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Showing 1 to 2 of 2 for “"acylpeptide hydrolase"”.
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An Oxanthroquinone Derivative Disrupts Ras Plasma Membrane Localization and Function By Inhibition of Acylpeptide Hydrolase and Perturbation of Sphingomyelin Metabolism
… <p>When attached to a biotin moiety, G01 bound acylpeptide hydrolase (APEH) and blocked its enzymatic activity. Inhibition of APEH by ebelactone, an esterase inhibitor, or the knockdown of APEH mislocalized KRASG12V as well as phosphatidylserine from the PM. Together, these results suggest that …
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Proteome-wide Functional Profiling of Serine Hydrolases in the Human Malaria Parasite
The serine hydrolase (SH) enzyme superfamily is one of the largest and most diverse enzyme classes in eukaryotes and prokaryotes. The most virulent human malaria parasite Plasmodium falciparum has over 40 predicted serine hydrolases (SH). Prior investigation on a few of these have suggested their …