Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"adaptive radiotherapy"”.
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Evaluation of Timepoint Assessment Schemes for Offline Adaptive Radiotherapy of the Head and Neck Using Velocity
The use of adaptive radiotherapy (ART) may improve care for those receiving head and neck cancer treatment by reducing dose to organs at risk (OARs) and allowing margin reduction for targets. Current literature investigates predetermined and triggered adaptation, but how to trigger and how often to …
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Head and Neck Cancer Offline Adaptive Radiotherapy Proof-of-Concept Workflow for Low-Resource Clinics Utilizing NTCP
Adaptive Radiotherapy (ART) is a tool with the potential to improve head and neck (H&N) cancer patient outcomes by creating new treatment plan(s) throughout the treatment regimen, reducing dose to nearby organs at risk (OAR) whenever possible. While online ART makes use of specific and costly …
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Quantifying, Understanding and Predicting Differences Between Planned and Delivered Dose to Organs at Risk in Head & Neck Cancer Patients Undergoing Radical Radiotherapy to Promote Intelligently Targeted Adaptive Radiotherapy
Introduction: Radical radiotherapy (RT) is an effective but toxic treatment for head and neck cancer (HNC). Contemporary radiotherapy techniques sculpt dose to target disease and avoid organs at risk (OARs), but anatomical change during treatment mean that the radiation dose delivered to the …
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Development and Realization of the IGRT Inline Concept
… system into a medical linear accelerator for radiotherapy is presented, and its technical realization is described. An x-ray tube and a flat panel detector were installed along the treatment beam axis, such that the detector could not only be used for x-ray imaging of patients lying on the …
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Polymer Gel Dosimetry in Magnetic Resonance-Image Guided Radiation Therapy
… a radiation therapy treatment unit allows for adaptive radiotherapy guided by MR imaging (MR-IGRT) and has been proposed as an advanced radiotherapy treatment modality. The delineation of the tumor and adjacent organs is greatly improved by the soft tissue contrast available from MR images. …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
… tumor microenvironment (TME), and optimized radiotherapy delivery with cGAMP and systemic α-PD-L1 immunotherapies. Using MSC, we delivered various forms of anti-CD3 and/or co-signals to explore their contribution to re-activate T cells inside the TME. Combined α-CD3 and CD40L rather than CD80 …
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Ai-Enabled Online Plan Adaptation For Mr-Guided Stereotactic Ablative Radiotherapy (Sabr) of Head and Neck Cancer
… cancer type worldwide. Stereotactic ablative radiotherapy (SABR) has emerged as an effective treatment for HNC, delivering highly conformal doses to the tumor target while sparing surrounding normal tissues with a sharp dose gradient. However, the accuracy of the treatment delivery is limited …
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Diffeomorphic image registration with applications to deformation modelling between multiple data sets
… with low quality data typically encountered in Adaptive Radiotherapy (ART). The research has led to the main emphasis being laid on the diffeomorphic image registration to achieve one-to-one mapping between images. This involves introduction of the log-domain parameterisation of the deformation …
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Artificial Intelligence (AI)-assisted Cardiotoxicity Management in Lung Cancer Radiotherapy
… of life. There is increasing evidence that post-radiotherapy cardiotoxicity is better indicated by cardiac substructure dose, compared with whole heart dose. Despite this, cardiac substructures are not routinely incorporated into clinical workflows due to the significant time and resource demands …
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Applications of cone beam computed tomography in radiotherapy treatment planning.
In recent years Image-Guided Radiotherapy (IGRT) has experienced many technical advances. One of the most significant has been the widespread implementation of kilovoltage imagers attached to the gantry of linear accelerators (LINACs); these units are capable of 2D planar imaging, fluoroscopy and …
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Accumulating delivered dose to the rectum to improve toxicity prediction in prostate radiotherapy
… to improve toxicity prediction in prostate radiotherapy Leila E. A. Shelley Gastrointestinal (GI) toxicity is a clinical issue suffered by up to 22% of prostate cancer radiotherapy patients. However, the relationship between radiation dose and toxicity is generally poorly understood. In …
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Range Adaptive Proton Therapy For Prostate Cancer
… range at the prostate-rectal interface and adaptively adjusting the range in vivo and in real-time. Materials and Methods: A prototype device, consisting of an endorectal liquid scintillation detector and dual-inverted Lucite wedges for range compensation, was designed to test the …