Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 168 for “"adaptive immunity"”.
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Adaptive Immunity in Cardiovascular Disease
… This thesis presents and discusses aspects of immunity, which are interesting targets for pharmaceutical intervention. Various components of adaptive immunity may be useful as biomarkers for determining patients with increased risk of developing CVD.
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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… of eTreg cells and the development of fatal autoimmunity. In Chapter 4, we further explored the mechanistic role of protein prenylation in the regulation of eTreg cells by performing a comprehensive analysis of protein prenylation-dependent molecular signaling in eTreg-cells. Specifically, we …
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Equine innate and adaptive immunity to viral infections
Activation of innate immunity through Toll-like receptor (TLR) signaling can also enhance antigen-specific adaptive immunity. TLR9 is an endosomal receptor for unmethylated bacterial and viral cytosine-phosphate-guanine DNA (CpG-DNA). West Nile virus (WNV) infection may result in meningitis and …
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STING Signaling in Adaptive Immunity and Respiratory Physiology
The author publishes under the names Kennady Knox and Kennady Abbott.
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Cas9-Primed Adaptive Immunity During the CRISPR-Cas Response
… (CRISPR) loci provide archaea and bacteria with adaptive immune systems that allow them to counteract these rapidly evolving genetic parasites. These diverse systems all generally contain two components: a set of CRISPR-associated (cas) genes and a series of repetitive DNA elements intercalated …
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Evading Innate and Adaptive Immunity During Adenovirus Cell Entry
<p>Adenovirus (Ad), a non-enveloped, dsDNA virus, enters cells via clathrin-mediated endocytosis. For viral genome delivery to the nucleus, Ad must penetrate endosomal membranes to create defects sufficient for the passage of the 90 nm diameter capsid across cell membranes. Recent observations …
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Cellular Uptake of Neutrohpil Elastase Links Inflammation to Adaptive Immunity
… of inflammation providing evidence that innate immunity is a critical component in the development and progression of cancer. Neutrophils are primary mediators of the innate immune response. Upon activation, an important function of neutrophils is release of an assortment of proteins from their …
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Characterization of endocytic escape pathway and its role in adaptive immunity
… endocytic escape pathways contribute to adaptive immunity.
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Nod1 and Nod2 in Innate Immune Responses, Adaptive Immunity and Bacterial Infection
… of seminal discoveries in the field of innate immunity. The discovery that microbial molecules and endogenous danger signals can be detected by germ-line encoded receptors has changed the way we study the immune system. Indeed, the characterization of Toll in Drosophila as a sensor of microbial …
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IL-27 AND THE REGULATION OF INNATE AND ADAPTIVE IMMUNITY DURING TOXOPLASMOSIS
… points during infection to limit key innate and adaptive events that contribute to infection-induced pathology.
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The role of adaptive immunity in Parkinson's pathology following traumatic brain injury
… synuclein propagation. To examine the role of adaptive immunity in these outcomes, Rag2 KO mice were exposed to the same experimental conditions and displayed significant neuroprotection of the DA neuron population compared to wildtype animals. Taken together, these findings indicate the …
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Restriction-Modification and CRISPR-Cas Systems: Cooperation Between Innate and Adaptive Immunity in Prokaryotes
… RM systems, CRISPR-Cas systems represent an adaptive immune response because they require an initial exposure to a virus in order to become successfully immunized through the acquisition of new spacer sequences. CRISPR-Cas and RM are two of the most prevalent types of defense systems found in …
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Of Mice and Men: Studying Innate and Adaptive Immunity Against the Epstein-Barr Virus
<p>The Epstein-Barr virus (EBV) is a lymphotropic γ-herpes virus infecting over 90% of the human adult population. A striking feature that the virus shares with other γ-herpes viruses is its oncogenic potential. This transforming property can be observed as B cell transformation in vitro and …
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Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy
… and ribosomal activity changes in the adaptive immunity could reflect tumor-level therapeutic failure. We further characterized the T cell diversity in the tumors and discovered an early activated state and a terminally exhausted T cell state with therapeutic potential. Among the innate …
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Complement activation and effector pathways in ischaemia reperfusion injury and at the interface with adaptive immunity
… injury to the transplant and stimulates the adaptive immune response against transplant antigens. However uncertainty exists as to the exact trigger mechanisms of complement activation in this situation, and to the relative importance of certain effector molecules generated by complement …
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
… (ER) stress, the gut microbiome and ageing on adaptive immunity. Immune cells have been shown to integrate inflammatory signalling with the ER stress response pathway. This response is triggered by a variety of environmental stresses such as low nutrient availability, hypoxia and mechanical …
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The Functional Contribution of Adaptive Immunity In The Biology of Pancreatic Cancer and Therapeutic Targeting of Oncogenic Kras
<p>The Functional Contribution Of Adaptive Immunity In The Biology Of Pancreatic Cancer And Therapeutic Targeting Of Oncogenic Kras</p> <p>Krishnan K. Mahadevan M.B.B.S*</p> <p>Advisory professor: Dr. Raghu Kalluri</p> <p>Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer …
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Regulation of Adaptive Immunity in the Lung by the Alveolar Epithelial Type II Cell and Surfactant Protein a
… protein A (SP-A), have been linked to roles in adaptive immunity in the lung. The discovery that type II cells constitutively express major histocompatibility complex class II (MHC II) suggested that type II cells may function to present antigen to T cells. Studies in vitro demonstrated that …
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An Assessment of the Relationship among Oxidative Stress, Adaptive Immunity and Genetic Variations in the Chicken, Gallus gallus
… hypothesis of this dissertation is: The bird's adaptive immunocompetence is impacted by their OS level, which is not only influenced by environmental factors, but also related to genetic phenotype of either mitochondrial DNA (mtDNA) or nuclear DNA (nDNA). In the first phase of this study, White …
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Induction of Innate and Adaptive Immunity In Vivo by Selective Antibody Targeting of Poly dA:dT and Antigen to Dendritic Cells
… if these cells alone can integrate innate and adaptive immunity in vivo. Here we illustrate a novel method using expressed protein ligation (EPL) to attach the immune stimulant, poly dA:dT, to the DC uptake receptor, DEC205 (DEC). We will show that inoculation of α-DEC-poly dA:dT fusion …
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