Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 338 for “"adaptor"”.
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Phase Transitions of Multivalent Adaptor Proteins
Eukaryotic cells efficiently organize their activities to achieve their functional capabilities. This organization of biochemical reactions is a direct result of the cells' ability to compartmentalize their molecules. For example, within a eukaryotic cell, compartments like the nucleus, the …
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Role of Adaptor Proteins in MPR sorting
… Transport der Rezeptoren erfordert die monomeren Adaptor-Proteine GGA und den heterotetrameren Adaptor-Protein Komplex AP-1. Wir generierten und analysierten chimere Proteine der Rezeptor-bindenden Untereinheit µ1 des AP-1 und der homologen µ2 Untereinheit des AP-2 Komplexes der Plasmamembran und …
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Kernel-adaptor interface testing of Project Timeliner
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1995.
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Characterisation of the AP-3 adaptor-like complex
… coat consists of two components, clathrin and adaptor (or AP) complexes, the AP-1 complex is associated with the clathrin coated vesicles that bud from the TGN and the AP-2 complex is associated with the clathrin coated vesicles that bud from the plasma membrane. A new type of adaptor-like …
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Characterization of the ADA/GCN5 transcriptional adaptor complex
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Binding properties of adaptor proteins Tollip and Tom1
Adaptor proteins, like Tollip and Tom1, facilitate cellular cargo sorting through their ubiquitin-binding domains. Tollip and Tom1 bind to each other through their TBD and GAT domains, respectively, whereas Tollip interacts with phosphatidylinositol-3-phosphate (PtdIns(3)P)-containing endosomal …
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Regulation of inflammatory TLR signalling by the BCAP adaptor
BCAP is a PI3K adaptor protein in TLR, BCR and IL-1R and TCR signalling. In TLR signalling, BCAP acts as a negative regulator of inflammatory signalling. Regulation of TLR signalling is essential as overstimulation can cause excessive and pathological inflammation, which leads to serious illnesses …
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The characterization of adaptor protein homologues in Plasmodium falciparum
… in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The …
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Investigating the Role of Adaptor Protein ShcD in the Oligodendrocyte Lineage
… for the coordination of neuronal signaling. Adaptor protein ShcD is highly expressed in oligodendrocyte progenitor cells (OPCs), with a gradual reduction across differentiation to mature OLs. Utilizing ShcD wildtype (WT) and ShcD knockout (KO) mice, we investigated the role of ShcD within …
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The role of adaptor proteins Crk and CrkL in lens development
… fiber cell elongation have not been identified. Adaptor proteins Crk and CrkL are SH2- and SH3-containing proteins that transduce signals from upstream tyrosine phosphorylated proteins to downstream effectors, including Ras, Rac1 and Rap1, which are important for cell proliferation, adhesion and …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… the relevance and mechanisms of PLEKHS1 adaptor protein function to oncogenic PI3K pathway remodelling in human cancers, with a focus on prostate cancer. TCGA pan-cancer analyses report *IRS1* downregulation and *PLEKHS1* upregulation in several primary carcinomas, compared to healthy …
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The role of adaptor protein Mal/TIRAP in transducing TLR signalling
… developing targeted therapies. Mal/TIRAP is an adaptor protein and the first intracellular component of the TLR4 and TLR2 signalling pathways. In the traditional model of signalling, ligand stimulation dimerises TLR4 and TLR2 which then recruits Mal/TIRAP. Mal/TIRAP links the TLRS to the …
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Interaction between the AAA+ protease CIpXP and the adaptor protein SspB
… tags or degrons. Accessory proteins called adaptors can also modulate substrate selection by proteases. These adaptors have the potential to affect substrate specificity as well as expand the repertoire of substrates that can be degraded by proteases. Understanding how proteases interact …
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Genetic and biochemical characterization of the ADAs, a transcriptional adaptor complex
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Mechanism of active substrate delivery by the AAA+ protease adaptor CIpS
… substrates into an associated peptidase barrel. Adaptor proteins assist in recognition and degradation of certain substrates, but how enzyme-adaptor pairs ensure proper substrate selection is incompletely understood. In this thesis I focus on the delivery mechanism employed by the bacterial …
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Insights into the role and mechanism of the AAA+ adaptor Clps
… with respect to substrate selectivity. Adaptor proteins that can associate with the proteases add an additional layer of control to substrate selection. Thus, understanding the mechanism and role of adaptor proteins is a critical component to understanding how proteases choose their …
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Role of the adaptor protein, beta-arrestin1, in the Notch signaling pathway
… homologues of Kurtz and functions as an adaptor protein in a variety of cellular processes such as endocytosis, ubiquitination and nuclear shuttling. We hypothesize that a similar interaction occurs in mammalian cells between Notch, beta-arrestin1 and Deltex to negatively modulate the …
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σ1-adaptin - the Small Subunit of the Clathrin Adaptor Complex AP-1
Der Adaptorkomplex AP-1 ist ein heterotetramerer Proteinkomplex, der an der Bildung von Clathrin-Vesikeln am trans-Golgi Netzwerk und an Endosomen mitwirkt. Durch die Bindung an Phosphatidylinositol-4-phosphat, an ARF-1 und an Sortierungssignale der transportierten Proteine gelangt der Komplex an …
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An investigation of the function of adaptor protein complex 4 (AP-4)
… bound transport intermediates by vesicle adaptors, which include those of the highly conserved adaptor protein (AP) complex family. Each AP complex has a distinct subcellular localisation and functions in the sorting of a specific subset of transmembrane cargo proteins. Adaptor protein …
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Structural and functional characterisation of pUL21, an α-herpesvirus phosphatase adaptor protein
… the role of pUL21 as a novel viral phosphatase adaptor that recruits PP1 to multiple substrates, including CERT, to promote their dephosphorylation. Conservational and structural analyses led to the discovery of a non-canonical linear motif in pUL21, termed TROPPO, that is critical for PP1 …
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