Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"adaptive randomization"”.
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A Signature Enrichment Design With Bayesian Adaptive Randomization For Cancer Clinical Trials
… more flexible and efficient trial designs. Adaptive clinical trial designs allow pre-specified modifications of an on-going clinical trial and could shorten the trial duration. We reviewed five common types of adaptive clinical trials based on adaptation methods. In particular, …
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Addressing the Analytical and Computational Challenges Using Machine Learning in Biomedical Research
… challenges spanning diverse areas, including adaptive clinical trial designs, survival analysis, and high-dimensional genetic data analysis. Specifically, Chapter 2 focused on the application of ML in response-adaptive randomization designs. Compared to a traditional equal-randomization …
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Bayesian Adaptive Designs for Early Phase Clinical Trials
… of patients with the same disease. A Bayesian adaptive umbrella trial design is proposed to select effective targeted agents for different biomarker-based subgroups of patients. To facilitate treatment evaluation, the design uses a mixture regression model that jointly models short-term and …
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From data to decisions in healthcare : an optimization perspective
… higher than, state-of- the-art covariate-adaptive randomization approaches. In Part II, we present a mixed-integer optimization approach for identifying exceptional responders in randomized trial data. In practice, this approach can be used to extract added value from costly clinical …
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Preparing, Executing, and Designing Complex Clinical Trials Using Simulations
… comparative effectiveness Bayesian response adaptive randomized trial; continued work to detail the execution of this study and assess if any treatment outcome drift should have been accounted for; and lastly, using data-driven simulations to compare a proposed statistical model with an …
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Asymptotically robust permutation tests for two-sample goodness-of-fit testing problems
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Further Advances For The Sequential Multiple Assignment Randomized Trial (Smart)
… have been developed these years for studying adaptive interventions. In my Ph.D. study, I mainly investigate how to further improve SMART designs and optimize the interventions for each individual in the trial. My dissertation has focused on two topics of SMART designs.</p> <p>1) Developing a …