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Showing 1 to 20 of 280 for “"adduct"”.
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A Study of the Structure Of 1,1,2,2-Tetracyanocyclopropane-Methanol Adduct
In 1975 Danishefsky proposed that for homoconjugate addition to occur between a nucleophile and a cyclopropane, it was necessary for the cyclopropane to contain two activating groups, such as -COCR or -CN. The initial intent of this research was to investigate the possibility of similar reactions …
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Mutagenesis by the primary aflatoxin B₁ DNA adduct in Escherichia coli
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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The toxicity and mutagenicity of the aflatoxin B₁ formamidopyrimidine DNA adduct
… of specific chemical structures of AFBI adducts in order to determine which of these may be responsible for the mutations that may play a role in the formation of HCC. The primary DNA adduct formed by the epoxide of AFB is the 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFBI-N7-Gua) …
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Mutagenesis and genotoxicity of the major DNA adduct of Cis-diamminedichloroplatinum(II)
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1991.
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Transcriptional response and DNA adduct analysis of murine liver exposed to aflatoxin B₁ by Jeanette Louise Allen Fiala.
… are compared. At each time point the AFB1-DNA adduction level was used as a predictive biomarker of genetic risk. Enzymes that detoxify the AFB1-8,9-epoxide, the metabolite of AFB1 responsible for genetic effects, were expressed at lower levels in neonates, resulting in formation of a high …
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I. The Evaluation of Urea Adduct Fractionation of Waxes by X-Ray and Electron Diffraction and Other Techniques. Ii. The Structure of Metal Films on Glass Fibbils
Made available in DSpace on 2015-05-12T17:02:31Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 0009061.PDF: 5866288 bytes, checksum: 93ac0c228a8412b04d13867f0c55d763 (MD5) Previous issue date: 1954
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Photo-cross-linking and identification of nuclear proteins that bind to DNA containing a site-specific adduct of cis-[Pt(NH₃)(N-6-aminohexyl)-4-benzophenonamide)CI₂]
… Cisplatin can form several distinct DNA adducts, which are toxic to cells if not repaired. By identifying proteins that bind to platinum-modified DNA, the work in this thesis focuses on the early stages of DNA adduct processing. The first chapter of this thesis gives a review of the …
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The kinetics of the arsenic(III) - chromium(VI) reaction on acetic acid-acetate buffers
… is the formation of an arsenic-chromium adduct in which either the acid chromate or dichromate ion is involved. A second possible mechanism postulates adduct formation involving only the acid chromate ion, followed by a CrO₄= catalyzed decomposition of the adduct. In either suggested …
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A comprehensive ab initio study of gallium and arsenic containing molecules
… (TMG) (Ga(CH$\sb3$)$\sb3$), the arsine$\cdot$TMG adduct, gallane (GaH$\sb3$), the gallane$\cdot$arsine adduct, small Ga$\sb{x}$As$\sb{y}$ clusters (x = y; x = 2-4), and small gallium hydrides are carried out at the self consistent field (SCF) Hartree-Fock level of theory, using analytic energy …
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The Effect of Ethanol and Acetaldehyde on Formation and Repair of Carcinogen-Dna Adducts in the Mammary Gland
… are capable of enhancing carcinogen-DNA adduct formation and inhibiting removal. However, these effects are dependent on the concentrations of ethanol or acetaldehyde, the time of exposure and the dose of carcinogen. Additionally, these effects, particularly those related to adduct …
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Oligosaccharide Analysis via Anion Attachment Using Negative Mode Electrospray (ES) and Matrix Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry
Eleven tested anions were able to form adducts with neutral oligosaccharides at low cone voltage in negative ion mode electrospray mass spectrometry. Among them, fluoride and acetate have the abilities to significantly enhance the absolute abundance of [M-H]- for neutral oliogosaccharides. The …
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Initial Studies on a Novel Target-Promoted DNA Alkylation System
… with the biaryl system. Only one deoxynucleoside adduct was observed when dA or dG reacted with quinoline or naphthalene QM precursor, in which both dA adducts degraded with time, while dG adducts remained unchanged after 72h at room temperature. The quinoline dG adduct was fully characterized as …
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Breast Cancer Inhibition by Grape Constituents
… and on the in vivo formation of rat mammary DNA adducts in female Sprague-Dawley rats. We found that specific constituents or combinations of phytochemicals in purple grape juice can block the initiation stage of DMBA-induced rat mammary tumorigenesis. This tumor inhibitory effect was associated …
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Mechanisms of toxicity and carcinogenicity of three alkylanilines
… the metabolic activation of and DNA adduct formation by these chemicals is an important first step in elucidating their mechanisms of carcinogenesis and toxicity. Cytochrome P450-mediated metabolism was profiled based on the hypothesis that N-hydroxylated metabolites are critical …
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Cancer Chemoprevention by Curcumin and Structurally Related Beta-Diketones
… effective in inhibiting in vivo mammary DMBA-DNA adduct formation. This inhibitory effect on mammary adduct formation was associated with a significant increase in liver activities of glutathione S-transferase, QR and 7-ethoxyresorufin-O-deethylase activities. Female rats provided diets …
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Synthetic and chromatographic study of the spiro-lactams and spiro-lactones based on a 9',10'-dihydro-(9,10)-ethanoanthracene Diels-Alder adduct. Application of flash vacuum thermolysis towards synthesis of exo-methylene lactones and lactams
… (9,10) -ethanoanthracene Diels-Alder adduct has been performed. Control of relative stereochemistry at the C2 and C2, C3 carbons on the lactone ring during synthesis of the spiro-lactones has been observed and is dependent on the reaction temperature and the length of reaction time.
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High-resolution NMR spectroscopic analysis of anticancer drugs, DNA and their interactions: 1. Platinum anticancer compounds - DNA interactions. 2. Anthracycline drugs - DNA interactions and modified DNA
… the major intrastrand cisplatin-G$\rm\sp*pG\sp*$ adduct has been studied and this intrastrand cisplatin-crosslinked adduct appears to be converted into an interstrand crosslink adduct. Three palindromic DNA oligonucleotides, each having a single intrastrand cisplatin crosslinked at GpG site, have …
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