Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"adenosine A1 receptor"”.
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Modulation as an Acidosis-Evoked Current by A1 Adenosine Receptors in the CA1 Region of the Mouse Hippocampus
… manner, independent of glutamate receptor activation. Adenosine is released during periods of metabolic stress and exerts a neuroprotective role mediated by adenosine A1 receptor stimulation. The purpose of this project was to study the effect of adenosine A1 receptor stimulation …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… similar properties to primary cardiomyocytes. Adenosine receptors are well known mediators of cardioprotection and trigger effectors such as the mitochondrial KATP channel – however, the role of the mitochondrial BKCa channel in adenosine receptor-mediated cardioprotection has not been …
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Accelerated simulations and computer-aided drug design of membrane proteins
… dependence of GPCR-membrane interactions on the receptor activation state and retrospective docking of known positive allosteric modulators (PAMs) to GaMD simulation-derived structural ensembles of the adenosine A1 receptor (A1AR), respectively. Finally, in Chapter 5, I apply LiGaMD to understand …
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The prevalence of hyponatremia and effects of aminophylline on serum sodium ions in premature neonates admitted to Neonatal Intensive Care Unit, at the University Teaching Hospital, Lusaka, Zambia
… have demonstrated that aminophylline, an adenosine A1 receptor antagonist, has a diuretic effect and has been implicated in lowering serum sodium levels in premature neonates. However these studies did not address the need for sodium supplementation for neonates receiving aminophylline. …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… release several endogenous mediators including adenosine, bradykinin or nitric oxide (NO), that may trigger a signaling cascade leading to protection against I/R injury. Our results show that sildenafil, at a clinically relevant dose, induced powerful acute and delayed cardioprotection against …
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Evaluation of indigenous medicinal plants with potential antidepressant effects
… using the serotonin transporter (SERT) and the adenosine A1R & A2AR radioligand binding assays. The systematic review of twenty eligible ethnobotanical publications identified 186 indigenous South African plants from 63 families used traditionally to manage depression and related ailments. Only …
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The electrophysiology of the atrioventricular node in normal and failing rabbit hearts
… for the observed abnormal conduction delay. Adenosine is known to have profound effects on AV nodal conduction and the possibility of tonic excess of adenosine in LVD was explored as a possible mechanism for the prolonged conduction delay. Using an exogenously applied adenosine A1 receptor …
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Exploring the molecular signatures of the ligand-receptor-Gi/o protein interactions of adenosine A1 and A3 receptors
Human adenosine A1 receptor (hA1R) and adenosine A3 receptors (hA3R) are two closely related class A Gi/o-coupled receptors. Both of them represented valuable therapeutic targets and various types of ligands have been developed for regulating their activities. hA1R has important implications in …
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Engineering the angiotensin II type 1 receptor for structural studies
G protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that perform transmembrane signal transduction. Due to their pivotal role in a wide range of essential physiological functions GPCRs represent a high proportion of all drug targets. High resolution X-ray structures of …