Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"adefovir"”.
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Multidrug-Resistant Hepatitis B Virus Resulting From Sequential Monotherapy With Lamivudine, Adefovir, and Entecavir: Clonal Evolution During Lamivudine Plus Adefovir Therapy
… sequential monotherapy with lamivudine (LAM), adefovir (ADV), and entecavir (ETV) during LAM plus ADV salvage therapy. METHODS: Sera were obtained from 6 patients who had developed sequential resistance to LAM, ADV, and ETV before and during LAM plus ADV therapy. The HBV genomes from each …
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Factors affecting initial virologic response and emergence of resistant mutants after adefovir treatment in lamivudine resistant chronic hepatitis B patients
BACKGROUNDS: Adefovir dipivoxil effectively inhibits both wild-type and lamivudine-resistant hepatitis B virus replication. The development of adefovir resistance is delayed and infrequent compared with lamivudine resistance. The aim of this study was to characterize the serologic, biochemical and …
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Emergence of Adefovir-resistant Mutants after Reversion to YMDD Wild-type in Lamivudine-resistant Patients
… to occur up to 67% by 4 years of therapy. Adefovir dipivoxil (ADV) has been applied for the LAM-resistant patients, and it has shown to be effective against both wild-type and LAM-resistant forms of HBV. A pilot study in patients with LAM resistance showed no differences in HBV DNA …
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Low efficacy of entecavir therapy in adefovir-refractory hepatitis B patients with prior lamivudine resistance.
"본 연구에서는 이전에 라미부딘 및 아데포비어 내성을 보였던 환자를 엔테카비어로 전환하여 치료하여 이후 발생된 바이러스 반응, 엔테카비어 내성 및 라미부딘과 아데포비어 내성변종의 발현을 관찰하였다. 대상 환자는 예전에 라미부딘 내성을 보였던 아데포비어 내성 환자 중에서 6개월 이상 엔테카비어를 복용한 40명의 환자를 대상으로 하였으며 이들 환자에서의 바이러스 반응 및 엔테카비어 내성을 모니터링하였다. 전체 10% 환자에서 24주 동안의 엔테카비어 치료로 HBV DNA가 50 (copies/mL) 이하가 되었으며 40명의 환자 중 …
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Association of Lamivudine-Resistant Mutational Patterns with the Antiviral Effect of Adefovir in Patients with Chronic Hepatitis B
… 8 A. Virologic and biochemical response to adefovir 8 B. Antiviral efficacy of Adefovir between the HBeAg-positive and -negative Groups 8 C. Baseline hepatitis B virus polymerase mutations 8 D. Effect of lamivudine-resistant mutational pattern on the virologic and biochemical response to …
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Analysis of Treatment Effect of Lamivudine, Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis
Background: Add on adefovir (ADV) to ongoing lamivudine (LAM) is an established treatment modality for treatment of LAM resistance with chronic hepatitis B. We assessed the long?term efficacy (median follow-up of 20.18 months) of ADV add-on LAM therapy in 89 LAM-resistant patients. Methods: 89 …
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Analysis of Treatment Effect of Lamivudine plus Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis
목적: 라미부딘은 만성 B형 간염의 1차 치료제로 널리 사용되어 왔으나 내성 발현이 잦은 단점이 있다. 이러한 단점을 극복하기 위해 아데포비어 병합 치료가 사용되고 있으나 한국인을 대상으로 한 연구 결과는 적은 편이다. 저자들은 라미부딘에 내성인 B형 만성 간염 환자를 대상으로 라미부딘과 아데포비어 병합 치료 효과와 바이러스 돌파 현상을 확인하고자 하였다. 방법: 2005년 8월부터 2010년 10월까지 본원에서 라미부딘 투여 중 내성이 발생한 후 아데포비어를 추가？？여 치료한 환자 중 12개월 이상 치료받은 93명을 대상으로 …
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Synthesis of phosphorus/sulfur-based antivirals
… chapter. The preparation of the antiviral agent adefovir is detailed in Chapter 2. The derivatisation of adefovir via the corresponding phosphonic dichloride intermediate and under Garegg-Samuelsson reaction conditions is further discussed. The preparation of novel butyl and dibutyl phosphonate …
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Development and characterization of an in vitro culture system as a physiological model for chronic Hepatitis B infection
… available therapeutics (e.g. IFNca, lamivudine, adefovir, etc.) that include limited efficacy and the promotion of drug-resistant viral strains. These therapeutics are the research products of the HBV molecular biology that can be manipulated in the laboratory setting. Future antiviral drug …
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Design and synthesis of novel sulfur-containing antiviral analogues
… Our proposed synthetic target, an analogue of Adefovir Dipivoxil, is described alongside our rationale for studying this compound. Chapter Three details the model study which we conducted in order to assess possible synthetic routes to our target molecule. The highlight of this work was the …
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Durability after discontinuation of nucleos(t)ide therapy in chronic HBeAg negative hepatitis patients
… (25 with entecavir, 14 with lamivudine, 6 with adefovir.) All patients had followed up at least 1 year after stopping NUC therapy. Serum ALT, AST and HBV DNA levels were measured every 3 months. Clinical relapse was defined as HBV DNA>2,000 IU and ALT or AST > 2 times of upper limit of normal …
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Roles of Interferon Lambda on Hepatitis B Virus Replication
… of the viral polymerase, lamivudine and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and by the substantial resistance of the virus to nucleosidic inhibitors. New antiviral molecules suitable for monotherapy or combination …