Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 527 for “"adenocarcinoma"”.
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Cariometria digital em adenocarcinoma de pâncreas
O adenocarcinoma de pâncreas continua sendo uma doença com alta mortalidade apesar dos avanços na ciência e na tecnologia. O diagnóstico é tardio, na maior parte dos casos, impossibilitando uma abordagem com fins curativos. Os estudos em busca de um método para o diagnóstico precoce ou mesmo um …
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Integrin alpha6beta4 contributions in pancreatic adenocarcinoma
Pancreatic adenocarcinomas are among the most lethal human cancers due to an elevated incidence of tumor cell invasion and metastasis for reasons that are currently unclear. In this dissertation, I determined how the pro-invasive integrin alpha6beta4 expression was related to pancreatic …
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Fator de Von Willebrand no adenocarcinoma colorretal
O adenocarcinoma colorretal é um dos tumores sólidos mais prevalentes no mundo, ocupando a terceira posição em ambos os sexos, precedido pelo carcinoma de pulmão e estômago em homens, e pelo carcinoma de mama e cérvix em mulheres. No Brasil, o adenocarcinoma colorretal está entre as cinco …
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Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma
… in some cancers, including pancreatic ductal adenocarcinoma (PDAC). There have been several published studies regarding CYP3A5 regulators, but there is still much to be discovered concerning CYP3A5 regulation in cancer. To further understand the regulation of CYP3A5, a high-throughput screen …
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T Cell Immunosurveillance in Pancreatic Ductal Adenocarcinoma
… T CELL IMMUNOSURVEILLANCE IN PANCREATIC DUCTAL ADENOCARCINOMA Rebecca A. Evans Robert H. Vonderheide The prevailing theory of cancer immune surveillance, as understood from carcinogen-driven mouse models of highly mutated tumors, states that T cell-mediated immune pressure drives a continuum of …
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A role for iron in oesophageal adenocarcinoma
… Western populations the incidence of oesophageal adenocarcinoma (OAC) is increasing greater than any other malignant disease. Increasing epidemiological and experimental evidence associates iron with OAC. Our understanding of iron physiology has increased enormously in recent years due to the …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… correlating with poor clinical outcome of lung adenocarcinoma patients. PCDH7 knockout in established lung tumor xenografts led to a significant decrease in phospho-EGFR, leading us to hypothesize that PCDH7 may directly interact with EGFR and modulate signaling through this receptor. We …
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Therapeutic Targeting of Protocadherin 7 in Lung Adenocarcinoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… correlating with poor clinical outcome of lung adenocarcinoma patients. PCDH7 knockout in established lung tumor xenografts led to a significant decrease in phospho-EGFR, leading us to hypothesize that PCDH7 may directly interact with EGFR and modulate signaling through this receptor. We …
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Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
… (SDC1), as a key effector for pancreatic ductal adenocarcinoma (PDAC) progression whose surface expression is driven by KRAS*. By leveraging various PDAC models, we found that surface SDC1 expression was initially diminished upon mutant KRAS (KRAS*) signaling blockade but recovered in tumor cells …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
Introduction Outcomes in oesophageal adenocarcinoma (OAC) are poor, largely driven by most patients being diagnosed at a late stage. OAC has a metaplastic pre-cursor lesion, Barrett’s oesophagus (BO), which can be monitored and effectively treated if dysplasia develops. Screening for BO could …
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Elucidating TRPA1 Ion Channel Aberrations in Oesophageal Adenocarcinoma.
Oesophageal adenocarcinoma (OAC) is the 14th most common cancer, accounting for 5% of cancer mortalities in the UK. The genomic landscape of OAC is driven by structural variations and is characterised by high mutation burden. Although recurrent mutations are observed in only few genes, we have …
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Transcriptional regulation of metastatic progression in lung adenocarcinoma
… cells that contribute to metastasis of lung adenocarcinoma, the major subtype of lung cancer. Using a genetically-engineered mouse model and derivative cell lines, we showed that metastatic lung adenocarcinoma cells are capable of forming proteolytic membrane protrusions known as invadopodia …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… invasion and metastasis of pancreatic ductal adenocarcinoma (PDA) and immune regulation, through modulation of the activity of regulatory T-cells (Treg), a subset of T-cells that suppress the immune system and maintain immune tolerance. In three common PDA cell lines, AsPC-1, PANC-1, and MIA …
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Investigating The Role of Cd109 In Pancreatic Ductal Adenocarcinoma
<p>Pancreatic Ductal Adenocarcinoma (PDAC) is the 3rd leading cause of cancer death in the US. We performed loss of function genomic screening on a cohort of four patient derived PDAC cell populations and our data shows a cell surface receptor CD109 to be a common vulnerability, the biologic role …
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Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma
… is a pre-malignant condition for oesophageal adenocarcinoma (OAC) [1], the incidence rate of which has been rising dramatically over the last four decades in the western world [2, 3]. Survival of an OAC affliction is poor, and one of the ways to improve this would be by focusing on identifying …
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Epidemiological risk factors, related biomarkers and oesophageal adenocarcinoma survival
… the western world the incidence of oesophageal adenocarcinoma has surpassed that of oesophageal squamous cell carcinoma and continues to rise. This highlights the necessity for further research to identify modifiable risk factors which can impact on the development and outcome of oesophageal …
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Flow cytometric analysis of endometrial hyperplasia and endometrial adenocarcinoma
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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ZNF300 may influence the metastatic properties in pancreatic ductal adenocarcinoma
… promote the tumorigenesis of pancreatic ductal adenocarcinoma (PDAC). Moreover, due to the overwhelming number of PDAC patients presented with metastasis at the time of diagnosis, it is necessary to better understand the process of metastasis. To understand the role of DNA methylation may in the …
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Upper gastrointestinal adenocarcinoma: associations with gastric secretory function and gender
… cancer worldwide. The incidence of oesophageal adenocarcinoma is rising rapidly, three-fold in the last two decades. The incidence of adenocarcinoma of gastric cardia is stable. In the pathogenesis of both gastric and oesophageal adenocarcinomas, the state of the gastric mucosa and its secretory …
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