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Showing 1 to 12 of 12 for “"acylcarnitine"”.
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The Molecular Mechanism Of The Gwas Association Of The Slc22a1 Locus With Metabolic Traits
… associations at the SLC22A1 locus for plasma acylcarnitine and low-density lipoprotein (LDL) cholesterol levels, suggesting previously unknown roles of SLC22A1 in the regulation of acylcarnitine and cholesterol metabolism. In this study, we aimed to investigate the molecular mechanism by which …
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
… a buildup of mitochondrial metabolites such as acylcarnitines. Carnitine, essential for fatty acyl-CoA transport through the inner and outer mitochondrial membranes, can be an indicator of mitochondrial distress as elevated levels tend to spill over into plasma suggesting a disruption in …
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Development of gas chromatography/mass spectrometry analysis of urinary acylcarnitines : application to metabolism studies
… and novel derivatization procedure in which acylcarnitines are cyclized to give volatile lactones, amenable to GC and GC/MS. The technique was subsequently applied to acylcarnitines extracted from urine. As such, the method has been used to identify acylcarnitine metabolites in the urine of …
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Exploring the Role of Mitochondrial Bioenergetics and Metabolism in Heart Failure
… early stage heart failure: 1) accumulation of acylcarnitine metabolites; 2) mitochondrial hyperacetylation; and 3) elevated ketone catabolism. The goal of this dissertation was to explore the role of these metabolic signatures in the pathogenesis of heart failure. </p><p>Tissue accumulation of …
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Inclusion of Olive or Coconut Oil in a High-Fructose High-Fat Diet Increases Liver Injury in a Pig Model of Pediatric NAFLD
… and total cholesterol in blood, and increased acylcarnitines in liver, whereas COC increased triacylglycerides (TAGs) in liver and blood. All HFF diets increased bile acids in liver, and decreased choline and fibroblast growth factor 19 in liver and blood. OLI and COC increased hepatic …
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Le comportement à jeun et en postprandial des acylcarnitines chez les patients avec un diabète de type 2 et ceux à haut risque de développer un diabète de type2.
… des concentrations plasmatiques augmentées d’acylcarnitines ont été proposées comme un marqueur d’une saturation mitochondriale et un débordement dans la circulation et semblent être associés à l’insulino-résistance et au développement du diabète de type 2. Pour évaluer un potentiel effet des …
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Biological activity of palmitoylcarnitine in prostate cancer
Acylcarnitines are intermediates of fatty acid oxidation and accumulate as a result of a metabolic defect. Accumulation of palmitoylcarnitine (palcar), a long-chain acylcarnitine, has been observed in diabetes mellitus type II, obesity and kidney cancer. Certain dietary intervention studies have …
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Wirkung von Sekretin auf Neurotransmitter im Hippokampus der Ratte
… von Aminosäuren und parallel dazu auch von Acylcarnitinen erfolgte mittels Tandem-Massenspektrometrie. Glutamat, gamma-Aminobuttersäure (GABA)und Aspartat wurden mittels Hochdruck-Flüssigkeitschromatographie (HPLC)und Fluoreszenzdetektion bestimmt. Zur Analyse der Katecholamine und …
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Broad Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β-cell Metabolism in the Absence of Dietary Overnutrition
… organic acid, amino acid or fatty acid-derived acylcarnitine metabolites during glucose stimulation. </p><p>We also studied mice with global SIRT3 knockout (KO) fed a standard chow (STD) or high-fat/high-sucrose (HFHS) diet. Importantly, we performed these studies in the C57Bl/6J background in …
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Protein-energy and carnitine status in patients with upper aerodigestive tract cancer
… by a shift in the relative amount of serum acylcarnitine and free carnitine especially in those at an advanced tumour stage. During cancer treatment, patients with UAT cancer at an advanced stage were more likely to be at risk for malnutrition during treatment than those at an early tumour …
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The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… components as well as a dramatic accumulation of acylcarnitine lipid intermediates. Importantly, release of acylcarnitines from SCs was toxic to axons and induced their degeneration. Our results show that normal mitochondrial function in SCs is essential for maintenance of axonal survival and …
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Towards the Design of Carnitine Acyltransferase Inhibitors: Modeling the Conformational Behavior of (<em>R</em>)-Carnitine, (<em>R</em>)-Acetylcarnitine, Morpholinium rings, and 2-Oxo-1,3,6-dioxazaphosphacinium rings
Full grid-search semiempirical calculations (AM1 and AM1/COSMO) on zwitterionic acetylcarnitine and carnitine, cationic acetylcholine and choline, and 3-acetoxypropanoate and 3-hydroxypropanoate in the gas phase and solution were performed. The calculated ΔH<sub>hydr</sub> for hydrolyses of …