophosphate (AMP) biosynthetic pathways as regulators of Drosophila longevity. We found that heterozygous mutation of anabolic components of the de novo as well as the salvage AMP biosynthesis pathways extend lifespan. These pathway …
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The Effect of AICAR Treatment on Sarcoplasmic Reticulum Function and Possible Links to Skeletal Muscle Fatigue
… and slowed relaxation. During exercise, adenosine 5'-triphosphate (ATP) is the energy currency that is used to support force production. As a result of ATP hydrolysis and re-synthesis, adenosine diphosphate (ADP) and adenosine monophosphate (AMP) levels rise. AMP kinase (AMPK) is an …
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ISPH fusion proteins, ISPH inhibition, and bisphosphonate mechanism of action
… cluster. Additionally, a virtual screening campaign was carried out by collaborators at the University of California – San Diego, and enzymatic testing of the top hits identified a spirocyclic barbituric acid that exhibited a Ki of ~ 500 nM against Pseudomonas aeruginosa IspH. Synthesis of …
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Protein quality and distribution determines anabolic signaling, cellular energetics, and body composition
… was associated with increases in activity of AMP kinase, a key cellular energy sensor. This research shows that the Leu density of dietary protein determines anabolic signaling, thereby affecting cellular energetics and body composition.