Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"adenosine a2b"”.
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Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function
<p>Adenosine A<sub>2B</sub> receptor (A<sub>2B</sub>R) appear to contribute to chronic inflammation. This receptor is highly expressed in macrophages and cardiac fibroblasts, cells which play key roles in inflammation and healing following myocardial infarction (MI). A<sub>2B</sub>R have been shown …
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LATE PROTECTIVE EFFECTS OF NETRIN-1 AND ADENOSINE A2B RECEPTOR ACTIVATION IN THE MURINE ACETAMINOPHEN HEPATOTOXICITY MODEL
… to explore the role of netrin-1 and its receptor adenosine A2B in APAP hepatotoxicity. In the first study, we explored the mechanisms behind the mice sub-strain susceptibility to APAP toxicity. We demonstrated that C57BL/6N mice were more susceptible to APAP-induced hepatotoxicity than C57BL/6J …
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Systemic inflammatory regulation of blood-brain barrier inflammation
… selective protein kinase A-activator and adenosine A2B receptor agonist could recreate these effects. However, an A2B receptor antagonist did not block the imiquimod-mediated effects. The endothelial cells of the blood-brain barrier are an essential interface between the systemic …
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Elevated Cochlear Adenosine Causes Hearing Loss Via Adora2B Signaling
… metabolic energy currency. Patients who lack adenosine deaminase (ADA), the enzyme that irreversibly metabolizes adenosine, have high levels of adenosine that yield severe health problems, including HL; however, the pathogenic mechanisms behind HL and adenosine remain elusive. Our lab has …