Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 450 for “"adenosine"”.
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
… result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through interaction with four G-protein coupled adenosine receptors: A1R, A2AR, A2BR, and A3R. However, …
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Synthesis towards synthetic adenosine receptor
Adenosine is a biologically important molecule as it acts as local modulator with cytoprotective function in the body. Adenosine accumulates in the extracellular space in response to metabolic stress and cell damage, and elevations in extracellular adenosine level are found in conditions like …
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Molecular recognition of adenosine derivatives
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Extracellular adenosine as a novel neuroimmune modulator
Adenosine is a pleotropic purine nucleoside with actions ranging from neurotransmission to immunomodulation. Pathologic processes that trigger cellular stress and damage also cause significant increases in local and systemic concentrations of adenosine. Coinciding with elevation in adenosine is an …
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Elevated Cochlear Adenosine Causes Hearing Loss Via Adora2B Signaling
… metabolic energy currency. Patients who lack adenosine deaminase (ADA), the enzyme that irreversibly metabolizes adenosine, have high levels of adenosine that yield severe health problems, including HL; however, the pathogenic mechanisms behind HL and adenosine remain elusive. Our lab has …
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Adenosine triphosphate is an allosteric inhibitor of coxsackievirus B3 3Dpol
Picornaviruses pose a significant threat to human and animal health, but at present there are no drugs to prevent or treat picornaviral infections. However, intensive study of the picornaviral lifecycle has revealed several promising pharmacological targets, including the RNA-dependent RNA …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
<p> <p>Adenosine is a purinergic signaling molecule that regulates various aspects of inflammation and has been implicated in the pathogenesis of chronic lung diseases. Previous studies have demonstrated that adenosine up-regulates IL-6 production through the engagement of the A<sub>2B</sub> …
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Adenosine receptors in cutaneous thermal hyperemia and active vasodilation in humans
… it remains unclear as to the source of NO. Adenosine receptors induce vasodilation in many human tissues and may work, in part, through NO. As these receptors are also known to be located in the cutaneous vasculature, the studies contained in this thesis were designed to investigate a …
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The Role of Adenosine Signaling In Mature Erythrocytes and Erythroid Progenitors
<p>Adenosine is a ubiquitous nucleoside in almost all the cells throughout our bodies. It is highly induced particularly under hypoxia or energy depletion conditions. Adenosine functions as a critical ligand, after binding to membrane-associated adenosine receptors, adenosine initiates a downstream …
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Identification of an extracellular adenosine 5'-triphosphate receptor in Arabidopsis thaliana
… OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Adenosine 5'-triphosphate (ATP) is a well-known energy currency in all organisms. However, ATP also acts as a signaling molecule when it is secreted outside the cell. The long-term goal of my research is to understand the molecular mechanism of …
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Synthesis and Biological Evaluation of Modified Adenosine and Thymidine Nucleoside Analogues
… beschreven we de synthese van gemodificeerde adenosine en thymidine analogen (zie Figuur 1). Deze verbindingen werden als moleculaire probes gebruikt voor de biologische evaluatie van adenosine-receptoren (ARn, Deel II, Hoofdstuk 3-6), die behoren tot de G-proteïne gekoppelde receptor (GPCR) …
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Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function
<p>Adenosine A<sub>2B</sub> receptor (A<sub>2B</sub>R) appear to contribute to chronic inflammation. This receptor is highly expressed in macrophages and cardiac fibroblasts, cells which play key roles in inflammation and healing following myocardial infarction (MI). A<sub>2B</sub>R have been shown …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
… has shown that extracellular accumulation of adenosine and subsequent activation of the adenosine 2B (ADORA2B) receptor promotes immune cell invasion, airspace destruction, and fibrosis in chronic lung disease. Additionally, alternatively activated alveolar macrophages (AAMs) expressing …
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