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Showing 1 to 13 of 13 for “"acyl-CoA synthetase"”.
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Expression und Funktion der Acyl-CoA-Synthetase 5 in der humanen Epidermis
… ceramides have been described in this context. Acyl-CoA is involved in different interconnected metabolic pathways, so enzymes with an acyl-CoA-synthetase activity are of great importance within skin lipid metabolism as shown by the example of FATP4 deficient mice. Up to now, there is only few …
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A Role for ACSBG1 in Obesity-Accelerated Breast
… this pure cancer cell population identified the acyl-CoA synthetase, Acsbg1, as robustly upregulated in cancer cells isolated from tumors in obese compared to lean animals. Overexpression of Acsbg1 in tumor cells further enhanced tumor growth in an obesity-specific manner, which required intact …
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Design, synthesis, and evaluation of bioactive molecules; Chiral polyvinylpyrrolidones supported Cu/Au nanoclusters catalyzed cyclization of 5-substituted nona-1,8-dien-5-ols
… C analogs were designed as long chain fatty acyl-CoA synthetase (ACSL) inhibitors for attenuating ischemia and reperfusion (I/R) injury. Oxadiazole derivatives were designed as T-type calcium channel inhibitors, which have potential application in the treatment of seizure and epilepsy. …
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Inclusion of Olive or Coconut Oil in a High-Fructose High-Fat Diet Increases Liver Injury in a Pig Model of Pediatric NAFLD
… and total cholesterol in blood, and increased acylcarnitines in liver, whereas COC increased triacylglycerides (TAGs) in liver and blood. All HFF diets increased bile acids in liver, and decreased choline and fibroblast growth factor 19 in liver and blood. OLI and COC increased hepatic …
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The Metabolic Transitions Regulated by the Estrogen-related Receptor (ERR) in Drosophila melanogaster
… of an uncharacterized long-chain-fatty-acid acyl-CoA synthetase, CG4500, which is subject to induction by starvation. Furthermore, late L3 larvae of dERR mutants exhibit altered lipid profiles with elevated medium-chain and long-chain fatty acids. Together, with the previous finding that ERR …
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Untersuchungen zum Fettsäuretransport durch zelluläre und peroxisomale Membranen
… Arbeit sind wir der Frage nachgegangen, ob Acyl-CoA-Synthetasen am Fettsäuretransport in Saccharomyces cerevisiae beteiligt sind. In früheren Studien konnten wir zeigen, dass die kombinierte Deletion der Acyl-CoA-Synthetasen FAA1 und FAA4 in YB332 zu einem Fettsäuresekretions-Phänotyp führt, …
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Identification and preliminary characterization of the 2,5-diphenyloxazole biosynthetic pathway in streptomyces polyantibioticus SPRT
… was proposed, whereby a non-ribosomal peptide synthetase (NRPS) condenses a molecule of benzoic acid with 3-hydroxyphenylalanine. The dipeptide is converted to a diphenyloxazole derivative by heterocyclization and a final decarboxylation step leads to DPO. To determine whether the hypothesis …
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Identification and Characterization of Ethanol Responsive Genes in Acute Ethanol Behaviors in Caenorhabditis elegans
… of fatty acids, acs-2. acs-2 encodes an acyl-CoA synthetase that activates fatty acids for mitochondrial beta-oxidation. Animals carrying mutant acs-2 have significantly reduced AFT and we explored the role of genes in the mitochondria beta-oxidation pathway for alterations in ethanol …
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Palmitoyl-acyl Carrier Protein Thioesterase in Cotton (Gossypium hirsutum L.): Biochemical and Molecular Characterization of a Major Mechanism for the Regulation of Palmitic Acid Content
… be due in part to the activity of a palmitoyl-acyl carrier protein (ACP) thioesterase (PATE). In embryo extracts, PATE activity was highest at the maximum rate of reserve accumulation (oil and protein). The cotton FatB mRNA transcript abundance also peaked during this developmental stage, …
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Fettsäuretransport in die peroxisomale Matrix von <i>Arabidopsis thaliana</i>
… cerevisiae eine aktivierte Fettsäure in Form von Acyl-CoA postuliert. Andererseits sind für die weitere Metabolisierung durch ß-Oxidation die beiden peroxisomalen Acyl-CoA-Synthetasen LACS6 bzw. LACS7 notwendig. Der Transport der mit CoA aktivierten Fettsäure in die Peroxisomen und die dennoch …
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Isoflurane : interaction with hepatic microsomal enzymes
… of the Δ6-desaturase free of contributions from acyl-CoA synthetase and lysophospholipid acyltransferase, as well as enzyme decay. The kinetics of isoflurane inhibition of the Δ6-desaturase were then superimposed and studied by computer modelling.
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Intestinal cytoplasmic lipid droplets, associated proteins, and the regulation of dietary fat absorption
… including perilipin 3, apolipoprotein A-IV, and acyl-CoA synthetase long-chain family member 5. The identification of the enterocyte CLD proteome provides new insight into potential regulators of CLD metabolism and the process of dietary fat absorption.</p> <p>We also investigated the effect of …
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The Role of Sleep in Memory Consolidation with an Induced Sleep-Like State in Drosophila AND The Role of Alpha-synuclein in Fatty Acid Metabolism
… a role in fatty acid metabolism and specifically acyl CoA synthesis, further studies that examine the interaction of alpha-synuclein with free fatty acids could provide a better understanding of the protein's normal function.</p><p>Method: We examined the interaction of alpha-synuclein with oleic …