Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"adenomatous polyposis coli"”.
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Novel interactions and functions of the Adenomatous polyposis coli protein
Mutations of the Adenomatous polyposis coli (APC) gene are a frequent and early event in the development of sporadic colorectal cancer and also form the genetic basis of familial adenomatous polyposis. APC is an established regulator of the cytoskeleton, however, the tumour suppressive function of …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
Adenomatous polyposis coli (APC) is a tumor suppressor gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
Adenomatous polyposis coli (APC) is a tumor suppressor gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. …
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Identification of binding protein with kinesin18B
… also associate with the tumor suppressor protein adenomatous polyposis coli(APC) and p150glued, a component of the dynactin complex. EB1 interacts with kinesin18B and has been localized to clusters near the distal ends of microtubules. Kinesin18B has been shown to move along microtubules and has …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
<p>Inactivation of the adenomatous polyposis coli (APC) tumor suppressor is</p> <p>common genetic event across many cancers and serves a critical initiating</p> <p>event in the majority of sporadic colorectal cancers (CRC). The WNT/APC</p> <p>pathway remains an elusive target for cancer, prompting …
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Investigation of the role of chromosome missegregation in embryo development and in tumorigenesis
… the protein most often altered in colon cancers, Adenomatous Polyposis Coli (AdPC) (Kinzler and Vogelstein 1996), is modified by members of the spindle assembly checkpoint and that a truncating mutation of the AdPC protein leads directly to aneuploidy in mouse cells. Although genetic disruption of …
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Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
… cancers are associated with a mutation in the Adenomatous polyposis coli (APC) tumor suppressor gene. We study the intracellular functions of normal APC and how loss of APC function leads to the formation of precancerous polyps in the intestines of mice and humans. The studies presented here …
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Validation-based insertional mutagenesis (VBIM) technology identifies adenomatous polypossis coli (APC) like protein (ALP) as a novel negative regulator of NF-κB
… strategy, our lab has identified the novel adenomatous polyposis coli (APC) like protein (ALP) gene as a negative regulator of NF-κB. Preliminary studies from our lab demonstrated that overexpression of ALP led to decreased NF-κB activity by κB reporter assay and electrophoresis mobility gel …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… are driven by loss-of-function mutations in the Adenomatous Polyposis Coli (APC) tumour suppressor gene, and are largely refractory to current cancer immunotherapies. As presented in this thesis, examination of cancer gene expression profiles from CRC patients in large, publicly available online …
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Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies
<p>Mutations in the adenomatous polyposis coli gene are frequently associated with progression of colon carcinoma and most other types of epithelial carcinomas. This usually results in stabilization of β-catenin protein levels, followed by transactivation of Tcf-4/β-catenin responsive genes. The …
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An immunohistochemical study of beta-catenin in HNPCC colon tumours
Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane. If APC/beta-catenin is disrupted, beta-catenin transfers into the nucleus, where it functions as a transcriptional activator, causing unregulated …
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The role of APC in cellular and tissue organisation in intestinal tumorigenesis
The tumour suppressor adenomatous polyposis coli (APC) is a multifunctional protein regulating a diverse array of effector pathways essential for cellular homeostasis. In most sporadic colon cancers, truncating mutations in APC lead to the loss of the Wnt pathway and microtubule regulatory domains. …
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Regulation of MINK1 by APC, PKA and MARK3/4 and consequences for epithelial cell biology
… colorectal cancers the tumour suppressor gene adenomatous polyposis coli (APC) is mutated. The APC protein is closely linked to epithelial tissue homeostasis, it is a scaffolding protein in Wnt signalling and is important for cytoskeletal regulation. Misshapen/NIK-related kinase 1 (MINK1) was …
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The Non-Wnt Functions of APC: Unravelling the Link between APC and Apoptosis
… in the multi-functional tumour suppressor gene Adenomatous polyposis coli (<i>Apc</i>). The most commonly studied function of APC is its role as a scaffold for the β-catenin destruction complex involved in Wnt signalling. However, APC binds many other proteins. For example, it directly binds to …
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Microultrasound Imaging of Tissue Dysplasia
… morphology of WT (wild type) and ApcMin/+ (adenomatous polyposis coli) diverges with progressing age intervals (60, 90 and 120 days) of mice. A high frequency ultrasound scanning system was designed and the experiments were performed ex vivo using a focused 45 MHz, f-# = 2.85, µUS …
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Effects of Omega-3s and Vitamin E Prophylactic Diets and the Implications of Lipid Transport in Spinal Cord Injury
… and mature oligodendrocytes expressing the adenomatous polyposis coli protein (APC). Quantitative analysis of FAT/CD36 expression showed only Vitamin E upregulated this protein in neurons after SCI. Our findings support the complementary use of ω3PUFAs and Vitamin E to ameliorate motor, …
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Tumour suppression mediated through DPC4, p53 and APC
… deleted in pancreatic cancer locus 4), APC (adenomatous polyposis coli) and p53 have been implicated in pancreatic cancer in humans. This thesis firstly documents the in vivo effects of mutations in these genes singly and in combination through spontaneous and carcinogen- induced murine …
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Spatiotemporal dynamics of cell division in intestinal homeostasis
… are altered in tissue carrying mutations in Adenomatous polyposis coli (Apc), highlighting its importance for normal tissue homeostasis.<br/><br/>Secondly, I aimed to understand the dynamics of cell-cycle commitment in intestinal crypt compartments by investigating the DNA Replication …
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Familial adenomatous polyposis: a genotype - phenotype correlation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The biomechanical properties of epithelial cells and tissue in two and three dimensions
… cancer, by the expression of a truncated Adenomatous polyposis coli (APC) protein: N-APC. N-APC is present in most cases of colorectal cancer and provides a useful tool to study the early changes in colorectal cancer. MDCK cells form spherical cysts up to 100 μm in diameter with a hollow …
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