Global ETD Search
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Showing 1 to 12 of 12 for “"acylcarnitines"”.
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Development of gas chromatography/mass spectrometry analysis of urinary acylcarnitines : application to metabolism studies
… and novel derivatization procedure in which acylcarnitines are cyclized to give volatile lactones, amenable to GC and GC/MS. The technique was subsequently applied to acylcarnitines extracted from urine. As such, the method has been used to identify acylcarnitine metabolites in the urine of …
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
… a buildup of mitochondrial metabolites such as acylcarnitines. Carnitine, essential for fatty acyl-CoA transport through the inner and outer mitochondrial membranes, can be an indicator of mitochondrial distress as elevated levels tend to spill over into plasma suggesting a disruption in …
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Le comportement à jeun et en postprandial des acylcarnitines chez les patients avec un diabète de type 2 et ceux à haut risque de développer un diabète de type2.
… des concentrations plasmatiques augmentées d’acylcarnitines ont été proposées comme un marqueur d’une saturation mitochondriale et un débordement dans la circulation et semblent être associés à l’insulino-résistance et au développement du diabète de type 2. Pour évaluer un potentiel effet des …
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Biological activity of palmitoylcarnitine in prostate cancer
Acylcarnitines are intermediates of fatty acid oxidation and accumulate as a result of a metabolic defect. Accumulation of palmitoylcarnitine (palcar), a long-chain acylcarnitine, has been observed in diabetes mellitus type II, obesity and kidney cancer. Certain dietary intervention studies have …
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The Molecular Mechanism Of The Gwas Association Of The Slc22a1 Locus With Metabolic Traits
… and found that SLC22A1 exports short-chain acylcarnitines from the liver to the blood, regulating the systemic availability of hepatic carnitine species. Next, we sought to identify the causal variants of SLC22A1 for the genetic association with serum acylcarnitine levels. We refined the …
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A metabolomics investigation of in utero antiretroviral exposure to neonates
… high repeatability for a targeted analysis of acylcarnitines and amino acids in cord blood. Chapter 6 provides results that support the benefits of ART for HIV-infected pregnant women as recommended by the WHO, but the amino acid profiles of cord blood, and to a lesser extent of the …
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Third Trimester Plasma Metabolites Associated with Gestational Diabetes: An Ancillary Analysis of the Healthy Beginnings Trial
… Gestational diabetes mellitus, metabolomics, acylcarnitines, purines</p>
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Inclusion of Olive or Coconut Oil in a High-Fructose High-Fat Diet Increases Liver Injury in a Pig Model of Pediatric NAFLD
… and total cholesterol in blood, and increased acylcarnitines in liver, whereas COC increased triacylglycerides (TAGs) in liver and blood. All HFF diets increased bile acids in liver, and decreased choline and fibroblast growth factor 19 in liver and blood. OLI and COC increased hepatic …
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Partial Molecular and Biochemical Characterization of a Sandhoff Mouse Model
… in two metabolites of glycerophospholipids and acylcarnitines suggesting that the breakdown and synthesis is interrupted downstream of the GM2 Ganglioside storage. Lastly, consistent with other findings, we have shown amino acids (particularly alanine) to be elevated, which is a likely …
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The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… lipid intermediates. Importantly, release of acylcarnitines from SCs was toxic to axons and induced their degeneration. Our results show that normal mitochondrial function in SCs is essential for maintenance of axonal survival and normal peripheral nerve function, suggesting that SC …
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Linking whole-grain bread, coffee, and red meat to the risk of type 2 diabetes
… Concentrations of 126 metabolites (acylcarnitines, phosphatidylcholines, sphingomyelins, amino acids) were determined in baseline-serum samples. Incident type 2 diabetes cases were assed and validated in an active follow-up procedure. The median follow-up time was 6.6 years. …