Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"adenocarcinoma (OAC)"”.
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Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma
The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and …
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A role for iron in oesophageal adenocarcinoma
… Western populations the incidence of oesophageal adenocarcinoma (OAC) is increasing greater than any other malignant disease. Increasing epidemiological and experimental evidence associates iron with OAC. Our understanding of iron physiology has increased enormously in recent years due to the …
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Deep Learning in Oesophageal Cancer Development: Integrating Multi-Stain Histopathology Images of the Capsule Sponge
… condition that increases the risk of oesophageal adenocarcinoma (OAC). Surveillance relies on endoscopy with random biopsies, a costly and invasive procedure that limits population-scale feasibility. The capsule sponge, a pan- oesophageal cell collection device, has emerged as a minimally invasive …
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Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma
… risk factor for the development of oesophageal adenocarcinoma (OAC) yet only 0.4%/year of non-dysplastic (ND) BE cases progress to cancer (Bhat et al., 2011). In this thesis I present the first comprehensive, multi-omics study comparing indolent, non-progressors with those who progressed to a …
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An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma
… Signatures in the Evolution of Oesophageal adenocarcinoma Sujath Abbas Oesophageal adenocarcinoma (OAC) remains a public health challenge with dismal survival rates and increasing incidence. This PhD study aimed to investigate how mutational processes act across different stages of OAC …
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Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma
… is a pre-malignant condition for oesophageal adenocarcinoma (OAC) [1], the incidence rate of which has been rising dramatically over the last four decades in the western world [2, 3]. Survival of an OAC affliction is poor, and one of the ways to improve this would be by focusing on identifying …
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A pathways-based approach identifying determinants of drug resistance in oesophageal adenocarcinoma
… <br/>Five-year survival rates for oesophageal adenocarcinoma (OAC) remain poor at approximately 15%. The development of drug-resistance limits the effectiveness of current chemotherapies, with less than 20% of patients experiencing complete pathological response, so the discovery of underlying …
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A Compendium of Genetic Drivers for Oesophageal Adenocarcinoma defines Prognostic and Therapeutic Biomarkers for use in the Clinic
Background: Oesophageal adenocarcinoma (OAC) is a poor-prognosis cancer type with rapidly rising incidence. Understanding of the genetic events driving OAC development is limited, and there are few molecular biomarkers for prognostication or therapeutics. This study aimed to use a large cohort of …
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Elucidating TRPA1 Ion Channel Aberrations in Oesophageal Adenocarcinoma.
Oesophageal adenocarcinoma (OAC) is the 14th most common cancer, accounting for 5% of cancer mortalities in the UK. The genomic landscape of OAC is driven by structural variations and is characterised by high mutation burden. Although recurrent mutations are observed in only few genes, we have …
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Avian leukosis virus as a risk factor for ovarian adenocarcinoma in layer hens
… of a suitable animal model. Ovarian adenocarcinoma (OAC) occurs spontaneously in hens, as in women, and increases in prevalence with age. Ovarian adenocarcinoma in women and hens have similar histologic features, biomarker staining and epidemiological characteristics. Recently, human …
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Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma
The development of oesophageal adenocarcinoma (OAC) from Barrett’s oesophagus provides an excellent model of the step-wise progression of malignancy. This process is strongly associated with the reflux of stomach contents into the oesophagus. However the exact mechanism by which low pH and bile …
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Cоx-2 inhibitоrѕ in Оeѕоphаgeаl Cаncer
… reflux (GORD) and the risk of Oesophageal adenocarcinoma (OAC). Hence I carried out a case control study looking into any association between ingestion of NSAIDs and drugs which may relax the lower oesophageal sphincter and oesophageal cancer. Case-control study: Methods: 411 patients in …
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Integrating Epidemiological and Genomic Factors to Inform Outcomes in Barrett’s Oesophagus and Oesophageal Adenocarcinoma
The incidence of oesophageal adenocarcinoma (OAC) has rapidly increased, and its prognosis remains poor. Barrett’s oesophagus (BO) is considered the precursor to OAC, however, BO is not apparent adjacent to tumour in nearly half of OAC patients. We have previously demonstrated that patients with …
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Analysis of driver gene mutations in oesophageal squamous cell carcinoma
… worldwide. The two main subtypes are oesophageal adenocarcinoma (OAC) and oesophageal squamous cell carcinoma (OSCC). OAC is more common in North America and Europe, while OSCC predominantly occurs in Eastern Asia, Sub-Saharan Africa and Latin America. Over 80% of the OSCC cases and deaths …
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Physical activity and Gastrointestinal Cancer: A deeper understanding of risk and underlying mechanisms
… with a 38% reduced risk of oesophageal<br/>adenocarcinoma (OAC) (HR 0.62, 95% CI 0.43–0.89). This work has been published in the United European Gastroenterology Journal in 2018 (Kunzmann*, Mallon* et al, United European Gastroenterol J. 2018 Oct;6(8):1144-1154; *Joint first …
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The Use of 2D and 3D Models to Study Competition in the Context of Barrett’s Oesophagus and Oesophageal Adenocarcinoma
**Introduction**: Oesophageal adenocarcinoma (OAC) is a cancer with poor five-year survival which is mainly due to its late diagnosis. OAC develops through an identifiable pre-cursor stage, Barrett’s Oesophagus (BO). BO can progress via the accumulation of further genetic and morphological changes …
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
Introduction Oesophageal adenocarcinoma (OAC) remains a poor prognosis cancer type. The pre-malignant lesion for this type of cancer is called Barrett’s Oesophagus (BO), which has two subtypes, Gastric Metaplasia (GM) and Intestinal Metaplasia with GM (IM). Both BO and OAC are genetically …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
Introduction Outcomes in oesophageal adenocarcinoma (OAC) are poor, largely driven by most patients being diagnosed at a late stage. OAC has a metaplastic pre-cursor lesion, Barrett’s oesophagus (BO), which can be monitored and effectively treated if dysplasia develops. Screening for BO could …