Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 117 for “"adaptive immune response"”.
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… surveillance. The form and functionality of this adaptive immune reaction and why it fails when cancer develops remain unclear. In this work, I have studied the adaptive immune response to senescence using in vitro and in vivo models. I have used hydrodynamic tail vein (HDTV) delivery of …
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Mathematical modelling of the innate and adaptive immune response to solid tumours
… growth of a solid tumour in the presence of an immune response are presented. Specifically, attention is focused on the interactions between cytotoxic T-lymphocytes (CTLs) and tumour cells in a small, avascular multicellular tumour. At this stage of the disease the CTLs and the tumour cells are …
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Algorithms for single-cell phylogenetics to study tumor evolution and adaptive immune response
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
The CD8+ T cell responses play a pivotal role in controlling viral replication during HCV infection. HCV evades the immune system by rapid viral evolution affording escape from immune selection pressure including at MHC-I restricted epitopes. However, some CTL epitopes remain conserved well past …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… However, roughly 40% of patients exhibit no response, tumor recurrence or tumor progression following BCG treatment. Type I interferon (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an alternative treatment option for patients who do not respond to BCG …
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Glycan Shielding of the Influenza Virus Hemagglutinin Elicits Evasion of the Adaptive Immune Response and T-Cell-Driven Pathology
… sites to assess the impact on the host immune response. These studies show that mice infected with a glycosylated virus remain susceptible to challenge with a non-glycosylated virus, glycosylated viruses elicit an inferior immune response, and in this context T-cell pathology and death …
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Development of protein microarrays for the investigation of host-pathogen interactions
… The work presented here investigates the humoral immune response to VZV infection in more detail, to better understand the mechanisms of the adaptive immune response to lead to improved diagnostic tests and vaccine development.
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Investigating the role of innate lymphoid cells in targeted radiotherapy in lung cancer
… cancer treatment, and its role in regulating immune responses to promote anti-cancer response is increasingly appreciated. However, it is still not fully understood how radiotherapy modulates the immune microenvironment in lung cancer. In the lung, ILC2s are critical innate lymphocytes that …
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Mathematical Modelling and Statistical Inference from Immune Response Data
A hallmark of the adaptive immune response is the proliferation of pathogen-specific lymphocytes that leave in their wake a long lived population of cells that provide lasting immunity. A subject of debate is at which time point post infection those memory cells are produced during an adaptive …
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Immunomodulatory effect of pneumolysin upon CD4 T cells
… shown to modulate different parts of the innate immune response of its host, however its ability to modulate the adaptive immune response remains largely uninvestigated. Furthermore, the importance of the adaptive arm of the immune system in responding to Streptococcus pneumoniae has only …
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Mathematical models of immune responses during external challenges and autoimmunity
Characterizing the mechanisms of the immune system and its response to infection and autoimmunity is crucial for understanding and predicting disease outcomes and evaluating potential interventions at multiple scales. While data provide a snapshot of certain biological phenomena, they cannot …
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Immunology based methodology for detecting and searching anomalies
… but complex cooperative effort of the innate and adaptive immune response of the human immune system"--Abstract, page iii.
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Cellular immunity of naïve and BCG vaccinated neonates
… development of a type 1 helper (Th1) cytokine response, could impact on the subsequent adaptive immune response to BCG vaccination. Previous studies have suggested that immune responses in early life may be defective and related to the immaturity of antigen-presenting cells and/or T cells.
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An Assessment of the Relationship among Oxidative Stress, Adaptive Immunity and Genetic Variations in the Chicken, Gallus gallus
… the potential effects of OS on the poultry immune system are not well understood. In addition, the impact of bird genetic variation on redox balance remains to be elucidated. Thus, the central hypothesis of this dissertation is: The bird's adaptive immunocompetence is impacted by their OS …
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Antibody-Mediated Modulation of Polyclonal Immune Responses
… defense are sequentially activated: the innate immune response and the adaptive immune response. The innate immune response is the first line of defense, and consists mainly of myeloid cells that are quickly activated within hours to days to engage in a non-specific manner. This broad response …
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Early Events Following Oral Transmission of Simian Immunodeficiency Virus: From Viral Entry to Host Immune Response
… indicates a major obstacle for a vaccine recall immune response to eliminate infected cells prior to dissemination. Analyses of immunologic events through the assessment of mucosal innate immune gene expression, as well as the initiation of the adaptive immune response, were undertaken in a …
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Using the single-cycle flavivirus particle replivax to study flavivirus replication and immune response
… are highly immunogenic and induce an antiviral immune response without causing disease. The overall goal of this dissertation was to understand the interaction of RepliVAX with target cells, innate immune cells, and adaptive immune cells. The first studies investigated the properties of adaptive …
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The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection.
… are non-specific killer cells of the innate immune system that eliminate target cells based on discrimination between self and non-self. Activation is carefully regulated through integration of signals received through both activating and inhibitory receptors. During the course of a herpes …
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Incorporation of CpG Oligodeoxynucleotides into α2-Macroglobulin: Development of a Novel Vaccine Adjuvant Delivery Mechanism
… and rapidly binds to and is internalized by immune competent cells expressing the α2M* endocytic receptor, LRP, and is then trafficked to the endosome. Based on these interactions, α2M seems to play an important role at sites of infection and inflammation by controlling the level of …
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The scaffold protein POSH regulates T lymphocyte function
T lymphocytes are critical mediators of the adaptive immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, little is know as to how JNK activation is coupled to the TCR. This dissertation …
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