Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"adenomatous polyposis coli (APC)"”.
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
Adenomatous polyposis coli (APC) is a tumor suppressor gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
Adenomatous polyposis coli (APC) is a tumor suppressor gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. …
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Identification of binding protein with kinesin18B
… also associate with the tumor suppressor protein adenomatous polyposis coli(APC) and p150glued, a component of the dynactin complex. EB1 interacts with kinesin18B and has been localized to clusters near the distal ends of microtubules. Kinesin18B has been shown to move along microtubules and has …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
<p>Inactivation of the adenomatous polyposis coli (APC) tumor suppressor is</p> <p>common genetic event across many cancers and serves a critical initiating</p> <p>event in the majority of sporadic colorectal cancers (CRC). The WNT/APC</p> <p>pathway remains an elusive target for cancer, prompting …
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Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
… cancers are associated with a mutation in the Adenomatous polyposis coli (APC) tumor suppressor gene. We study the intracellular functions of normal APC and how loss of APC function leads to the formation of precancerous polyps in the intestines of mice and humans. The studies presented here …
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Validation-based insertional mutagenesis (VBIM) technology identifies adenomatous polypossis coli (APC) like protein (ALP) as a novel negative regulator of NF-κB
… strategy, our lab has identified the novel adenomatous polyposis coli (APC) like protein (ALP) gene as a negative regulator of NF-κB. Preliminary studies from our lab demonstrated that overexpression of ALP led to decreased NF-κB activity by κB reporter assay and electrophoresis mobility gel …
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Novel interactions and functions of the Adenomatous polyposis coli protein
Mutations of the Adenomatous polyposis coli (APC) gene are a frequent and early event in the development of sporadic colorectal cancer and also form the genetic basis of familial adenomatous polyposis. APC is an established regulator of the cytoskeleton, however, the tumour suppressive function of …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… are driven by loss-of-function mutations in the Adenomatous Polyposis Coli (APC) tumour suppressor gene, and are largely refractory to current cancer immunotherapies. As presented in this thesis, examination of cancer gene expression profiles from CRC patients in large, publicly available online …
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An immunohistochemical study of beta-catenin in HNPCC colon tumours
Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane. If APC/beta-catenin is disrupted, beta-catenin transfers into the nucleus, where it functions as a transcriptional activator, causing unregulated …
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The role of APC in cellular and tissue organisation in intestinal tumorigenesis
The tumour suppressor adenomatous polyposis coli (APC) is a multifunctional protein regulating a diverse array of effector pathways essential for cellular homeostasis. In most sporadic colon cancers, truncating mutations in APC lead to the loss of the Wnt pathway and microtubule regulatory domains. …
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Regulation of MINK1 by APC, PKA and MARK3/4 and consequences for epithelial cell biology
… colorectal cancers the tumour suppressor gene adenomatous polyposis coli (APC) is mutated. The APC protein is closely linked to epithelial tissue homeostasis, it is a scaffolding protein in Wnt signalling and is important for cytoskeletal regulation. Misshapen/NIK-related kinase 1 (MINK1) was …
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Spatiotemporal dynamics of cell division in intestinal homeostasis
… are altered in tissue carrying mutations in Adenomatous polyposis coli (Apc), highlighting its importance for normal tissue homeostasis.<br/><br/>Secondly, I aimed to understand the dynamics of cell-cycle commitment in intestinal crypt compartments by investigating the DNA Replication …
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The biomechanical properties of epithelial cells and tissue in two and three dimensions
… cancer, by the expression of a truncated Adenomatous polyposis coli (APC) protein: N-APC. N-APC is present in most cases of colorectal cancer and provides a useful tool to study the early changes in colorectal cancer. MDCK cells form spherical cysts up to 100 μm in diameter with a hollow …
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Wnt Signaling in Growth Cone Mediated Neurite Outgrowth from Spiral Ganglion Neurons in the Adult Mouse
Profound sensorineural hearing loss affects nearly 700,000 people in the United States and cannot be treated with hearing aids. Many listeners receive cochlear implants that can restore hearing by directly stimulating spiral ganglion neurons with electrodes implanted in the inner ear. However, the …
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Identifying Protein Kinase Tbk1 As A Novel Inhibitor of Intestinal Tumorigenesis
… formation in mice carrying a mutation in the <em>Apc</em> gene, a tumor-suppressor gene commonly mutated in the early stages of colon cancer development. Interestingly, <em>Tbk1</em> expression is important for the crosstalk of IECs with intraepithelial lymphocytes that maintain the expression of …